Sentences with phrase «used as a biomarker»
Its expression could be used as a biomarker test to ensure patients might benefit from an NPTX2 inhibitor, when one is developed.
https://www.sciencedaily.com/
Furthermore, PRL - 3 has the potential to be used as a biomarker in personalised therapy for AML patients.
In a study published in the May / June issue of mBio, an online open - access journal from the American Society of Microbiology, the researchers found that the microorganisms found in must — freshly - pressed grape juice, before fermentation — can be used as biomarkers to predict which metabolites will be found in the finished wine.
«Lastly, the technique we have pioneered will likely be a valuable tool for scientists and clinicians studying the biology of complex nanoparticle populations,» Dr. Zhang said, «and may aid in the development of diagnostic tests using them as biomarkers.»
The P4 medicine concept is fully realised in the context of Liquid Biopsy, since the patient's blood is used as a biomarker for the prognosis and diagnosis of the disease status.
Specific proteins and chemicals in the samples are used as biomarkers, or indicators of health.
Recent studies showed that optic nerve damage in glaucoma triggers the production of autoantibodies, which could be used as biomarkers to glaucoma early detection.
Aberrant expression of TUBB3 has also been found in various tumors of non-neural origin and can be used as a biomarker for cancer aggressiveness and a marker for the tendency to respond poorly to chemotherapy.
Moreover, this study will determine whether changes in retinal microvasculature can be used as a biomarker or clinical indicator for monitoring progression of glaucoma in clinical practice.
In a study involving 12 patients with bladder cancer, who also underwent prostate surgery as part of their treatment, she identified the ICOS molecule as the first immunologic marker identified in both tumor tissues and the systemic circulation that can be used as a biomarker for monitoring of anti-CTLA-4 treated patients as a possible marker of therapeutic activity.
So what we now want to pursue, now that we have that resolution, is to see how we can take advantage of that to study the function of the cell at that scale so that we can use that as a biomarker because many of the clinical measurements these days focus on structure and that is usually a very late indicator of the disease.
«The finding that soluble TREM2 has an important function supports its use as a biomarker for Alzheimer's,» adds Xu.
Identify circulating miRNAs that are altered in early AD, and could ultimately and reliably be used as biomarkers to monitor pathological changes in AD patients.
But Spector argues that EpiTwin has already made valuable contributions — for example, through a study of 15 twin pairs discordant for breast cancer that pointed toward hypermethylation of the DOK7 gene, which he believes could one day be used as a biomarker to help identify women at risk for breast cancer years in advance.
The SFN - NAC is not the only metabolite present in urine and, as along with DIM, could be used as biomarker of the consumption of cruciferous vegetables.
There was also a decrease in the depletion of DHEA, a hormone that is often used as a biomarker for aging [6].
Not exact matches
He is concerned that when biomarkers are used, other factors are ignored, such as what is happening in a person's life.
For researchers using mouse models to study a variety of cancers, including lymphoma, melanoma, breast, and prostate cancers as well as autoimmune and infectious diseases, the panel facilitates a highly sensitive and high - throughput investigation of biomarkers associated with disease progression.
The researchers also found that using physiological biomarkers, such as hormones from droppings, is an effective way of evaluating the impact of ecological and demographic factors on animal populations.
As Quintela says, if these data are confirmed, this genetic variant - present in 15 % of Caucasian people - could be used as a reliable biomarker in personalised medicine to select the best suited candidates to receive this druAs Quintela says, if these data are confirmed, this genetic variant - present in 15 % of Caucasian people - could be used as a reliable biomarker in personalised medicine to select the best suited candidates to receive this druas a reliable biomarker in personalised medicine to select the best suited candidates to receive this drug.
This new study of non-military, civilian trauma patients visiting the emergency department builds on recent research conducted by Dr. Samadani, supported through the Cohen Veterans Center, which found that the use of this novel eye - tracking technology could reveal edema, or swelling, in the brain as a potential biomarker for assessing brain function and monitoring recovery in people with head injuries.
«We hope that our work will provide the basis for a larger study of patient samples that may ultimately identify biomarkers that can be used as surrogate markers to determine the benefit of therapeutic interventions in diagnosed but asymptomatic HD patients to prevent or delay disease onset.»
The foundation's latest gift will fund the purchase of the Simoa technology and support Dr. de Leon's research to study its use as a potential biomarker for TBI.
«Adding these two biomarkers provided statistically significant improvement for all early stage cancer versus healthy controls as well as other subcohorts when used with the current gold standard biomarker, CA 19 - 9,» said Ann Killary, Ph.D., professor of Translational Molecular Pathology.
