Sentences with phrase «use of bone marrow»
The use of bone marrow increased from 20 percent in countries with low and low - middle incomes to 50 percent with high - middle incomes to 64 percent with high incomes.
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«Despite current drugs and use of bone marrow transplantation, multiple myeloma is still incurable, and almost all patients eventually relapse,» says co-principal investigator and multiple myeloma specialist Craig Hofmeister, MD, MPH, assistant professor of medicine and a member of the OSUCCC — James Translational Therapeutics Program.
The use of bone marrow - derived stem cells is well established in the treatment of human cancer patients, and veterinary applications for bone marrow - and adipose - derived stem cells are being evaluated.
Not exact matches
A new study explains how a widely used drug is effective against inflammatory bowel disease and rejection of bone marrow transplants, while suggesting another way to address both health issues.
Richard Jones, M.D., professor and director of the Bone Marrow Transplant Program at Johns Hopkins, developed a now commonly used assay to study ALDH levels in individual cells.
In the early 2000s, Johns Hopkins scientists Leo Luznik and Ephraim Fuchs found that giving patients high doses of cyclophosphamide — a drug derived from nitrogen mustard and used to treat blood cancers — three days after bone marrow transplant successfully thwarts acute and chronic GVHD.
Medical centers around the world now use the Johns Hopkins protocol of post-transplant cyclophosphamide, and Luznik says the inexpensive drug is becoming increasingly mainstream in bone marrow transplant regimens.
It is similar to how radiation and chemotherapy are used to «condition» patients for a bone marrow transplant, to improve engraftment of transplanted immune cells.
Dr. Zubair, medical and scientific director of the Cell Therapy Laboratory at Mayo Clinic in Florida, says the experiment will be the first one Mayo Clinic has conducted in space and the first to use these human stem cells, which are found in bone marrow.
The scientists began to use post-transplant cyclophosphamide in clinical trials of fully matched bone marrow transplants in 2004.
«We believe that small subsets of metastatic tumor cells have the ability to adopt the mechanisms used by immune cells to exit the blood vessels into the lungs, the bone marrow, the brain, and other organs.
«New approach could make bone marrow transplants safer: Using antibodies in place of radiation, chemotherapy.»
(Mackenzie notes that it shouldn't be a problem for her strategy, because she plans to use the same kind of cells as bone marrow transplants, which haven't caused tumors.)
Preclinical and clinical tests have been used successfully in the past for the introduction of therapies for bone marrow transplantation and the regeneration of skin and cornea in patients.
«No reliable approach is currently available for complete restoration of damaged articular cartilage,» said Dr. Bai - wen Qi, «in this study, CS / PVA gel was combined with rabbit bone marrow stromal cells (BMSCs) transfected with hTGFβ - 1 and used to repair rabbit articular cartilage defects and the repair effect was evaluated.»
She is one of 16 patients in the first U.S. trial using cells extracted from adult bone marrow to reverse advanced heart failure.
Instead of using white blood cells, the British researchers, working with a Dutch group, want to take stem cells from bone marrow and insert the ADA gene into these.
The researchers used a new cell tracing method to follow the movement of peritubular macrophages from the bone marrow to the testes.
Using an approach developed at Maisonneuve - Rosemont, consisting of an autograft to reduce tumour mass followed by a family allograft three to four months later to clean the bone marrow of myeloma cells with immune cells from a family donor (immunotherapy), the study resulted in a total cure rate of 41 %, a record level using this straUsing an approach developed at Maisonneuve - Rosemont, consisting of an autograft to reduce tumour mass followed by a family allograft three to four months later to clean the bone marrow of myeloma cells with immune cells from a family donor (immunotherapy), the study resulted in a total cure rate of 41 %, a record level using this strausing this strategy.
• A Columbia University team headed by Silviu Itescu used human bone marrow to build new blood vessels in the hearts of rats.
The stem cells used to treat Paizley, specific to the blood, came from the bone marrow of a healthy adult donor.
The latest study builds off of work Kawai and his colleagues began fourteen years ago, when they launched the first clinical trial that attempted to use bone marrow to induce immune tolerance for kidney recipients, to avoid the sometimes dangerous side effects of life - long immosuppressive therapy.
«At this time of relapse, we would take a bone marrow biopsy from a patient, and we would test each therapy individually or in combinations that are typically used in the clinic.
Beyond organ transplants, many experts think that the protocol could be used to treat other diseases that require bone marrow transplants but for which there are severe shortages of matched donors.
Earlier this year, Lerner, Xie and their colleagues reported using the new method to find an antibody that can perform the remarkable trick of turning bone marrow cells into young brain cells, via a previously unknown signaling mechanism.
