Sentences with phrase «used as a tumor»

Nagalase is used as a tumor marker, a marker of inflammation, and a marker of bacterial infection.

Not exact matches

Hispanics in California split a long chile pod, boil it and use it as a poultice for swollen glands or to draw out pus from a tumor.

Similar drugs are used clinically as antidepressants, the authors write, and their effects on tumors in clinical settings are being investigated.

They discovered edelfosine, which has been FDA - approved as an investigational leukemia treatment, and has also been used in clinical research for primary brain tumors.

For some years now, a new class of drugs called antibody - drug conjugates (ADCs) have been used, which work in two ways: they consist of an antibody that binds selectively to the tumor cell receptor and interrupts the signal to propagate; they also act as a transport vehicle for a chemical substance that enters the cancer cells with the antibody and triggers their death.

Currently, rising blood levels of prostate - specific antigen (PSA), a protein made by the prostate gland, are used as indicators of tumor recurrence.

Inspired by his own bout of leukemia to try to find a better cancer treatment, retired broadcasting station owner Kanzius guessed that as an alternative to chemotherapy, he could inject tumors with metal ions, then use radio waves to heat the metal and destroy cancerous cells.

Another possible application for the new machine is generating peptides that could be used as personalized cancer vaccines targeting unique proteins found in individual patients» tumors.

«We know that 70 - 75 percent of glioblastoma patients undergo surgery for tumor debulking, and we have previously shown that MSCs encapsulated in biocompatible gels can be used as therapeutic agents in a mouse model that mimics this debulking,» he continued.

Antimatter has even been used as a medical diagnostic tool in positron - emission tomography, which uses positrons to find tumors.

Researchers found that a combination of drugs — one targeting epidermal growth factor receptor (EGFR) and one targeting tumor necrosis factor (TNF)-- effectively blocks the cancer from using TNF as an escape route.

«We used the algorithms to identify typical molecular signatures of stem cells [stemness signatures] that could help us understand tumors and serve as predictors of aggressiveness or clinical outcome.»

Researchers are already using single - cell analysis to identify genetic variations within tumors and tissues, and Langsdorff says the technique is quickly establishing a foothold in microbiology as well.

(Mackenzie notes that it shouldn't be a problem for her strategy, because she plans to use the same kind of cells as bone marrow transplants, which haven't caused tumors.)

Plasma samples of patients with NSCLC is a less invasive method and has been used as surrogate tumor tissues for detecting genetic alterations.

After years of speculation about the promise of cancer vaccines as a way to use the immune system against tumors, the United States will soon see its first cancer vaccine hit the market.

The first - in - human PET / CT imaging of 75 patients with 18F - MPG was performed to show that this tracer can be used as a companion diagnostic to identify NSCLC patients with EGFR activating mutant tumors (primary tumor or metastatic) with 84.3 % accuracy.

After more than six years of research, the research team led by María Soengas, head of CNIO's Melanoma Group, showed that RAB7 acts as an orchestra director, determining the fate of melanoma cells: at high concentrations of RAB7, cellular autodigestion is very active, and this allows tumor cells to obtain energy, prevent the accumulation of toxic components and thus divide and proliferate; when RAB7 is reduced, cells use endosomes to recycle metastatic proteins, favouring their dispersal throughout the body.

Using tumor samples from the Women's Healthy Eating and Living clinical trial, researchers identified stem - like tumor cells as being characterized by low levels of the molecule p53 upregulated modulator of apoptosis (PUMA).

These drugs are also frequently used to manage central nervous system (CNS) disorders associated with a pathologically permeable BBB, such as with brain tumors and multiple sclerosis.

The researchers used an example to demonstrate the mechanism: They identified the transcription factor STAT3, which regulates inflammatory processes and can promote tumor development, as a prominent target protein of one peroxiredoxin.

«Despite the identification of circulating tumor cells (CTCs) and cell - free DNA (cfDNA) as biomarkers capable of providing clinically relevant information in cancer patients, at present their identification is not routinely used in clinical practice,» explains Silvia Morbelli, MD, PhD, of the IRCCS San Martino — IST National Cancer Research Institute and University of Genoa in Genoa, Italy.

Doctors already test breast tumors for Ki67 levels, which can inform decisions about treatment, but this is the first time scientists have been able to link Ki67 to precancerous tissue and use it as a predictive tool.

Introduced in 2007 and initially used to destroy tumors, the Visualase system was first employed as a treatment for epilepsy in 2010.

«As there are no published guidelines for the use of ctDNA for EGFR mutation analysis in the absence of tumor tissue, these results may help address this current unmet need.»

