Sentences with phrase «used cell signaling»

In the new study, Bohn's group used cell signaling assays on a library of µ - receptor - activating compounds to find a few with hints of a bias toward G - protein signaling.

CHIP — quantitative real - time fluorescence PCR (qPCR) was performed using Cell Signaling SimpleChIP Plus Enzymatic Chromatin IP Kit (# 9005) according to the manufacturer's instructions.

Not exact matches

In the end, the committee's advisory report recommended tracking all drones, using a mix of radio and cell tower signals to continuously monitor more sophisticated ones, while less sophisticated drone models could be tracked intermittently through software modifications.

When a GPS signal is unavailable, geolocation apps can use information from cell towers to triangulate your approximate position, a method that isn't as accurate as GPS but is has greatly improveds in recent years.

And, perhaps most strikingly, a team at a gaggle of New York research institutions published a paper showing how they'd used hPSCs to cook up — in just days, rather than several months — cortical neurons (critical central nervous system cells) that had normal electrophysiological signaling properties.

To build nationwide 5G, they either have to kick current customers off LTE, which would take years, or use a type of spectrum (millimeter wave) that can only carry a signal 2,000 feet from a cell site — versus multiple miles for other spectrum — making it nearly impossible for either of them to create a truly nationwide 5G network quickly.

JCAR017 uses a defined CD4: CD8 cell composition and 4 - 1BB as the co-stimulatory signaling domain to mimic a «second signal» that amplifies the activation of CAR T cells, which according to Juno leads to a more robust signal to the T cell to multiply and kill the cancer cell.

Older wireless receivers used analog signals, but these are open to interference from other wireless devices like cell phones, cordless land line phones, radios, etc..

The NYPD is one of many police departments across the country quietly using a highly secretive military grade technology that can track the whereabouts of suspects by using their cell phone signals.

Improved understanding of the biology of cancer cells has led to the development of biological agents that mimic some of the natural signals that the body uses to regulate growth.

The researchers used a drug called clorgyline to inhibit the activity of the MAOA enzyme; the drug disrupted the signaling system that led to cancer cell invasion and proliferation.

With an existing method, they used specific chemical signals to «guide» the stem cells into becoming cells that have the potential to become sperm.

Mitochondria, specialized organelles found in nearly every cell of the body, use cellular respiration to generate one of the most important sources of chemical energy — adenosine triphosphate (ATP), a versatile nucleotide that powers everything from cell division to cell signaling to transportation of large molecules across the cell membrane.

Kwiizya uses this Wi - Fi network to relay a cell signal.

Researchers there are examining the role of other signaling factory beyond BMP as well as conducting further studies using human cells and human scar tissue.

Taking a closer look, the team found that the onset of sepsis disrupts the normal activity of specific interferons, signaling proteins used for communication between immune system cells.

This is because rat neurons are much more efficient at pumping ions into the cell than squid neurons, say the team, resulting in squid using up more energy to generate a charge and transmit the signal.

A nerve cell, which sends signals using serotonin, first releases serotonin into the space between the nerve cells.

As they fall deeper into the dark between the stars, the light sails would attempt to transmit their precious findings back to Earth using laser beams no more powerful than the signal from a typical cell phone.

For some years now, a new class of drugs called antibody - drug conjugates (ADCs) have been used, which work in two ways: they consist of an antibody that binds selectively to the tumor cell receptor and interrupts the signal to propagate; they also act as a transport vehicle for a chemical substance that enters the cancer cells with the antibody and triggers their death.

Deep brain stimulation is used in Parkinson's disease to trigger brain cell activity and prevent the abnormal signalling that causes debilitating tremors, but placing the electrodes required is highly invasive.

Chinnaiyan and colleagues then conducted studies using cancer cells and found that the different FGFR fusion proteins all seemed to drive cancer cell proliferation by activating FGFR signaling.

«Our studies suggest that the local auxin signals can be communicated over long distances using calcium waves in order to generate an auxin signal also in target cells located far away,» Hedrich says.

«That upheld our hypothesis, which was that biochar could interfere with cell signaling, most likely by binding with the fatty - acid molecules that the speakers were using to broadcast their message.»

The network provides an invaluable resource for identifying targets to treat the disease and has been used to implicate a particular signaling pathway involved in cell motility.

The researchers found that, in response to the maximum tolerated doses of several commonly used chemotherapy drugs, breast cancer - associated fibroblasts secrete large amounts of cell signaling proteins called ELR + chemokines.

