Sentences with phrase «use of a mouse as»

-- 90 percent of genes associated with disease are identical in the human and the mouse, supporting the use of mice as model organisms.

Apple iPhone users can pair their device with a Bluetooth wireless keyboard, but they won't be able to make use of a mouse as iOS doesn't support them.

Not exact matches

The Surface Pro runs Windows 10, which (unlike Windows 8) is a full - blown desktop - first OS, and as such it works perfectly with peripherals like an external mouse and all of the legacy Windows apps many people use every day.

As Andreessen explains, using this technique means that» [e] ach time you do something, you get to write it down and you get that little rush of endorphins that the mouse gets every time he presses the button in his cage and gets a food pellet.»

A gaming experience my startup created was for PepsiCo and involved using your body as the game controller to provide input on the screen instead of using a traditional mouse or handheld controller.

The headset already can be used to control most ordinary functions in common software, such as word processing and spreadsheet programs, by taking the place of a mouse — the cursor simply follows your gaze, and you can think your way into triggering the equivalent of a left or right mouse click.

Using the gene - editing tool CRISPR - Cas9 to turn off certain genes in a mouse zygote as well as other new techniques to enrich the pluripotent stem cells of a rat, the group managed to grow various rat organs (a pancreas, heart, and eyes) in a mouse embryo.

But, as journalist Steve Connor reports, the reference to editing was intentional: «Scientists have used the genome - editing technology to cure adult laboratory mice of an inherited liver disease by correcting a single «letter» of the genetic alphabet which had been mutated in a vital gene involved in liver metabolism.»

Well, that's more in honour of my grandmother who also used to make «mice» cookies, except she didn't shape hers as neatly as my mother did.

i added a bit of oil olive to the dough and subbed pecans as i didn't have walnuts and used 1/2 bread flour and doubled the recipe as i wanted a super mega size loaf, going to use it for turkey sandwiches along with a tomato soup, can't wait for dinner, I'm so excited to find pom recipes as well, the chocolate dipped shortbread looks like christmas on a plate!Re; your mouse inthe house, we lived thru an infestation, only problem the children thought they were pets at the time!

Hassles such as buying paper towels or searching for the perfect used car that used to require legwork, human interaction, and possibly even wearing pants can now be done with a click of a mouse from one's own living room.

Not only can these Mickey Mouse Stickers make the perfect reward system when used as potty stickers and teamed with one of our FREE Potty Training Charts, but they can also be added to a potty chair to make a decorative statement!

information about your visit, including the full Uniform Resource Locators (URL) clickstream to, through and from the website (including date and time), items you viewed or searched for, page response times, download errors, length of visits to certain pages, page interaction information (such as scrolling, clicks, and mouse - overs) and methods used to browse away from the page.

Using the mouse as an experimental model, LMU neurobiologist PD Dr. Conny Kopp - Scheinpflug and her research group have now demonstrated that the activity of nerve cells in the auditory system has a direct effect on myelinization — higher levels of activity correlate with the formation of thicker myelin sheaths.

For researchers using mouse models to study a variety of cancers, including lymphoma, melanoma, breast, and prostate cancers as well as autoimmune and infectious diseases, the panel facilitates a highly sensitive and high - throughput investigation of biomarkers associated with disease progression.

The ability of SIF - seq to use reporter assays in mouse embryonic stem cells to identify human embryonic stem cell enhancers that are not present in the mouse genome opens the door to intriguing research possibilities as Dickel explains.

The behavioral tests used here modeled one dimension of the disease — an inability to experience pleasure from normal activities — but not others, such as stress and anxiety, and probably tap into different brain mechanisms in mice than in humans, he says.

Burd and her colleagues used a mouse model to study what happens to the brains of those offspring as they age into adulthood to see if the effects persisted.

For this study the researchers targeted very specific types of GABA receptors to improve social behaviors with clonazepam, but the team also found that by using a different drug, they could target other GABA receptors and actually reduce the ability to socially interact in normal mice — underscoring that future medications would need to target very specific receptors so as not to diminish the drug's impacts.

«We know that 70 - 75 percent of glioblastoma patients undergo surgery for tumor debulking, and we have previously shown that MSCs encapsulated in biocompatible gels can be used as therapeutic agents in a mouse model that mimics this debulking,» he continued.

While mouse models have traditionally been used in studying the genetic disorder, Deng said the animal model is inadequate because the human brain is more complicated, and much of that complexity arises from astroglia cells, the star - shaped cells that play an important role in the physical structure of the brain as well as in the transmission of nerve impulses.

Using a powerful microscope to observe mouse oocytes as they split, Ellenberg's group found that the spindles assembled into two coherent structures, one for the future egg and one for the future polar body.At first, spindles appeared throughout the cell in a sort of mesh.

In a series of two papers published online on June 6 in Nature Biotechnology, researchers at the IBS Center for Genome Editing in South Korea showed Cpf1 as a highly specific programmable tool that is suitable for precision genome editing and reported generation of mutant mice using CRISPR - Cpf1.

Using a mouse model of HSV - 1 as well as autopsied samples of human adult and fetal tissues, investigators from Dartmouth College's Geisel School of Medicine found that antibodies against HSV - 1 produced by adult women or female mice could travel to the nervous systems of their yet unborn babies, preventing the development and spread of infection during birth.

She and her colleagues will be exploring the role of YY1 further, using clinical samples as well as mouse models, to look at the protein in diseases like lupus to deepen their understanding of how autoimmunity could result from the «escape» of immune genes from X chromosome inactivation.

