Sentences with phrase «use of adjuvant»

Phase III Randomized, Placebo - Controlled Clinical Trial Evaluating the Use of Adjuvant Endocrine Therapy + / - One Year of Everolimus in Patients with High - Risk, Hormone Receptor - Positive and HER2 / neu Negative Breast Cancer.

The authors demonstrated the clinical utility of the Prosigna assay to aid decision - making in relation to the use of adjuvant chemotherapy for both node - negative and node - positive disease.

A key to the formula lies in the use of an adjuvant — which boosts the potency of the vaccine — called CpG.

Today UNIL - VFL provides access to adjuvants, adjuvant quality control technology, adjuvant formulation expertise, technology transfer, training, and bespoke adjuvant R&D services, allowing partners to gain optimal benefit from the use of adjuvants and vaccine formulation technology.

The rational use of adjuvants will be studied in detail, as very often researchers use a «shotgun» approach with adjuvants, testing entire panels with their antigens in the search for improved immune responses.

It appears to be desirable to avoid the use of adjuvanted vaccines in cats.

Avoid the use of adjuvanted (inactivated) vaccines whenever feasible.

It appears desirable to avoid the use of adjuvanted vaccines in cats.

Not exact matches

On examination, the ozone proved to be largely interacting with one of the primary components of skin oils, the natural organic compound known as squalene, which is used as an adjuvant and moisturizer.

In addition to a comprehensive study of their use in vaccines, this article summarizes the benefits and challenges associated with the use of these polymer systems as adjuvants.

These studies will investigate whether Src kinase inhibitors are best used in the adjuvant setting post-surgery or after chemotherapy to prevent the formation of local and distant disease recurrence.

Commenting on the results, Dr Olivier Michielin, head of Personalised Analytical Oncology, CHUV, Lausanne, Switzerland, said: «This was the first attempt to use checkpoint blockade in the adjuvant setting of melanoma.

But if you're using adjuvant to supply vaccine to the rest of the world, that's a different risk / benefit equation altogether.

A key factor is how many companies will use so - called adjuvants, which boost the immune response and thus lower the amount of antigen needed per shot.

The US is now funding a large study of countries that used adjuvanted vaccines in 2009 to see if they may have caused narcolepsy.

However, scientists believe for practical use, these potential vaccines would require multiple doses or the addition of adjuvants, which enhance the immune response.

Progress in prevention and early detection, and the use of chemotherapy after surgery (adjuvant chemotherapy), have achieved significantly increase survival in this disease in the last ten years, but much remains to be done.

The Use of Antimicrobials as Adjuvant Therapy for the Treatment of Obesity and Insulin Resistance: Effects and Associated Mechanisms — Sandra Aparecida dos Reis — Diabetes / Metabolism Research and Reviews

Adjuvants are increasingly used by the vaccine community and are essential components of modern vaccines, particularly for their ability to enhance and bias immune responses and for their dose - sparing properties.

This will include testing the mechanism of action of different adjuvant and antigen formulations by measuring B - and T - cell responses and by using various functional assays (ELISA, FACS, cytokine profiles), transcriptomics and / or proteomics.

This can be achieved either by a combination of PAMPs working in synergy to activate DCs or through the use of novel adjuvants.

FDA approves trastuzumab (Herceptin) for use with other drugs in the adjuvant treatment of women with early - stage node - positive HER2 - overexpressing breast cancer.

The HZI will develop a vaccination protocol for mucosal administration based on three novel strategies: (i) development and optimization of a vaccination protocol in which parenterally - primed T and B cells are subsequently pulled into the mucosa by the local delivery of the cognate antigen to the requested effector site, (ii) testing the co-administration of antigens with novel mucosal adjuvants using different mucosal immunisation routes and schedules, and (iii) testing various nanoparticles co-administered with different immunomodulators for their ability to generate both systemic and mucosal immune responses following transcutaneous / trans - follicular vaccination.

The CD8 + T - cell responses will be benchmarked against those obtained using the adjuvant QS - 21, a known immunomodulator of CD8 + T - cell responses.

We need a new type of vaccine that uses select components of a microbe or tumor cell or other cause of disease, and administers these with other defined substances, such as adjuvants, that directly exploit immunology.»

Comparative effects of adjuvants (IRTA, SSI, HZI): The TIV influenza vaccine will be used to compare adjuvants in different species (mice, ferrets and pigs).

