A successful candidate should have the following qualifications: a Ph.D. in the field of Molecular Biology, Cell Biology, Biochemistry or related field; an established track - record of publications in peer - reviewed journals; solid experience in the biochemistry of complex DNA - binding proteins (such as chromatin remodeling factors or DNA repair proteins), their purification from heterologous expression systems as well as their characterization
using functional studies such as by isothermal titration calorimetry fluorescence, transcription assays.
Project Title:
Using functional studies to explore potential high penetrance melanoma susceptibility genes identified using whole exome and genome sequencing.
Not exact matches
A
study published in Current Biology
used functional magnetic resonance imaging (fmri) of the brains of three to seven month old infants to assess brain activity in relationship to sound.
In the new
study, the researchers
used functional magnetic resonance imaging (fMRI) to record brain responses in sleeping babies while they were presented with emotionally neutral, positive, or negative human vocalizations or nonvocal environmental sounds.
The
study team conducted a series of behavioral and brain imaging
studies using functional magnetic resonance imaging (fMRI).
Researchers
used functional MRI to
study the recovery of 12 high school football players with concussion and compared them to 12 uninjured teammates.
To date, there have been no
studies looking at
functional recovery following exhaustive running and the
use of compression garments.
This
study used a randomized controlled double - blinded design to determine the
functional recovery effects of wearing below - knee compression socks compared with placebo noncompressive below - knee socks.
A new
study in Biological Psychiatry: Cognitive Neuroscience and Neuroimaging
using magnetic resonance imaging (MRI) reports a link between reduced
functional activation and reduced cortical thickness in the brains of patients with bipolar disorder.
In a new
study, published today in the journal Advanced
Functional Materials, researchers
used a combination of 3D imaging and 3D printing techniques to create a custom silicone guide implanted with biochemical cues to help nerve regeneration.
Focusing on the neural pathway from the brain's prefrontal cortex to the amygdala, they combined optogenetics — a technique that
uses light to control the activity of neurons in living tissue — with behavioral testing, a methodology that allows researchers to
study functional connections between different regions of the brain.
The computational method is also so general that it can be
used to
study all sorts of other proteins bound to various types of
functional molecules,» says Johan Åqvist.
Using data from National Database for Autism Research (NDAR), lead author Kristina Denisova, PhD, Assistant Professor of Psychiatry at CUMC and Fellow at the Sackler Institute,
studied 71 high and low risk infants who underwent two
functional Magnetic Resonance imaging brain scans either at 1 - 2 months or at 9 - 10 months: one during a resting period of sleep and a second while native language was presented to the infants.
In the future,
studies are aimed at
using novel molecular approaches to selectively delete AMPK in specific brain regions associated with nicotine dependence to better understand the
functional role of this protein in addiction.
In a
study under way at USP's Neuroimaging Laboratory (LIM - 21), the researchers are now seeking to correlate the cognitive profile observed in the two groups of cocaine - dependent patients with decision - making and resting - state brain activity,
using functional magnetic resonance imaging (fMRI).
In this new
study and for the first time, scientists
used functional magnetic resonance imaging (fMRI) combined with a standard clinical trial design to derive an unbiased brain - based neurological marker to predict analgesia associated with placebo treatment in patients with chronic knee osteoarthritis pain.
For the present
study, researchers
used functional magnetic resonance imaging (fMRI) to assess brain response to sensory stimulation in 35 women with fibromyalgia and 25 healthy, age - matched controls.
The team's approach relied on methods developed in the past decade or so to
study «
functional connectivity» in the adult human brain — essentially
using fMRI to determine which brain regions have synchronized activity when the subject is not engaged in any particular task.
The result was the largest deletion ever observed in the dystrophin gene
using CRISPR / Cas9, and the
study was the first to create corrected human iPS cells that could directly restore
functional muscle tissue affected by Duchenne.
Dr. Aron and colleagues based their
study's conclusions on a neuroimaging
study using functional magnetic resonance imaging (fMRI) scanning that measures brain activity by detecting changes in blood flow.
Led by neurologist Bradley Schlaggar, the group
studied 238 healthy volunteers, 7 to 30 years old,
using functional MRI, a technique that identifies active neural circuits based on blood flow and blood oxygen levels.
«Our results demonstrate for the first time that human adult skin cells can be
used to efficiently and rapidly generate
functional pancreatic cells that behave similar to human beta cells,» says Matthias Hebrok, PhD, director of the Diabetes Center at UCSF and a co-senior author on the
study.
Earlier, for his Ph.D., he
used his physics training to
study biological interactions at the molecular resolution — but for his postdoc he changed approaches dramatically, turning to cell biology and applying his skills to the development of high - resolution
functional imaging of DNA transcription in living cells.