These so - called hematopoietic stem cells (from Greek meaning «to make blood») have been reliably used over the past 40 years to seed bone marrow transplants in the treatment of some cancers and immune disorders.
«Our group pioneered the development of cell culture technology for harvesting large numbers of stem cells from human bone marrow and human umbilical cord blood,» Dr. Yeh said, noting that stem cells from these two sources are abundant and can be guided into different types of cells using tissue engineering.
Doctors generally treat aplastic anemia effectively using immunosuppressives — drugs that prevent the immune system from attacking bone marrow — allowing recovery of the patient's own marrow and long - term survival.
Doctors also used chemicals and radiation to obliterate his bone marrow, the source of all his blood cells — a crude but effective strategy to destroy any cancerous ones that survived chemotherapy.
Among their breakthroughs was a medical model for regenerating bladders using stem cells harvested from a donor's own bone marrow, reported in the Proceedings of the National Academy of Sciences in 2013.
However, a new study published in Cell Reports provides clues about how the dose of transplanted bone marrow might affect patients undergoing this risky procedure, frequently used to treat cancer and blood diseases.
They then used human stem cells derived from bone marrow that would normally become bone cells to test the effects of the nanoparticles on stem cell proliferation and differentiation.
Subsequent tests revealed that the retrovirus used to ferry the corrective gene into the DNA of blood - making cells in the bone marrow had lodged in or near a gene that regulates T cells, possibly prompting their uncontrolled growth.
Now, the Laboratory of Malaria Immunology Team at the Immunology Frontier Research Center (IFReC), Osaka University, headed by Professor Cevayir COBAN, have used mouse malaria models to show that robust immune activation and invasion of parasite by - products into the bone marrow during and after malaria infection leads to an adverse balance in bone homeostasis - a process usually tightly controlled - by bone forming osteoblasts and bone resorbing osteoclasts.
Researchers have been experimenting with several types of muscle and bone marrow stem cells, which are easier to obtain and sidestep the ethical debate over using HES cells.
More than 40 clinical trials are underway using other kinds of stem cells, mainly bone marrow cells from the patients themselves.
Understanding and reproducing key features of bone marrow formation — and hence, the creation of blood cells and platelets in tissue culture for storage and later use — could help in treatment of a variety of medical problems.
«Source of stem cells used for bone marrow failure treatment varies worldwide.»
Each step of the tissue engineered silk bone marrow development furthered the amount of successful platelet production and allowed the researchers to use a minimal amount of resources while maximizing the output of functional platelets.
«Transplantation allows clinicians to treat the cancer most effectively by using more intense doses of chemotherapy than can typically be given, while avoiding fears of wiping out the bone marrow.
Importantly, researchers found that the drugs are only effective when administered directly into a vein (intravenous), rather than the more commonly used technique of administering the drugs directly into bone marrow (intraosseous).
Andrew Steele, Cheng Cheng Zhang and colleagues used radiation to deplete the bone marrow of mice genetically engineered to not produce the prion proteins.
Clough BH, Zeitouni S, Krause U, et al., Rapid Osteogenic Enhancement of Stem Cells in Human Bone Marrow Using a Glycogen ‐ Synthease ‐ Kinase ‐ 3 ‐ Beta Inhibitor Improves Osteogenic Efficacy In Vitro and In Vivo.
This gene is identified by an investigational FLT3 Mutation Assay companion diagnostic a specific lab test of their blood or bone marrow, which is used to see if they have a mutation of the FLT3 gene.
Children with certain variants of a gene called TMPT, for example, can't break down some of the drugs used for leukemia, which end up poisoning their bone marrow.
The independent factors used to predict progression free survival include levels of beta2 - microglobulin, longest diameter of the largest lymph node involved, bone marrow involvement, and hemoglobin levels.
The Bone Marrow and Stem Cell Transplant Program is expanding the use of this technique for patients with solid tumors including neuroblastoma and brain tumors; a variety of high - risk hematologic diseases, such as thalassemia major and transfusion - dependent sickle cell disease; and other nonmalignant diseases.
A number of adult stem cell therapies already exist, particularly bone marrow transplants that are used to treat leukemia.
The authors also highlight a recent report on the production of platelet from mouse fetal - liver culture - derived MKs using a biomimetic microfluidic platelet bioreactor [5], which may allow the further enhancement of MK production from hiPSCs by the recapitulation of the bone marrow and blood vessel microenvironments.
«The traditional view was that hominins started knapping to make sharp - edged flakes so they could cut meat off of animal carcasses, and maybe used the cores, called «choppers», to break open bones to get at the marrow» Lewis says.