In the future, doctors could thus use Gab2 as a biomarker and infer the course of the disease by measuring Gab2 levels.
The biomarker, called phosphatidylethanol (PEth), could be used to screen young adults for harmful or heavy drinking such as binge drinking.
«Using a biomarker of heavy alcohol consumption such as PEth along with self - reporting could provide an objective measure for use in research, screening and treatment of hazardous alcohol use among young adults,» she said.
«Despite the identification of circulating tumor cells (CTCs) and cell - free DNA (cfDNA) as biomarkers capable of providing clinically relevant information in cancer patients, at present their identification is not routinely used in clinical practice,» explains Silvia Morbelli, MD, PhD, of the IRCCS San Martino — IST National Cancer Research Institute and University of Genoa in Genoa, Italy.
Co-researcher Dr Susan Francis, School of Physics, SPMIC added: «The team has a special interest in new types of functional MRI using novel targets like sodium as quantitative biomarkers of disease in the body, in particular in the kidney.
The technique of using sodium ions in the body as a biomarker for imaging is very challenging because of the lower detectability of the sodium signal in biological tissue by currently available MRI scanners.
The exact mechanisms must be probed in further animal studies, Reid says, but eventually he hopes researchers will be able to use a patient's bacterial makeup as a biomarker for cancer screening or to develop probiotics for improving prognosis and treatment outcomes.
The information potential held by miRNAs, combined with the fact that they are stable in serum and plasma, has led to a rapidly growing interest in using miRNAs in blood as diagnostic and prognostic biomarkers.
They found that in all nine cases, their data matched the outcomes seen in patients, as measured by clinical protein biomarkers found in the bloodstream, which are used by doctors to determine whether a drug is killing the tumor cells.
Using a simple genetic test, doctors could one day use CHL1 as a biomarker to determine whether or not to prescribe SSRIs.
Using hollow - core optical fibre as a sensitive gas cell, researchers in Japan have devised a relatively simple and affordable sensor for monitoring biomarkers in human breath at low concentrations.
This study looked at the use of head circumference and head tilting reflex as two biomarkers that can be used during well - baby visits by primary care providers.
This study looked at the use of head circumference and head tilting reflex as two biomarkers that can be used during their well - baby visits by their primary care providers.
«These splicing signatures could potentially be used as clinical biomarkers to detect blood stem cells that show signs of early aging or leukemia, and to monitor patient responses to treatment,» said Crews.
The researchers also are seeking other potential drug targets in the 50 percent of patients who don't have high levels of the anti-death protein, as well as biomarkers in addition to CA125 that could be used to screen for ovarian cancer.
If the findings hold up across different autoimmune diseases, it's possible that the characteristic patterns of Xist localization could be used as a disease biomarker, enabling earlier diagnoses and treatment.
The primary analysis assessed the outcomes of patients using an FDA - approved biomarker test, known as NEPHROCHECK ®, within the first day of arrival into the intensive care unit.
In one VA - funded study, he is using a type of electroencephalography (EEG)-- in which veterans wear an electrode - studded cap on their head — to trace brain patterns that may eventually serve as biomarkers.
It might be possible, in future, to use biomarkers to define patient subgroups and treat them with customised cancer therapy or to find new treatment options as an alternative to surgery.
«The findings advance our understanding of the role of lncRNAs in cancer biology and, importantly, broaden the opportunity to use lncRNAs as biomarkers to detect prostate cancer.»
When such a biomarker test is perfected, it could be used not only to distinguish pancreatic cancer from chronic pancreatitis, but, potentially, as a screening test for patients at high risk for pancreatic cancer, Dr. Raimondo says.
«This suggests that using epigenetics as a biomarker could give you a lot of information about environmental exposures within particular populations that's not captured by genetics,» Zaitlen said.
They also speculated that the biomarker could be used as a tool in the clinical diagnosis of people with autism spectrum disorder.
His laboratory is also keenly interested in utilizing high - throughput proteomic approaches for the discovery of biomarkers for diseases such as cancer and exploring the use of proteomic and metabolomic technology for the routine interrogation of clinical samples.
«This way,» he says, «we can start to evaluate the use of various compounds as biomarkers and indicators of patient recovery.»
«Future research will focus on optimizing the candidate therapies discovered by our team in this study as well as developing biomarkers that can be used to test the efficacy of other potentially promising drugs,» says Dr. Rothstein