They injected the particles directly into mice with an experimental human brain cancer, and into the brains of healthy mice for use as comparison.

They used a somewhat bizarre technique in which two mice were sutured together in such as way that they shared a circulatory system (known as parabiosis), and found old mice joined to their youthful counterparts showed changes in gene activity in a brain region called the hippocampus as well as increased neural connections and enhanced «synaptic plasticity» — a mechanism believed to underlie learning and memory in which the strength of neural connections change in response to experience.

«Using a mouse model of tuberculosis, we have shown lower doses of bedaquiline together with verapamil have the same antibacterial effect as the higher toxic doses,» says Shashank Gupta, Ph.D., a research fellow at Johns Hopkins.

Using a device such as a spaceball — a sort of three - dimensional mouse — the operator marks the positions of the key features in the pictures, such as edges and corners of individual stones.

«Now that we know the mice can be vulnerable to Zika infection, we can use the animals to test vaccines and therapeutics — and some of those studies are already underway — as well as to understand the pathogenesis of the virus,» said senior author Michael Diamond, MD, PhD, a professor of medicine at Washington University.

As researchers develop drugs that target the DUX4 protein, the hope is that these mice will be used to determine whether such drugs can reach skeletal muscle and allow muscle damage to be repaired, even in the presence of DUX4.

«Using models such as zebrafish and neonatal mice that regenerate their hearts naturally, we can begin to identify important molecules that enhance heart repair,» said Ellen Lien, PhD, of The Saban Research Institute of Children's Hospital Los Angeles.

Visibly fluorescent proteins (FPs) from jellyfish and corals have revolutionized many areas of molecular and cell biology, but the use of FPs in intact animals, such as mice, has been handicapped by poor penetration of excitation light.

The scientists of the Farncombe Family Digestive Health Research Institute at McMaster University discovered that mice that harboured in their gut the opportunistic bacteria Pseudomonas aeruginosa (Psa) isolated from celiac patients, metabolized gluten differently than mice treated with Lactobacillus, often used as probiotics.

With chronically infected mice as their model, the researchers used a new technology called ATAC - seq to map the regulatory regions of the genome — the sections of DNA involved in switching genes on and off — in the animals» exhausted and functional CD8 + T cells.

We identified c - Jun amino - terminal kinase 3 (JNK3) as a binding partner of β - arrestin 2 using a yeast two - hybrid screen and by coimmunoprecipitation from mouse brain extracts or cotransfected COS - 7 cells.

Using a mouse model, the team identified a specific cell called a subepithelial myofibroblast as an essential source of both Wnts and RSPO3.

In this study, using a mouse transgenic approach, the scientists demonstrated that ILC2s express a checkpoint molecule, known as «PD - L1», that functions to control the expansion of allergy - inducing Th2 cells and the development of allergic pulmonary and gut tissue inflammation.

They have since learned that as many as 40 of those lines may never be fully developed; some may even have been contaminated by mouse cells used to sustain them in the lab.

By using pharmacological small molecule inhibitors as well as neutrophils from genetically modified mouse strains the team could identify essential receptor and signaling pathways involved in the nicotine - mediated activation of neutrophils.

The researchers tested two anti-CK2 drugs for their ability to stimulate the production of new brown fat in mice: a new small - molecule CK2 - blocker called silmitasertib (CX - 4945), which is already in clinical trials as a cancer therapeutic; and a more precise next - generation antisense oligonucleotide (ASO) drug developed in collaboration with Isis Pharmaceuticals, which eliminates CK2 by blocking the RNA instructions cells use to produce it.

Scientists from the University of Lincoln, UK, have now successfully created a simplified, synthesised form of teixobactin which has been used to treat a bacterial infection in mice, demonstrating the first proof that such simplified versions of its real form could be used to treat real bacterial infection as the basis of a new drug.

As proof - of - principle of the potential efficacy, Zhang's team grew human ovarian tumors in immunocompromised mice, then injected short - interfering RNAs to block the tumors» growth using RNA interference against FAL1.

In addition to fruit flies, they successfully used the program to analyze images of zebrafish and mice, as well as data collected from a commercial light sheet microscope and a commercial confocal microscope.

Mice were placed in a two - room arena, and the mental representation of one of these rooms was selectively labeled using the same technique as above — that is, restricting doxycycline when present in one of the rooms, but not the other.

In spite of this sizable gap, certain vitally important processes such as memory formation use similar cellular mechanisms in humans, mice and flies, as the researchers» experiments were able to prove.

For prevention studies, they injected mouse α - syn synthetic preformed fibrils into wild - type, normal mice, as a control, and then immediately treated the mice with Syn303, one of the MAbs used (or IgG, another type of common antibody, for the control mice).

A team of developmental biologists led by Hans Schöler and Karen Hübner at the University of Pennsylvania placed densely packed clusters of stem cells from mouse embryos in a petri dish, using fetal calf serum as a growth medium and adding a gene protein that turns green when germ cells form.

He has worked in the biotech industry as a research scientist for over 11 years with a focus on emerging technologies including gene targeting in mice, molecular analysis of transgenes using GFP variants at the single cell level, and developing flow cytometry reagent kits to speed up assay development time for researchers.

After chronicling the different shifts of decomposers on the mice, and seeing the same shifts operating on the humans, the researchers built a computer model using the mouse data to see whether the microbial composition could be used to predict times of death, using the humans as a test case.