Sentences with phrase «used in animal models»

One potential reason for this discrepancy is that the laboratory tests used in animal models of the disease do not resemble the clinical assessments given to patients, and thus are not predictive of human memory performance.

Warden C.H. and Fisler J.S. Comparisons of diets used in animal models of high - fat feeding.

Examples of funding areas include but are not limited to molecular genetic analysis of relevant neural circuit assembly and function; genetic and epigenetic research; animal models created by genetically altering neural circuits; and testing of new chemical entities that might be used in animal models as exploratory treatments.

BPTES has been used in animal models for a variety of cancers but has not substantially reduced tumor sizes, probably because the drug concentration in tumor tissue is not high enough when using conventional drug formulation methods, say the scientists.

Using the same noninvasive procedure she used in the animal model, McFarlin detected collagen changes in the cervix before the cervix shortened in women destined to give birth prematurely.

They initiated their Phase 1 BIIB054 trial in 2015, and reported promising early results of its use in an animal model of Parkinson's back in the summer of 2016, but have never published the results, issued press releases, or held conference calls to share their findings with the wider public.

Not exact matches

Dihydrocaffeic acid and malvidin - 3» - O - glucoside were used as a «prophylactic and therapeutic» treatment in an animal model.

Studies show that these models can accurately predict the ways that new drugs will react in the human body and replace the use of animals in exploratory research and many standard drug tests.

Using gene editing to create rodents that are ideal research models could narrow the genetic divide between humans and their animal stand - ins.

These findings allowed researchers to create a chimera virus: a mouse virus with a human viral gene that can be used to test molecules that inhibit human LANA protein in an animal model of disease, treating not only human herpes virus infection but also its associated cancers.

«Autism's social deficits are reversed by an anti-cancer drug: Using an epigenetic mechanism, romidepsin restored gene expression and alleviated social deficits in animal models of autism.»

In the lab, researchers will try to re-create the Thai results in monkeys to validate a new animal model using multiple low doseIn the lab, researchers will try to re-create the Thai results in monkeys to validate a new animal model using multiple low dosein monkeys to validate a new animal model using multiple low doses.

In animal models, the researchers found that using microRNA to disrupt cells in the brain's prefrontal cortex — a region associated with complex planning and decision - making — affected learning and memory later in lifIn animal models, the researchers found that using microRNA to disrupt cells in the brain's prefrontal cortex — a region associated with complex planning and decision - making — affected learning and memory later in lifin the brain's prefrontal cortex — a region associated with complex planning and decision - making — affected learning and memory later in lifin life.

He generates three - dimensional computer models of animals using a micro-CT scanner, which works in a similar way to a medical CT scanner but is designed for investigating small objects.

To demonstrate the effects of bullying, the researchers used an animal model simulating the physical and emotional stressors involved in human bullying — chronic social defeat stress.

Ellen Heber - Katz, a scientist at The Wistar Institute in Philadelphia, used to study autoimmunity — that was until she noticed something strange in the mice she was using to model lupus: The small holes that she had poked in their ears to distinguish the animals from one another kept closing.

Approach - avoidance conflict is a model used in psychology to test how animals deal with regulating fear and anxiety.

Page and his colleagues, who use animal models to understand how autism risk factors impact the developing brain and to identify potential treatments for the condition, have found that animals with mutations in the autism risk gene phosphatase and tensin homolog (Pten) mimic aspects of autism, including increased brain size, social deficits and increased repetitive behavior.

Our study goes a long way towards validating the usefulness of this animal model and provides enormous support for its use in human illnesses.

«We could use these animals as a model to see what happens to heart health if we increase the omega - 3 levels in the body.»

Using a new technique to deliver gene - therapy - like intervention directly where it's needed, researchers at Thomas Jefferson University successfully increased or decreased the muscle tone of the anal sphincter in appropriate animal models.

The scientists tested the new compound using a mouse model of TB and found that substituting R207910 for one of three antibiotics in a treatment cocktail significantly reduced the time required to clear the animals» lungs of bacteria.

«We know that urate has neuroprotective properties in animal models, and an unusual convergence of human studies suggested its possible use as a disease - modifying strategy in Parkinson's; so the positive results of this trial are very encouraging.»

In this study, the Hiroshima University researchers developed an animal model using severely immunodeficient mice whose livers were partially populated with human cells, in order to reconstruct elements of the human immune systeIn this study, the Hiroshima University researchers developed an animal model using severely immunodeficient mice whose livers were partially populated with human cells, in order to reconstruct elements of the human immune systein order to reconstruct elements of the human immune system.

Using animal models of precancerous polyps in the bowel, Chung and his team determined that certain types of immune cells within a chronically inflamed intestine can become rewired, causing them — paradoxically — to contribute to disease development rather than protect against it.

While mouse models have traditionally been used in studying the genetic disorder, Deng said the animal model is inadequate because the human brain is more complicated, and much of that complexity arises from astroglia cells, the star - shaped cells that play an important role in the physical structure of the brain as well as in the transmission of nerve impulses.

The brochures contain information about toxicology, pharmacology, and animal safety studies used to determine the potential risk a particular therapy may pose to humans, but they also include efficacy studies done in animal models to demonstrate a therapy's potential benefit.

