Sentences with phrase «used gene delivery»
Dr. Rex used gene delivery to provide long - term production of a modified form of erythropoietin (EPO), a hormone that induces red blood cell production but is also a neuroprotective cytokine.
https://www.glaucoma.org/ Not exact matches
Gene therapy involves the delivery, using a modified virus, of a healthy copy of a gene to make up for one that's deficient in a way that causes diseGene therapy involves the delivery, using a modified virus, of a healthy copy of a gene to make up for one that's deficient in a way that causes disegene to make up for one that's deficient in a way that causes disease.
To use viruses as delivery vehicles for gene therapy, researchers take all the harmful and replicative genes out of the virus and put in the therapeutic genes they want to deliver.
Muscle biologists Qi Long Lu and Terence Partridge at the Medical Research Council Clinical Sciences Centre in London, U.K., and their colleagues decided to combined the antisense strategy with a chemical often used in gene therapy because it is known to improve delivery of DNA into cells.
«To date, this type of system has only been used in humans with viral methods of gene delivery, of which the safety profiles are still heavily in debate,» says Betty Tyler, associate professor of neurosurgery at Johns Hopkins.
Dr Wenxin Wang is trying to uncover therapies for diseases such as diabetic ulcers and Epidermolysis Bullosa, which causes chronic skin conditions: «We are currently investigating the use of these new materials for biomedical applications such as drug / gene delivery, cross linkable hydrogel materials and skin adhesives.
Using molecular scissors wrapped in a greasy delivery package, researchers have disrupted a gene variant that leads to deafness in mice.
Yehoash Raphael, an auditory neuroscientist at the University of Michigan, Ann Arbor, says the findings provide a new delivery model for researchers trying to use developmental genes to restore lost hearing.
Lombardo A, Genovese P, Beausejour CM, Colleoni S, Lee YL, Kim KA, Ando D, Urnov FD, Galli C, Gregory PD, Holmes MC, Naldini L. Gene editing in human stem cells using zinc finger nucleases and integrase - defective lentiviral vector delivery.
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New delivery technique used to create a glowing adult mouse potentially opens the door for in vivo gene therapy
To use viruses as delivery vehicles for the gene therapy, the researchers took all the harmful genes out of the virus and put in the beneficial genes in.
The variety of new tools available for genetic manipulation now include lentiviral - based gene delivery, and gene editing using CRISPR / Cas9, zinc finger nucleases (ZFNs) or transcription activator - like effector nucleases (TALENs).
We have demonstrated that our liposomes can mediate in vivo target mRNA delivery as well as gene disruption using an entirely RNA - based approach.
By eliminating HIV's ability to replicate (a feat accomplished in the mid 90s), Dr. Verma's group created a vector, or carrier, that is now used worldwide for gene delivery.
LA JOLLA, CA — Using a gene therapy delivery system developed in the laboratory of Inder Verma at the Salk Institute for Biological Studies, an international team of researchers successfully treated two...
Dr. Verma's group created a vector, or carrier, that is now used worldwide for gene delivery.
Nanoparticles conjugated with two active ligands, one for its effective uptake and the other for it's binding or use to gene delivery agents to deliver drug inside cells.
Because of their unique properties such as monodispersity, large surface area and high drug loading efficiency, silica nanoparticles (SiNPs) have been developed for a vast array of biomedical uses such as optical imaging, cancer therapy, targeted drug delivery and controlled drug release for genes and proteins.
Meanwhile, gene delivery systems other than retro - or lenti - viral ones, such as repeated transfection with plasmids and use of a non-integration virus, have been successfully applied in generation of iPS cells [8], [9].
The use of viral vector for mouse mutagenesis and / or for delivery of gene editing by nuclease (F. Piguet, IGBMC)
Particle bombardment, also known as gene - gun or ballistic gene delivery, uses heavy - metal particles to propel naked DNA plasmids into target cells.
These alternate strategies include using small - molecule drugs that affect RNA metabolism or protein stability, as well as administering modified viruses for therapeutic gene delivery (see «Getting a fix on SMA»).
The Magnetofection Method: Using Magnetic Force to Enhance Gene Delivery.
The image shows green fluorescent protein (GFP) in the mouse cerebellum after delivery of the GFP gene using AAV - PHP.
Duan also provided significant expertise from a long history of work on gene therapy for neuromuscular disorders.To use viruses as delivery vehicles for gene therapy, researchers take all the harmful and replicative genes out of the virus and put in the therapeutic genes they want to deliver.
Mooney uses the results from these studies to design and synthesize new biomaterials that regulate the gene expression of interacting cells for a variety of tissue engineering and drug delivery projects.