Sentences with phrase «use of mouse models»

The findings of a study published last month shed light on the reasons autism may be more prevalent in men than in women, and prompted the experts» calls for more frequent use of mouse models.

The mouse phenogenomics and the good practices regarding the use of mouse models for scientific research

PHENOMIN offers an international and first class 4 - day session training to provide engineers (Master's degrees), PhDs and researchers with a wealth of information about the good practices regarding the use of mouse models in biomedical research.

OMC is a scientific and technological platform aimed at supporting R&D activities related to the validation and use of mouse models of human disease.

Good practices: use of mouse models for biomedical and scientific research Would you like to learn how to choose, create and analyze your best mouse model?

It provides a wealth of information on good practices in the use of mouse model (standardized techniques, ethics, regulations, analysis, data and resources...) to support attendees in their research.

The school will provide a wealth of information on good practices in the use of mouse model (experimental design, ethics, regulations, analysis, data and resources...) to support attendees in their research.

This unique international event will provide the attendees with an innovative program focused on the best practices in the use of the mouse model for biomedical and basic research; this program also addresses the item of continuing professional education consistent with the new European directive requirement for lab animal protection in experiments.

Not exact matches

Currently SQZ is developing its technology further using mouse models and human blood experiments to understand its mechanisms of action more fully.

Using a «gnotobiotic mouse model» — where mice were «colonized with a synthetic human gut microbiota composed of fully sequenced commensal bacteria» — Desai et al reported on the effects of different diets with different fibre content.

The resulting inoculation looks promising in both ferrets and mice, the most commonly used models of influenza infection.

In the new work, published June 10 in the journal Scientific Reports, Zhao, Reid and colleagues used a highly sensitive probe to measure electrical fields in the corneas of isolated eyes from three different lab mouse models with different types of diabetes: genetic, drug - induced and in mice fed a high - fat diet.

Jeffrey Noebels and his team at Baylor College of Medicine in Houston, Texas used two genetic mouse models of absence epilepsy and compared them to unaffected mice.

The researchers collected samples of indoor dust from 11 homes in North Carolina and tested extracts from the samples in a mouse pre-adipocyte cell model, 3T3 - L1 cells, often used to test compounds for potential effects on the accumulation of triglycerides, a type of fat.

Using the mouse as an experimental model, LMU neurobiologist PD Dr. Conny Kopp - Scheinpflug and her research group have now demonstrated that the activity of nerve cells in the auditory system has a direct effect on myelinization — higher levels of activity correlate with the formation of thicker myelin sheaths.

For researchers using mouse models to study a variety of cancers, including lymphoma, melanoma, breast, and prostate cancers as well as autoimmune and infectious diseases, the panel facilitates a highly sensitive and high - throughput investigation of biomarkers associated with disease progression.

Using a mouse model that expresses an altered form of the normal human prion protein, researchers at University of California, San Diego School of Medicine have determined why the human proteins aren't corrupted when exposed to the elk prions.

These findings allowed researchers to create a chimera virus: a mouse virus with a human viral gene that can be used to test molecules that inhibit human LANA protein in an animal model of disease, treating not only human herpes virus infection but also its associated cancers.

Using a flexible mouse model, her team set out to determine whether anything could be done to restore memory «after a significant number of neurons are lost in the brain.»

The behavioral tests used here modeled one dimension of the disease — an inability to experience pleasure from normal activities — but not others, such as stress and anxiety, and probably tap into different brain mechanisms in mice than in humans, he says.

Burd and her colleagues used a mouse model to study what happens to the brains of those offspring as they age into adulthood to see if the effects persisted.

Researchers have used CRISPR to treat an adult mouse model of Duchenne muscular dystrophy.

That, he says, suggests that the widely used mouse model of cystic fibrosis «might not be appropriate.»

The study results were found using mouse embryonic stem cells, which are good cell models for the study of processes seen in human stem cells.

The positive effect of sialic acid Neu5Gc on the respiratory system was confirmed using a mouse - model: The Neu5Gc molecules consumed with food improved the pulmonary function of the mice, therefore reducing asthma symptoms.

