Sentences with phrase «use of these drugs result»

Some Viekira Pak and Technivie patients say that their use of the drug resulted in the need for a liver transplant, and some died.

Not exact matches

These risks and uncertainties include, among others: the unfavorable outcome of litigation, including so - called «Paragraph IV» litigation and other patent litigation, related to any of our products or products using our proprietary technologies, which may lead to competition from generic drug manufacturers; data from clinical trials may be interpreted by the FDA in different ways than we interpret it; the FDA may not agree with our regulatory approval strategies or components of our filings for our products, including our clinical trial designs, conduct and methodologies and, for ALKS 5461, evidence of efficacy and adequacy of bridging to buprenorphine; clinical development activities may not be completed on time or at all; the results of our clinical development activities may not be positive, or predictive of real - world results or of results in subsequent clinical trials; regulatory submissions may not occur or be submitted in a timely manner; the company and its licensees may not be able to continue to successfully commercialize their products; there may be a reduction in payment rate or reimbursement for the company's products or an increase in the company's financial obligations to governmental payers; the FDA or regulatory authorities outside the U.S. may make adverse decisions regarding the company's products; the company's products may prove difficult to manufacture, be precluded from commercialization by the proprietary rights of third parties, or have unintended side effects, adverse reactions or incidents of misuse; and those risks and uncertainties described under the heading «Risk Factors» in the company's most recent Annual Report on Form 10 - K and in subsequent filings made by the company with the U.S. Securities and Exchange Commission («SEC»), which are available on the SEC's website at www.sec.gov.

Resistance is also fueled by the massive and often inappropriate use of antibiotics in agriculture; for decades these precious drugs have been used to promote growth and fend off costly infections that can result from the cramped conditions of industrial - scale food animal production.

She said that employers» increased use of high - deductible plans, one of the side - effects of the law, has resulted in patients paying more out of pocket for the drug, and that's «where you're seeing a lot of noise around EpiPen.»

They challenged routine procedures such as the episiotomy, the use of pain - killing drugs, and the use of forceps, which sometimes resulted in damage to the newborn.

The Bible teaches us that Jesus not does not want Wall Street investors getting rich through the suffering of others (a / k / a drug company stocks)-- how many people suffer physically or even die from drugs that should have never been approved for use — but instead are dispensed — to the joy of investors — only to have patients suffer as a result.

Potential subjects were accepted into the study if they had none of the following conditions: severe or symptomatic cardiac disease or hypertension; history of bleeding disorders; chronic history of gastric, intestinal, liver, pancreatic, or renal disease; any portion of the stomach or the intestine removed (other than an appendectomy); history of intestinal obstruction, malabsorption, or use of antacid drugs; cancer (active or use of medications for a history of cancer treatment within the past 5 y); history of chronic alcoholism; a convulsive disorder; or abnormal results in screening blood or urine samples.

Golding says his research on anabolic steroids indicates that they have no effect at all on building lean muscle mass and explains the continued use of the drug as a result of peer - group pressure.

On May 4, Dennis wrote to TAC Executive Director Ollan Cassell: «It seems to me that our concern with results... and our reluctance to carry out the testing because of what we may find is an open admission that this [illegal drug use] is occurring and indeed that we are condoning same.»

Breastfeeding after chemotherapy has been completed may be possible, either by relactation or as a result of another pregnancy, depending upon the drugs that were used.

Another current article describes the illegal use of drugs such as hydrocodone, fentanyl, duragesic, and morphine (opiods); taken in combination by a breastfeeding mother, resulting in her infant's death.

Using drugs or overeating or engaging in risky behavior leads to consequences as a direct result of this behavior.

They have a vested interest in publishing studies that promote the use of their medications and failing to publish study results that call the efficacy or safety of their drugs into question.

The results held true even when researchers accounted for potentially confounding factors such as the presence of aggression within the family and parental stress, depression and drug or alcohol use.

These include the infant with galactosemia, 53,54 the infant whose mother uses illegal drugs, 55 the infant whose mother has untreated active tuberculosis, and the infant in the United States whose mother has been infected with the human immunodeficiency virus.56, 57 In countries with populations at increased risk for other infectious diseases and nutritional deficiencies resulting in infant death, the mortality risks associated with not breastfeeding may outweigh the possible risks of acquiring human immunodeficiency virus infection.58 Although most prescribed and over-the-counter medications are safe for the breastfed infant, there are a few medications that mothers may need to take that may make it necessary to interrupt breastfeeding temporarily.

