Sentences with phrase «used by cancer cells»

p. 187), recent research shows that celery contains high levels of the bioflavonoid apigenin which inhibits cancer growth by reducing the amount of a specific enzyme used by cancer cells.

Ketones, on the other hand, can't be used by cancer cells as an energy source.

Cancer Research UK scientists have discovered a new line of defence used by cancer cells to evade cell death, according to research published in Nature Communications.

«Scientists pinpoint a new line of defense used by cancer cells.»

The PKCƐ signal pathway, which is used by cancer cells but rarely by normal cells, could be important in targeting some cancer cells as they rely on this pathway to survive.

Targeting stromal cells as well as the cancer cells blocks multiple cell signalling pathways that are used by cancer cells to become aggressive.

Excess aminos — typically the end result of metabolic processes stimulated by the stress - induced release of adrenal hormones — will be available for use by cancer cells].

Not exact matches

Chicago, GenomeWeb — A new study by researchers from Memorial Sloan Kettering Cancer Center has demonstrated the predictive power of an AR - V7 protein expression test using Epic Sciences» non-EPCAM-based circulating tumor cell detection platform, which could help guide treatment decisions for men with metastatic castration - resistant prostate cCancer Center has demonstrated the predictive power of an AR - V7 protein expression test using Epic Sciences» non-EPCAM-based circulating tumor cell detection platform, which could help guide treatment decisions for men with metastatic castration - resistant prostate cancercancer.

Currently marketed for research use by Biofluidica, the test's microfluidic channels use specific cancer antibodies to detect capture circulating tumor cells.

TruePrime LB addresses current liquid biopsy sensitivity and specificity issues by using adapted amplification of cancer - specific, large - fragment, cell - free DNA based on primer - free technology that combines the enzymes TthPrimPol and Phi29 DNA polymerase.

«Used in cancer therapy, this process could increase the impact of a treatment by heating the cancer cells while introducing the drug compound into the tumor.»

The compound (right panel) has a scorpion - like shape with two arms grabbing EphA2 - expressing cancer cells, and a tail (brown) constituted by a cytotoxic chemotherapeutic agent (paclitaxel used in this work).

A route used by tumor cells to spread could be exploited to make stem cells for regenerative medicine and cancer therapies

Doxorubicin is a chemotherapy drug used to treat a wide range of cancers by preventing cancer cells from replicating.

Inspired by his own bout of leukemia to try to find a better cancer treatment, retired broadcasting station owner Kanzius guessed that as an alternative to chemotherapy, he could inject tumors with metal ions, then use radio waves to heat the metal and destroy cancerous cells.

«Overall, our studies show that by using modified techniques we will be able to observe non-uniform cancer cells, regardless of their origin,» Polo - Parada said.

Dr Claudia Wellbrock, study author and Cancer Research UK scientist at The University of Manchester and a member of the Manchester Cancer Research Centre, said: «We used to think that cancer cells spread by first specialising in invading other parts of the body and then change in order to grow raCancer Research UK scientist at The University of Manchester and a member of the Manchester Cancer Research Centre, said: «We used to think that cancer cells spread by first specialising in invading other parts of the body and then change in order to grow raCancer Research Centre, said: «We used to think that cancer cells spread by first specialising in invading other parts of the body and then change in order to grow racancer cells spread by first specialising in invading other parts of the body and then change in order to grow rapidly.

The cancer cell does so by forming short - lived invadopodia — foot - like protrusions these cells use to invade.

The use of proteasome inhibitors to treat cancer has been greatly limited by the ability of cancer cells to develop resistance to these drugs.

Chinnaiyan and colleagues then conducted studies using cancer cells and found that the different FGFR fusion proteins all seemed to drive cancer cell proliferation by activating FGFR signaling.

«Mechanisms cancer cells use to establish metastatic brain tumors revealed by research.»

A «Trojan horse» treatment for an aggressive form of brain cancer, which involves using tiny nanoparticles of gold to kill tumour cells, has been successfully tested by scientists.

«If you give patients immune cells to eradicate any remaining cancer cells that might be present,» he says, «those immune cells would not be prevented from doing their job by ongoing immune suppression drugs that are being used in patients treated with conventional transplant approaches.»

Developed by Amgen, it uses a modified version of the herpes virus that can't infect healthy tissue but attacks cancer cells.

Now, in a new study using laboratory - grown cells and mice, Johns Hopkins scientists report that a method they used to track metabolic pathways heavily favored by cancer cells provides scientific evidence for combining anti-cancer drugs, including one in a nanoparticle format developed at Johns Hopkins, that specifically target those pathways.

But their overriding interest in BPTES, says Slusher, was in how it works: by blocking the production of glutamine, an amino acid that acts as a building block of cells and is used frequently by pancreatic cancers to create more cancer cells.

By using «gemcitabine» chemotherapy to target cancer cells, and a form of vitamin A to target the surrounding stromal cells, the combined approach led to a reduction in cancer cell proliferation and invasion.

«This could be useful in developing new combination therapies, where multiple drugs are used simultaneously to treat a cancer by attacking different parts of the cancer cells at the same time.»

Using the same computer - based approach, the team has now been able to target the c - FLIP (cellular FLICE [FADD - like IL - 1β - converting enzyme]- inhibitory) protein, known to play a key role in cancer stem cell maintenance and survival, described in previously published work by the Institute.