Using a fluorescent protein to detect Rgs16 expression, the investigators found that this gene is induced by pancreatic tumor formation starting from its earliest manifestation as ductal neoplasm all the way to advanced solid tumor in a spatially and temporally coincidental manner.

Some cell types were not killed by treatment with PAL, suggesting it could be used as a specific tumor therapy.

The ability to track tumor cells in the bloodstream based on genetic content located within the cell itself, as opposed to using proteins located on the cell's surface (current technology)

In the past few years, Vogelstein and Kinzler have shifted away from discovering new cancer genes to a less glamorous pursuit: using genetic tests to detect common tumors as early as possible, when they are easiest to cure.

One adaptation to this fortunate reality is that rather than using overall survival (OS) as the measure of a drug's success, many clinical trials now use a kind of midpoint, namely progression - free survival (PFS)-- the time that it takes for a tumor controlled by the trial's medicine to restart its growth.

Several days after imaging, the patient underwent brain surgery; using the images as a guide, surgeons safely removed most of her tumor.

«Our findings have potential for targeting local, as well as metastatic tumors, and future studies will use FDA - approved drugs to induce Par - 4 secretion.»

As proof - of - principle of the potential efficacy, Zhang's team grew human ovarian tumors in immunocompromised mice, then injected short - interfering RNAs to block the tumors» growth using RNA interference against FAL1.

It's a popular goal in nanotechnology these days: using tiny particles as containers to ferry drugs to tumors, among other targets.

Surgeons use this procedure, known as «sentinel lymph node mapping,» to determine the extent of cancer metastasis after removing a tumor.

They found that in all nine cases, their data matched the outcomes seen in patients, as measured by clinical protein biomarkers found in the bloodstream, which are used by doctors to determine whether a drug is killing the tumor cells.

This may allow surgeons to look at the perimeter of a growing tumor and use the shape to guide their assessment of which regions could be more problematic — where they need to take out more tissue around the tumor and where they may not need to take as much.»

Reactivation of HBV may occur with chemotherapy, organ and tissue transplantation, High dose corticosteroids, and biologicals targeting tumor necrosis factor - alpha (TNF - α), Anti-TNF medications are used in treating rheumatic diseases, such as rheumatoid arthritis, digestive conditions that include Crohn's and colitis, and dermatologic conditions, such as psoriasis.

In some cases such as ovarian cancer, however, drug - free intervals are needed to allow patient recovery from side effects, during which tumors can sometimes begin to grow again or develop resistance to the drugs being used.

Rather than simply identifying a cancer by location or tissue type, researchers now use advanced molecular profiling tests to characterize tumors, the proteins they express and the novel mutations they develop — known as neoantigens.

Over the past two years, investigators from the Perelman School of Medicine at the University of Pennsylvania have reported results from a human trial in GBM using chimeric antigen receptor (CAR) T cell therapy, through which patients» own T cells were engineered to track down and kill cancer cells that express a tumor - specific protein known as EGFRvIII.

Indeed, as he and his colleagues went on to report, the 217 microRNAs that had been identified to date could be more effective at classifying tumors than the 20,000 protein - coding RNAs already used for diagnosis.

Researchers in Sweden sought to determine if use of tumor necrosis factor inhibitor drugs to treat RA would result in a reduced risk of acute coronary syndrome (commonly called ACS), defined as a diagnosis of a heart attack or unstable angina (the worsening or increasing cardiac symptoms)

Their recent study, which appears as the cover article in the May issue of Cancer Research, shows that mathematical models can be used to predict how different tumor cell populations interact with each other and respond to a changing environment.

Immune cell therapies using engineered T - cells have recently emerged as successful treatments for some blood cancers, which are referred to as «liquid» tumors.

Set up as a mock - trial, the session was designed to examine the increasingly common dilemma of whether evidence such as MRI images, which can be used to see damage in the brain such as lesions or tumors, should be entered into court cases.

That may be great if you are using carbon nanotubes to deliver chemotherapy drugs to people with brain tumors, as cancer researchers in California (at City of Hope, a cancer research and treatment center in Duarte in collaboration with NASA's Jet Propulsion Laboratory in Pasadena), hope to do.

Looking forward, Gimi's work will focus on using these microencapsulated cells to stimulate the immune system to act against tumors, as well as activating drug synthesis.

In theory, superparamagnetic particles could be ideal for drug delivery, as they can be directed to a tumor simply by using a magnetic field.

To see if texaphyrins gravitate to tumors just as their porphyrin cousins do, Sessler used magnetic resonance imaging (MRI) to scan cancerous mice before and after a texaphyrin injection.