In the new study, Professor Pisani and colleagues used cutting edge statistical techniques (Posterior Predictive Analyses) to test whether the evolutionary models routinely used in phylogenetics can adequately describe the genomic datasets used to study early animal evolutioIn the new study, Professor Pisani and colleagues used cutting edge statistical techniques (Posterior Predictive Analyses) to test whether the evolutionary models routinely used in phylogenetics can adequately describe the genomic datasets used to study early animal evolutioin phylogenetics can adequately describe the genomic datasets used to study early animal evolution.

Its research includes a cluster of related interdisciplinary projects that examine disparities in breast cancer mortality between African - American and Caucasian women using animal models, molecular characterization of tumors, and behavioral research focused on social - environmental factors.

Dr. Michael M. Yartsev, Research Associate and C.V. Starr Fellow at the Princeton Neuroscience Institute at Princeton University receives the US$ 25,000 research prize for his work using the bat as an unusual animal model to study the underlying neural mechanisms of spatial memory and navigation in the mammalian brain.

Using electrophysiology and pharmacological tools, the research has shown that a potassium channel, specifically the BK channel, in the central nervous system can be regulated with drugs to increase or decrease these disruptions in animal models.

Scientists have used UV radiation to cause skin cancer in animal models.

Using the model, the researchers demonstrated a significant reduction of HO in animals treated with rapamycin.

«The big question about why we mammals affiliate with one potential partner versus another finally has a handle we can use in a small animal model,» says Lucy Brown at the Albert Einstein College of Medicine in New York.

Why the drug combination works in resistant CML Why such a combination of the two inhibitor types works in an animal model has now been explained by Prof. Stephan Grzesiek's team at the Biozentrum of the University of Basel and Dr. Wolfgang Jahnke from Novartis, by a structural analysis using nuclear magnetic resonance spectroscopy (NMR).

In the new study, the Salk scientists used a mouse model of autism — an inbred strain of mouse previously found to display autism - like symptoms — to ask whether lowering the level of dicarbonyl methylglyoxal (a common byproduct of sugar metabolism) could alleviate symptoms of autism in the animalIn the new study, the Salk scientists used a mouse model of autism — an inbred strain of mouse previously found to display autism - like symptoms — to ask whether lowering the level of dicarbonyl methylglyoxal (a common byproduct of sugar metabolism) could alleviate symptoms of autism in the animalin the animals.

The researchers hope these findings will aid in developing new treatments by using animal models that more closely represent the types of mutations apparent in the vast majority of patients with enchrondromas.

To better determine the role of specific chemoattractants in type III hypersensitivity, lead author Yoshishige Miyabe, MD, PhD, a research fellow in Luster's lab, used multiphoton intravital microscopy — an imaging technology pioneered for studies of immune cell movements in living animals by CIID investigator and co-author Thorsten Mempel, MD, PhD — to follow in real time the development of IC - induced arthritis in a mouse model of rheumatoid arthritis.

Using a novel approach for imaging the movement of immune cells in living animals, researchers from the Massachusetts General Hospital (MGH) Center for Immunology and Inflammatory Diseases (CIID) have identified what appear to be the initial steps leading to joint inflammation in a model of inflammatory arthritis.

He sees the capability of using the team's research in the future to design models that will help game managers, conservation managers, farmers and tour operators predict animal migration, whether it's zebras or other migratory animals.

Now, the researchers have discovered an alternative in a mouse model: in the case of breast tumours with a specific defect in DNA repair, the animals can be cured using already established, cheap chemotherapy drugs, if enough DNA damage can be inflicted on the resting tumour cells.

An earlier study used reversible lesions in the BNST and CeA to block the function in these two areas and then examined their effects in a unique animal model of cocaine self - administration.

Most animal studies of the disease are conducted with laboratory mice that have been genetically engineered and bred to model ALS, but for this research, investigators used rats with ALS because they more accurately portray the disease's variable course in humans.

«We have demonstrated for the first time in an animal model that maternal use of a class of antidepressants called selective serotonin reuptake inhibitors, or SSRIs, resulted in increased fat accumulation and inflammation in the liver of the adult offspring, raising new concerns about the long - term metabolic complications in children born to women who take SSRI antidepressants during pregnancy,» says PhD student Nicole De Long, who presented this research on June 22nd at the joint meeting of the International Society of Endocrinology and The Endocrine Society.

«With further development, the new microendoscope could be used to image neuron activity in previously inaccessible parts of the brain such as the visual cortex of primate animal models,» said Ohayon.

In recent years, songbirds» similarities to human vocal learning have piqued researchers» interests in using them as a functional animal model to study the neurological basis for Huntington's diseasIn recent years, songbirds» similarities to human vocal learning have piqued researchers» interests in using them as a functional animal model to study the neurological basis for Huntington's diseasin using them as a functional animal model to study the neurological basis for Huntington's disease.

In all, the researchers used a set of mathematical models to reveal that today animals only have about 6 % of their former capacity to move such nutrients away from «hot spots» and across the oceans and land.

Australian researchers used computerized tomography scans of the head of a great white shark accidentally killed in a commercial fishing net (great whites are a protected species) to construct a model of the animal's jaw musculature.

The National Institutes of Health had agreed to fund the study, which involved creating an animal model of anthrax infection in baboons, and the university's animal use and care committee had given it the green light.

Pickles and Liesman then used their reengineered PIV expressing RSV NS2 in animal models to provide more clinical relevance for their findings.