In particular, HD mutations impacting the RhoGTPase signaling pathway interfered with filopodia, the slender projections that cells use to direct movement and communicate with other cells.

King hypothesizes that proteins that the single - celled ancestors of animals used to interact with the extracellular environment — to capture bacterial prey by binding to their cell surface and to detect chemical signals — were later repurposed to enable cells to stick to and talk to each other.

We can bypass damaged cells using light to signal output neurons directly.

Designed for use in spinal fusion surgery of the lower back, Infuse consists of a titanium cage that houses a collagen sponge soaked in bone morphogenetic protein (BMP), a growth factor that signals bone - forming cells to produce new tissue.

Targeting stromal cells as well as the cancer cells blocks multiple cell signalling pathways that are used by cancer cells to become aggressive.

Kilian said these questions range from the basic — how macrophages signal to the breast cells — to the more long - term: Can therapeutics be used to disrupt that communication?

In order to survive, early single - celled organisms could have used that signal to direct repair, an evolutionary advance that he thinks survives today.

The brain uses the chemical to communicate between cells, and dopamine signals different events depending on its location.

A recent study from the Tel Aviv University School of Engineering used the signal strength from cell phone base stations to monitor the intensity of rainfall in those exact locations.

Incoming sound waves make the eardrum vibrate, and the eardrum delivers these vibrations using the ossicles to the inner ear where hair cells translate them into electric signals sent to the brain.

Using a laptop computer equipped with a wireless transmitter, a researcher stimulated cortical cells governing whisker sensations and reinforced those signals by zapping the rats» pleasure centers.

«Tumor cells produce larger quantities of H2O2 and use oxidative signals at higher levels than normal cells in order to drive their own growth,» says Mirko Sobotta, first author of the publication.

In the flightless Orai mutant flies, SOCE was inhibited in a set of cells called «dopaminergic interneurons» — nerve cells that used dopamine to relay signals.

The same signals that embryonic cells use to decide whether to become nerves, skin or bone come into play again when adult animals are learning whether to become afraid.

Riffell and his colleagues hope these nerve cell recording experiments will help them understand how insects integrate and interpret different signals from their environment and use this information to make decisions.

The group has already started tweaking human iPS cells using the same genes that Saitou pinpointed as being important in mouse germ - cell development, but both Saitou and Hayashi know that human signalling networks are different from those in mice.

In this study, the team, which included Dr. Meerim Nurbaeva and Miriam Eckstein in Dr. Lacruz's lab, for the first time used freshly dissected enamel cells (ameloblasts) from rodent teeth to modulate physiological processes in order to understand the contribution of CRAC channels in enamel calcium signaling.

Calcium is a «promiscuous» signal used by all cells for a wide variety of processes, he notes, and thus drugs that target it could have major side effects.

Researchers used the new therapy to inhibit a pathway in the cancer cells known as mTOR signaling — putting the brakes on this pathway, combined with the current standard therapy, caused more of the cancer cells to die.

Trametinib is used to treat skin cancer and was chosen for its ability to inhibit Ras signalling as part of the «Ras - Erk - ETS» cell pathway.

This method makes it possible to chronologically pinpoint which signals nerve cells use to respond to a pain stimulus.

Intriguingly, even mammalian cells have been shown to respond to serum produced by post-feeding pythons, suggesting that the signaling function is conserved across species and could one day be used to improve human health.

Saatchi, which is owned by France's Publicis Groupe, SA, chose LifeStraw over a field of competitors that included a reusable controller to improve the distribution of IV fluids, a collapsible wheel that can be folded down for easier storage when not in use on bicycles or wheelchairs, an energy - efficient laptop designed for children in developing countries, a 3 - D display that uses special optics and software to project a hologramlike image of patient anatomy for cancer treatment, an inkjet printing system for fabricating tissue scaffolds on which cells can be grown, a visual prosthesis for bypassing a diseased or damaged eye and sending signals directly to the brain, books with embedded sound tracks to help educate illiterate adults on health issues, a phone that provides telecommunications coverage to poor rural populations in developing countries, and a brain - computer interface designed to help paralyzed people communicate via neural signals.

To unravel the complex journey of the body's GPCRs, scientists used biophysical tools, including fluorescent biosensors; biochemical tools, such as cell signaling in neuronal cultures; as well as computational models.