The side effects of the drug being used constantly results in the need for a C - section.

Physical punishment is associated with a range of mental health problems in children, youth and adults, including depression, unhappiness, anxiety, feelings of hopelessness, use of drugs and alcohol, and general psychological maladjustment.26 — 29 These relationships may be mediated by disruptions in parent — child attachment resulting from pain inflicted by a caregiver, 30,31 by increased levels of cortisol32 or by chemical disruption of the brain's mechanism for regulating stress.33 Researchers are also finding that physical punishment is linked to slower cognitive development and adversely affects academic achievement.34 These findings come from large longitudinal studies that control for a wide range of potential confounders.35 Intriguing results are now emerging from neuroimaging studies, which suggest that physical punishment may reduce the volume of the brain's grey matter in areas associated with performance on the Wechsler Adult Intelligence Scale, third edition (WAIS - III).36 In addition, physical punishment can cause alterations in the dopaminergic regions associated with vulnerability to the abuse of drugs and alcohol.37

Lifetime comorbidity of DSM - IV mood and anxiety disorders and specific drug use disorders: results from the National Epidemiologic Survey on Alcohol and Related Conditions

Subsequently, by virtue of defining that an adult and infant are unable to safely sleep on the same surface together, such as what occurs during bedsharing, even when all known adverse bedsharing risk factors are absent and safe bedsharing practices involving breastfeeding mothers are followed, an infant that dies while sharing a sleeping surface with his / her mother is labeled a SUID, and not SIDS.26 In this way the infant death statistics increasingly supplement the idea that bedsharing is inherently and always hazardous and lend credence, artificially, to the belief that under no circumstance can a mother, breastfeeding or not, safely care for, or protect her infant if asleep together in a bed.27 The legitimacy of such a sweeping inference is highly problematic, we argue, in light of the fact that when careful and complete examination of death scenes, the results revealed that 99 % of bedsharing deaths could be explained by the presence of at least one and usually multiple independent risk factors for SIDS such as maternal smoking, prone infant sleep, use of alcohol and / or drugs by the bedsharing adults.28 Moreover, this new ideology is especially troubling because it leads to condemnations of bedsharing parents that border on charges of being neglectful and / or abusive.

«The expert Advisory Council on the Misuse of Drugs conducted a thorough review of the evidence and concluded that no social or medical harm resulted from the use of Khat.»

This trial, which was intended to make better use of staff resources given the strains on the service, threw up impressive results — improving performance on drug haulages and other projects.

However, the BBC claims that the government's own drugs information panel has expressed concern about the use of drug testing in schools, citing Vivienne Edwards from the Advisory Council on the Misuse of Drugs as warning that such tests can undermine pupil - teacher relationships and should not be used a result of «complex» technical and ethical issues surrounding the idrugs information panel has expressed concern about the use of drug testing in schools, citing Vivienne Edwards from the Advisory Council on the Misuse of Drugs as warning that such tests can undermine pupil - teacher relationships and should not be used a result of «complex» technical and ethical issues surrounding the iDrugs as warning that such tests can undermine pupil - teacher relationships and should not be used a result of «complex» technical and ethical issues surrounding the issue.

According to emergency responders, as a result of the local ban on synthetic drugs and bath salts, (voted into law by the Saugerties Town Board on March 29, 2012), hospitalizations resulting from overdoses caused by the use of these substances have been significantly reduced.

Just last month GW announced the results of clinical trials which show that its super-strong, super-concentrated, 51 % THC skunk cannabis medicine Sativex has»... limited relevant adverse effects and - particularly reassuring - the drug does not appear to lead to withdrawal effects if patients suddenly stop using it.»

Such results would not only provide better understanding of drug adulteration, but would also be able to help determine whether providing users with results suggesting adulteration influence their decisions to continue use — an important facet for harm reduction.

«We had thought that previous trials may have been limited by their use of first - generation drug - eluting stents, but these results show CABG still leads to better outcomes.»

They are similar to prisons in that they result in concentrated settings of people who use drugs and, due to their ineffectiveness, result in alarming rates of drug relapse and disruption to people's social networks that accelerate their risk for negative consequences like overdose, death and infection with blood - borne viruses.

