Not exact matches
The researchers were able to reverse these
epigenetic changes with the
use of an FDA - approved drug, forcing the cancer cells out of hiding and potentially making them better targets for the same immune
therapy that in the past may have failed.
In the future,
epigenetic editing could also be
used to design novel
therapies by initiating permanent changes to cell biology.
This is both a useful tool for giving us a better understanding of the genetic and
epigenetic program controlling the self - renewal of stem cells, and on a practical side, it could allow us to inexpensively produce large numbers of immune cells, which could then be
used for regenerative medicine or immune
therapy.»
Instead we can
use the
epigenetic clock to monitor their cells» aging rate and to evaluate which
therapies slow the biological aging process,» explained Horvath.
While both studies are bad news for many women, Horvath suggests that scientists in the future may
use the
epigenetic clock as a diagnostic tool to evaluate the effects of
therapies, like hormone
therapy for menopause.
Chaired by Prof. Dirk Schadendorf, talks covered topics which included: melanoma epidemiology in the in period since the start of the German National Skin Cancer screening programme (Dr Andreas Strang); an overview of melanoma
therapies used in stage IV melanoma; adjuvant
therapies and prognosis in stage III melanoma (Dr Lisa Zimmer); tumour heterogeneity, plasticity and resistance in melanoma (Alexander Roesch); epigenomics of normal and abnormal cell differentiation (Bernard Horsthermeke); and, genetics and
epigenetics of uveal melanoma (Michael Zeschnigk).
While many of today's tools were not yet available in 1991, IFM was already focused on
using this emerging knowledge to adapt
therapies to the patient (rather than the reverse) by training clinicians to examine the genetic and
epigenetic factors for each patient and to develop an individualized therapeutic approach that addresses these underlying factors.