Dr Luis Pedro Coelho, commented: «These findings suggest that dogs could be a better model for nutrition studies than pigs or mice and we could potentially use data from dogs to study the impact of diet on gut microbiota in humans, and humans could be a good model to study the nutrition of dogs.

This is a highly limiting factor for research, because it complicates the annotation of data obtained by molecular techniques, and because it has been shown that gut microbiomes are to some extent specific to their host, and researchers have been using strains of other origin in mouse models.

Researchers then tested cell cultures and mouse models by using a gene editing process called CRISPR - Cas9 to demonstrate how the presence or absence of myomaker and myomerger — both individually and in unison — affect cell fusion and muscle formation.

In this new study published in Nature, Alexandra Van Keymeulen and colleagues used state of the art genetic mouse models to identify the cellular origin of PIK3CA and p53 induced breast tumors.

Dr. Erez and her team used mouse models to study and follow the spontaneous metastasis of melanoma in the brain.

«We know that 70 - 75 percent of glioblastoma patients undergo surgery for tumor debulking, and we have previously shown that MSCs encapsulated in biocompatible gels can be used as therapeutic agents in a mouse model that mimics this debulking,» he continued.

This is an image of neurons in the somatosensory cortex of mouse models of epilepsy used in the study.

Again, using mouse models of glioblastoma — this time created from brain tumor cells that were resistant to the herpes virus — the therapy led to increased animal survival.

For this study, Guttridge, first author David J. Wang, who developed many of the study's concepts, and their colleagues monitored NF - kB activity during tumor development using mouse embryonic fibroblasts and two mouse models.

«The mouse is one of the most utilised models for studying human biology and we use it for creating models of human illnesses and testing new drugs and therapies.

The scientists tested the new compound using a mouse model of TB and found that substituting R207910 for one of three antibiotics in a treatment cocktail significantly reduced the time required to clear the animals» lungs of bacteria.

When the team used the retinoid fenretinide along with anti-estrogen therapy in mouse models of breast cancer, they did not see the expansion of CK5 + cells previously seen with anti-estrogen therapy alone.

The UT Southwestern group had previously used CRISPR - Cas9, the original gene - editing system, to correct the Duchenne defect in a mouse model of the disease and in human cells.

The researchers then used a combination of existing United States Food and Drug Administration - approved drugs to target autophagy and found ovarian cancer cells to be highly sensitive to these drugs in several different mouse cancer models — even among cells resistant to standard chemotherapy.

In this study, the Hiroshima University researchers developed an animal model using severely immunodeficient mice whose livers were partially populated with human cells, in order to reconstruct elements of the human immune system.

The researchers used two different mouse models of diabetes to study the effects of the diet.

In a series of experiments using mouse and rat models of depression reported today in Nature, Hu and her colleagues found that ketamine did affect the lateral habenula — but it was the pattern of firing, rather than the overall amount of activity, that proved crucial.

While mouse models have traditionally been used in studying the genetic disorder, Deng said the animal model is inadequate because the human brain is more complicated, and much of that complexity arises from astroglia cells, the star - shaped cells that play an important role in the physical structure of the brain as well as in the transmission of nerve impulses.

In the current work, they used a new variation of the gene - editing system to repair the defect in both a mouse model and in human cells.

The new study, using an experimental mouse model of diabetes, is published online in the journal PLOS One.

Geha led an investigation using two separate mouse models of eczema, each recreating a separate pathway leading to allergic skin inflammation.

Using a mouse model, the team also demonstrated that two processes during neurodevelopment are regulated by the gene: proliferation — the replication of neuronal stem cells that have the potential to become multiple different kinds of cells, including neurons — and migration — the movement of neurons to specific locations in the brain during development.

Researchers at The University of Texas MD Anderson Cancer Center developed a novel chimeric mouse model to test the combination therapy using immune checkpoint blockades with therapies targeting myeloid - derived suppressor cells (MDSCs).

In their study, Stephanie Cherqui, PhD, associate professor in the UC San Diego School of Medicine Department of Pediatrics, and colleagues used a transgenic mouse model that expresses two mutant human FXN transgenes, and exhibits the resulting progressive neurological degeneration and muscle weakness.

«The next steps are to fully define the role of the interferon response in the development of Down syndrome using mouse models.