As a result, P - gp causes resistance of the diseased cells to a majority of drugs currently available for the treatment of cancer, as well as drugs used for treatment of infectious diseases like HIV / AIDS.

Dr Webb said: «The results of our latest study open up the possibility of designing new drugs that use the same means to attack E. coli, but in a more effective way.»

Researchers say the results provide information that the federal Food and Drug Administration's Center for Tobacco Products could potentially use to make future regulatory decisions for point - of - sale tobacco advertising.

It concluded that he had deliberately published false and misleading scientific reports and altered the results of experiments in order to discredit a drug used to treat morning sickness.

These improvements, he said, resulted in a greater reduction in net use of blood pressure drugs and lipid - lowering medications in the liraglutide 3 mg group than in the placebo group.

Preliminary results of the study were presented at a World Health Organization (WHO) evidence review group meeting, while UNITAID has issued a call for further research into the use of endectocide class drugs, of which ivermectin is currently the only one registered for human use, as new vector control tools in the fight against malaria and other mosquito borne disease.

Other research groups are also generating promising results through the use of drugs to convert white fat cells into brown fat and through discoveries of the pathways and hormones that control brown fat metabolism.

The 2010 results are based on an expert panel that was called upon to use participants» judgment to assess the relative harm of 20 different drugs.

Professor Michael Seckl, lead author from the Department of Surgery and Cancer at Imperial said: «Although these are very early - stage results, and are yet to be applied to patients in trials, they suggest the addition of a very cheap diuretic may extend the amount of time we can use the cancer drug erlotinib.

They also showed that they could manipulate Klotho expression pharmacologically using the anti-diabetic drug rosiglitazone, which resulted in decreased levels of Wnt5A.

Respondents in this year's survey pointed to five main causes of the field's less than favorable reputation: drug and product recalls such as the withdrawal of Avandia; safety issues such as the discovery of problems with raw material from China used in medical products; scandals, including evidence that pharmaceutical companies have failed to release data from trials whose results cast doubts on their drugs» safety and efficacy; lawsuits brought against companies that failed to warn patients of problems with their products; and ethical issues such as kickbacks for physicians promoting specific medications.

The Chilean Rose Tarantula is the source of an important protein used in drugs to stop atrial fibrillation, an abnormal heart rhythm, or cardiac arrhythmia, which can result in death.

Although results such as these are consistent with the gateway hypothesis, they do not prove that using marijuana causes the use of other drugs.

He has used the results to build drugs that bind so tenaciously to different enzymes» reactive forms — like a baseball clamped to a catcher's mitt — that the enzyme is essentially taken out of action.

The results of this study highlight the importance of the guidelines to avoid adverse events associated with benzodiazepine and related drug use.

A statin drug commonly used to lower cholesterol is not effective in reducing the number and severity of flare ups from chronic obstructive pulmonary disease (COPD), according to the results of a large multicenter clinical trial designed and directed by Gerard J. Criner, MD, Director of Pulmonary and Critical Care Medicine at Temple University Hospital in Philadelphia, PA..

The team's results uncover a previously unknown, complex genomic landscape of this cancer, which can be used to design new personalized drug regimens for SS patients based on their unique genetic makeup.

Together, these results support the use of the nuclear translocation of p38 and JNK as a novel drug target to treat various cancers and inflammation - induced diseases.

In the new study the pain killer Ibuprofen was used as a model substance for poorly soluble drugs and it was shown that crystallisation of the drug was completely supressed in the formulation, resulting in both a higher solubility and a three times faster dissolution rate of the drug.

«As a result, drugs are approved on the basis of studies of very narrow clinical populations but are subsequently used much more broadly in clinical practice,» Naci and Ioannidis point out.

When breast cancer is diagnosed, the drug regimen that the patient receives is based primarily on the results of a biopsy that is used to identify the type of tumor she has.

However, results of the four clinical trials published in the NEJM were used to support the regulatory filing submitted to the FDA by the drug's developer, Gilead Sciences, Inc..

A drug used to treat men with late - stage prostate cancer proved effective in stemming progression of the disease in research participants who had not yet received chemotherapy and extended their survival, according to results from a multi-national Phase III clinical trial led by the Knight Cancer Institute at Oregon Health & Science University (OHSU).