Johnson, along with
study co-author and post-doctoral researcher Jingyun Ye at the University of Pittsburgh, examined a series of eight different
functional groups of Lewis acid and base pairs (Lewis pairs for short), which are highly reactive compounds often
used as catalysts.
Over three days, Muzik and Diwadkar
studied Hof's brain and body functions
using two distinct imaging techniques — including
functional magnetic resonance imaging (fMRI) to
study his brain and positron emission tomography (PET) to
study his body.
Neuromania: On the Limits of Brain Science (Oxford University Press, 2011) debunks the budding idea that a
study or news report accompanied by a colorful brain image is more reliable than research that does not
use flashy
functional MRI technology.
These comprised not only «conventional» behavioral
studies, but also the physical effects on the brains of test participants by measuring the Blood Oxygen Level - dependent (BOLD) response
using functional Magnetic Resonance Imaging (fMRI) scans.
The fNIRS scans indicated that the concussed brain activated at a lower threshold and drew from a wider area — a sharp contrast from earlier
functional magnetic resonance imaging (fMRI)
studies using concussion patients.
«Our
study sets the stage for further research to identify which additional cues could induce these neurons to fully mature and incorporate into
functional circuits, thereby allowing this approach to potentially be
used in the clinic,» Berninger says.
This is important to the
study of mental illness, says Cole, who made the discovery
using functional magnetic resonance imaging (fMRI), because it is easier to analyze a brain at rest.
CU Boulder researchers
used functional MRI scans (fMRI) to
study brain activity in a group of 37 fibromyalgia patients and 35 control patients as they were exposed to a variety of non-painful visual, auditory and tactile cues as well as painful pressure.
Sinha and her colleagues
used functional magnetic resonance imaging to
study brain activity in people exposed to stimuli ranging from highly stressful — images of mutilated bodies or someone pointing a gun — to neutral, such as a chair, table or lamp.
Different types of cognitive tasks spur activity in various regions of the brain, as indicated by
studies using functional magnetic resonance imaging (fMRI).
In a 2005 Harvard University
functional imaging
study of working memory — that short - term memory we
use to carry on conversations or remember telephone numbers — a group of volunteers were given verbal attention tasks while inside the scanning machine.
Measures of pain,
functional impairment, and
use of health care resources were not different between the
study groups at 7 days or at 3 months after the emergency department visit.
She stayed on as a postdoc in the same microbiology group and now
studies the
functional genomics and bioenergetics of Saccharomyces cerevisiae to improve its
use in winemaking.
In recent years, songbirds» similarities to human vocal learning have piqued researchers» interests in
using them as a
functional animal model to
study the neurological basis for Huntington's disease.
Building on this research in their latest
study, the team analysed liver samples from 2000 patients with Hepatitis C,
using state - of - the art genetic and
functional analysis, to determine the specific IFNL protein responsible for liver fibrosis.
Using functional magnetic resonance imaging (fMRI), an imaging technique that measures brain activity, researchers examined all three groups at the beginning (baseline), middle, and end of the
study while participants performed computer - based speed tasks in the scanner.
Brain scans In the
study, researchers scanned the brains of 39 depressed patients and 37 healthy people
using functional magnetic resonance imaging (fRMI).
The
study was conducted by
using positron emission tomography (PET) and
functional magnetic resonance imaging (fMRI).
However, in the current
study, when the investigators
used mutant bacteria that could not make
functional pili and flagella, the bacteria could still infect the mice.
According to a groundbreaking
study published in this week's online edition of the Proceedings of the National Academy of Sciences, they have chemically synthesized a record - length mirror - image protein and
used this protein to demonstrate that a cellular chaperone, which helps «fold» large or complex proteins into their
functional state, has a previously unappreciated talent — the ability to fold mirror - image proteins.
The
study, published online July 29 in Cerebral Cortex,
used functional magnetic resonance imaging, or fMRI, to examine children's brain activity at rest and during two tasks: solving simple math problems and looking at pictures of different faces.
A number of
studies have
used functional MRI to see what our brain looks like as we recall pleasant memories, watch scary movies or listen to sad music.
Previous
studies have
used functional magnetic resonance imaging (fMRI) scans to show that similar areas of the brain are activated when someone is in pain and when they see another person in pain.
In the first
study to examine the intrinsic
functional connectivity of the brain in relation to social media
use, Dar Meshi and colleagues observed connectivity between regions of the brain previously established to play a role in self - cognition, in 35 participants.
Researchers
using functional MRI (fMRI) have found that neurofeedback training has the potential to reduce the severity of tinnitus or even eliminate it, according to a
study presented today at the annual meeting of the Radiological Society of North America (RSNA).
Next, Yolanda Schaerli, first author of the
study, successfully demonstrated that the four networks are
functional by building them in the bacteria E. coli
using the tools of synthetic biology.
The focus of the
study was to investigate the association of body mass index to survival, health care
use and
functional deficiencies following a severe sepsis hospitalization.