SEATTLE, Feb. 05, 2018 (GLOBE NEWSWIRE)-- NanoString Technologies, Inc. (NASDAQ: NSTG), a provider of life science tools for translational research and molecular diagnostic products, today announced the publication of a landmark study in which Danish researchers used the Prosigna ® Breast Cancer Assay risk of recurrence (ROR) score to accurately predict rates of 10 - year distant recurrence (DR) of cancer in a comprehensive and population - based cohort including all postmenopausal women in Denmark with early - stage hormone receptor (HR)- positive, Her - 2 negative breast cancer who received 5 years of adjuvant endocrine therapy according to nationwide guidelines between 2000 and 2003.

They seek to improve and prolong the level of protection seen in RV144 by using an extra vaccine boost and different adjuvants that may increase and prolong antibody responses.

«In an era of increasing use of minimally invasive surgery that enables administration of adjuvant therapy more reliably,» says Dr. Yendamuri, «the paradigm of routine neoadjuvant therapy for patients with this stage of disease should be reconsidered.»

«The question now is, can the nanoparticles be effective delivery vehicles for vaccines or be used for for co-delivery of antigens and adjuvants?

Chaired by Prof. Dirk Schadendorf, talks covered topics which included: melanoma epidemiology in the in period since the start of the German National Skin Cancer screening programme (Dr Andreas Strang); an overview of melanoma therapies used in stage IV melanoma; adjuvant therapies and prognosis in stage III melanoma (Dr Lisa Zimmer); tumour heterogeneity, plasticity and resistance in melanoma (Alexander Roesch); epigenomics of normal and abnormal cell differentiation (Bernard Horsthermeke); and, genetics and epigenetics of uveal melanoma (Michael Zeschnigk).

Gerbin and co-researchers at the Institute of cell biology in Switzerland found creatine could be used successfully as an adjuvant therapy for bone fracture healing or for the treatment of osteoporosis 7.

The scientists concluded that «this study shows that fenugreek seeds can be used as an adjuvant in the control of type 2 diabetes mellitus in the form of soaked in hot water».

Recently, fibrosarcomas have been removed from areas of the body typically used for vaccination and, to the surprise of the veterinary profession, particles of aluminum based vaccine ingredients (called «adjuvants») were discovered within the tumor.

We use Merial feline vaccines exclusively to vaccinate our cats, due to the fact that Merial is the only manufacturer that has absolutely NO adjuvant in any of their cat vaccines.

It may be that debris are carried under the skin when a large needle is used to administer these vaccines, it may be that components (adjuvants) in the vaccines are the source of the problem - we just do not know yet.

Because of this, the only FVRCP vaccine for cats used at Windmill Animal Hospital is the adjuvant - free vaccine, PureVax.

Vaccine Selection Challenges Recommendations to avoid use of inactivated (adjuvanted) vaccines in cats have been met with resistance from the industry.

Although killed or inactivated products make up about 15 % of the veterinary biologicals used, they have been associated with 85 % of the post-vaccination reactions, mainly because of the acute adverse responses induced by the adjuvants used in companion animal, wildlife and livestock species (Dodds, 1997; Luján et al, 2013).

Along with utilizing the mistaken location, an adjuvanted rabies vaccine was used as a substitute of PureVax and Hen paid a excessive value for these careless choices.

In addition to using the wrong location, an adjuvanted rabies vaccine was used instead of PureVax and Chicken paid a high price for these careless decisions.

Not all vaccines have adjuvants in them, and by choosing to use non-adjuvanted vaccines, the risk of vaccine - associated sarcomas is greatly reduced.

There is a definite association between vaccine - associated sarcomas and the use of vaccines with adjuvants in them.

It is not, in my view, necessary in the case of the discovery of a new use for an old compound that the combination of the compound with the adjuvant be itself novel in any sense other than that it is required in order to give effect to this particular use of the compound.

It is the idea of applying the old compounds to the new use as plant growth regulators; the character of the adjuvants follows inevitably once their usefulness for that purpose has been discovered.

Scharton - Kersten, T., Glenn, G. M., Vassell, R., Yu, J., Walwender, D., Alving, Carl R. Principles of transcutaneous immunization using cholera toxin as an adjuvant.

There has been a substantial increase in the use of temporary androgen suppression therapy (AST) as an adjuvant management of prostate cancer.