Treatment for advanced melanoma has seen success with targeted therapies — drugs that interfere with division and growth of cancer cells by targeting key molecules — especially when multiple drugs are used in combination.

Qingdong Zheng, a materials scientist at John Hopkins University in Baltimore, Maryland, suggests that such biolasers could find uses in new types of sensors or in light - based therapeutics, in which light is used, for example, to kill cancer cells by triggering drugs into action that have already been administered.

Autophagy has emerged as a key pathway that cancer cells use to survive in the face of assault by chemotherapy and radiation; however, autophagy as a potential druggable mechanism in patients who become resistant to BRAF inhibitors has not been investigated.

To see whether cancer stem cell renewal involves a chain of events similar to that used by embryonic stem cells, and whether the process was affected by oxygen levels, Semenza and graduate student Chuanzhao Zhang focused their studies on two human breast cancer cell lines that responded to low oxygen by ramping up production of the protein ALKBH5, which removes methyl groups from mRNAs.

This widespread lack of the need for telomerase is used by evolution as a key component of our defense against cancer, because having a limit to the size and renewal of telomeres prevents our cells from replicating themselves indefinitely — the crucial hallmark of cancer.

Saatchi, which is owned by France's Publicis Groupe, SA, chose LifeStraw over a field of competitors that included a reusable controller to improve the distribution of IV fluids, a collapsible wheel that can be folded down for easier storage when not in use on bicycles or wheelchairs, an energy - efficient laptop designed for children in developing countries, a 3 - D display that uses special optics and software to project a hologramlike image of patient anatomy for cancer treatment, an inkjet printing system for fabricating tissue scaffolds on which cells can be grown, a visual prosthesis for bypassing a diseased or damaged eye and sending signals directly to the brain, books with embedded sound tracks to help educate illiterate adults on health issues, a phone that provides telecommunications coverage to poor rural populations in developing countries, and a brain - computer interface designed to help paralyzed people communicate via neural signals.

Slusher teamed up with Johns Hopkins Kimmel Cancer Center immunologist Jonathan Powell, M.D., Ph.D., who has studied how cancer cells use different metabolic pathways to evade destruction by immune Cancer Center immunologist Jonathan Powell, M.D., Ph.D., who has studied how cancer cells use different metabolic pathways to evade destruction by immune cancer cells use different metabolic pathways to evade destruction by immune cells.

Our new findings tell us that low oxygen conditions actually encourage certain cancer stem cells to multiply through the same mechanism used by embryonic stem cells.»

Cancer cells survived longer by using the UPR to suppress Bmal1 and short - circuit their circadian rhythms.

However, the use of NF - kB inhibitors in treating cancer is complicated by severe side effects related to immunosuppression caused by indiscriminate inhibition of NF - kB in normal immune cells.

«We hope that by using these computational approaches to understanding cancer cell systems, we've widened the field for finding the new desperately needed cancer drugs,» said Dr Módos.

The proposed clinical trial, in which researchers would use CRISPR to engineer immune cells to fight cancer, won approval from the Recombinant DNA Advisory Committee (RAC) at the U.S. National Institutes of Health, a panel that has traditionally vetted the safety and ethics of gene therapy trials funded by the U.S. government and others.

Aware that cancers rewire their metabolism in ways that could change the epigenome and that distant metastases in pancreatic cancer naturally spread to organs fed by a sugar - rich blood supply, the researchers wondered if the tumor cells had altered the way they use the basic form of sugar, glucose.

The researchers, who released their findings in Cancer Prevention Research Journal, published by the American Association of Cancer Research, used a visualization technique — immunofluorescence — to identify stem cells in the colon of pigs that were fed either a high calorie diet or a standard diet.

Researchers used IL - 15 to develop a whole tumor cell vaccine to target breast (TS / A) and prostate (TRAMP - C2) cancer cells in animal models; results showed that tumor cells stopped growing after the vaccine was introduced and that beneficial effects were enhanced further when IL - 15Rα was co-produced by the vaccine cells.

«Obviously, this information can be used in our efforts to identify drug therapies that kill cancer cells by targeting telomerase activity.»

These diets may naturally be providing a shotgun approach to cancer prevention by using a wide variety of beneficial compounds to target multiple pathways that cancer stem cells use to survive.

New results from a clinical trial involving more than 900 military veterans at high risk for keratinocyte carcinoma skin cancer provides evidence that using the generic skin cream fluorouacil 5 percent for two to four weeks may reduce the risk of a squamous cell carcinoma (SCC) needing surgery by 75 percent within a year.

The researchers tested two anti-CK2 drugs for their ability to stimulate the production of new brown fat in mice: a new small - molecule CK2 - blocker called silmitasertib (CX - 4945), which is already in clinical trials as a cancer therapeutic; and a more precise next - generation antisense oligonucleotide (ASO) drug developed in collaboration with Isis Pharmaceuticals, which eliminates CK2 by blocking the RNA instructions cells use to produce it.

A team of researchers in Germany and Denmark led by Steven Johnsen, Professor at the University Medical Center Göttingen, Germany, used human prostate cancer cell lines and depleted them of the DNA - binding protein CHD1.

By using molecular genetic tools to reduce the amount of PC in human lung cancer cells, the team observed decreased cell growth, a compromised ability to form colonies in soft agar (a gelatinous material specifically used to grow bacteria and other cells), and a reduced rate of tumor growth in mice.