The firm's most ambitious effort to peer inside us will
use iron nanoparticles that attach to specific molecules in the bloodstream linked to cancer or heart disease.
They have been working on
using iron nanoparticles doped with Pd, Ni or Cu to perform catalytic reactions such as Suzuki - Miyaura cross couplings, Sonagashira coupling, and reduction of nitro - containing aromatics.
Not exact matches
This clinical study, published in the Proceedings of the National Academy of Sciences, tested the possibility of imaging inflammation in the pancreas of human volunteers
using ferumoxytol, a coated
iron nanoparticle approved by the FDA as an
iron replacement therapy, and MRI.
Instead of simply applying an antibiotic to the teeth, they took advantage of the pH - sensitive and enzyme - like properties of
iron - containing
nanoparticles to catalyze the activity of hydrogen peroxide, a commonly
used natural antiseptic.
In that study, Gao showed that an
iron oxide
nanoparticle behaved similarly to a peroxidase, an enzyme found naturally that catalyzes oxidative reactions, often
using hydrogen peroxide.
The researchers were able to rapidly generate uniform heat throughout frozen tissues by mixing tiny silica - coated
iron oxide
nanoparticles, each one with a diameter 150 times smaller than a red blood cell, into the cryopreservation solution
used for vitrification.
Previous cancer studies had shown that by injecting tumors with magnetic
nanoparticles made of
iron oxide — «essentially rust, with well - tuned magnetic properties,» Anikeeva says — then exposing them to rapidly alternating magnetic fields, excited
nanoparticles can be
used to heat and destroy cancer tumors while leaving surrounding, healthy tissue intact.
It is simple, easy to
use and the
nanoparticles employed (silica,
iron oxides) can be metabolized by the organism.
For it is reason, the current
iron oxide
nanoparticles are not
used anymore and we started to look for other options.»
Certain strains of bacteria absorb
iron to make magnetic
nanoparticles that let them navigate
using the Earth's magnetic field.
Less often
used are contrast agents made from
iron oxide
nanoparticles, which are considered somewhat safer because the body already contains
iron.
To find tumors via MRI, the Stanford team
used a new contrast agent consisting of
nanoparticles of
iron.
The NTU scientists create micro-sized gas bubbles coated with cancer drug particles and
iron oxide
nanoparticles, and then
use magnets to direct these bubbles to gather around a specific tumour.
The team
used iron oxide for the core of the
nanoparticles, which not only enables the team to
use them for magnetic resonance imaging, but opens up possibilities in remote guidance and localized magnetic heating to hasten the breaking up of the clots.
Using the new data from the research teams on the West Coast, Eisenbach and Kent were able to precisely model the measured atomic structure, including defects, from a unique
iron - platinum (FePt)
nanoparticle and simulate its magnetic properties on the 27 - petaflop Titan supercomputer at the OLCF.
By taking multiple images of the
iron - platinum
nanoparticle with an advanced electron microscope at Lawrence Berkeley National Laboratory and
using powerful reconstruction algorithms developed at UCLA, the researchers determined the precise three - dimensional arrangement of atoms in the
nanoparticle.
The researchers then
used the three - dimensional coordinates of the atoms as inputs into quantum mechanics calculations to determine the magnetic properties of the
iron - platinum
nanoparticle.
The Bulte Lab has developed methods to label cells magnetically
using tiny superparamagnetic
iron oxide
nanoparticles in order to make them visible by magnetic resonance imaging; this technology has now been introduced in the clinic for several cell therapy applications.
A 2017 study co-authored by John Bischof, professor of mechanical engineering at the University of Minnesota, and published in Science Translational Medicine,
used specially coated
iron oxide
nanoparticles.