One potential reason for this discrepancy is that the laboratory tests
used in animal models of the disease do not resemble the clinical assessments given to patients, and thus are not predictive of human memory performance.
Not exact matches
These findings allowed researchers to create a chimera virus: a mouse virus with a human viral gene that can be
used to test molecules that inhibit human LANA protein
in an
animal model of disease, treating not only human herpes virus infection but also its associated cancers.
«We know that urate has neuroprotective properties
in animal models, and an unusual convergence
of human studies suggested its possible
use as a
disease - modifying strategy
in Parkinson's; so the positive results
of this trial are very encouraging.»
Using animal models of precancerous polyps
in the bowel, Chung and his team determined that certain types
of immune cells within a chronically inflamed intestine can become rewired, causing them — paradoxically — to contribute to
disease development rather than protect against it.
Most
animal studies
of the
disease are conducted with laboratory mice that have been genetically engineered and bred to
model ALS, but for this research, investigators
used rats with ALS because they more accurately portray the
disease's variable course
in humans.
In a further step, the researchers used mathematical models to predict how an infectious disease would spread considering the changes in behaviour of the sick animal
In a further step, the researchers
used mathematical
models to predict how an infectious
disease would spread considering the changes
in behaviour of the sick animal
in behaviour
of the sick
animals.
In a novel animal study design that mimicked human clinical trials, researchers at University of California, San Diego School of Medicine report that long - term treatment using a small molecule drug that reduces activity of the brain's stress circuitry significantly reduces Alzheimer's disease (AD) neuropathology and prevents onset of cognitive impairment in a mouse model of the neurodegenerative conditio
In a novel
animal study design that mimicked human clinical trials, researchers at University
of California, San Diego School
of Medicine report that long - term treatment
using a small molecule drug that reduces activity
of the brain's stress circuitry significantly reduces Alzheimer's
disease (AD) neuropathology and prevents onset
of cognitive impairment
in a mouse model of the neurodegenerative conditio
in a mouse
model of the neurodegenerative condition.
Such ease
of use will likely encourage the use of more animal models in the study of human diseases, says Rhonda Wiler, a geneticist at biotech giant Genentech in San Francisco, California, who co-chairs the Roundtable on Science and Welfare in Laboratory Animal Use (which organized the worksho
use will likely encourage the
use of more animal models in the study of human diseases, says Rhonda Wiler, a geneticist at biotech giant Genentech in San Francisco, California, who co-chairs the Roundtable on Science and Welfare in Laboratory Animal Use (which organized the worksho
use of more
animal models in the study of human diseases, says Rhonda Wiler, a geneticist at biotech giant Genentech in San Francisco, California, who co-chairs the Roundtable on Science and Welfare in Laboratory Animal Use (which organized the work
animal models in the study
of human
diseases, says Rhonda Wiler, a geneticist at biotech giant Genentech
in San Francisco, California, who co-chairs the Roundtable on Science and Welfare
in Laboratory
Animal Use (which organized the work
Animal Use (which organized the worksho
Use (which organized the workshop).
Experimental
animal models have been
used to investigate many aspects
of the clinical
disease such as the sex bias
in myocarditis where testosterones
in males promote autoimmunity
in the heart while estrogens
in females suppress virus infection and autoimmunity.
This
animal model closely resembles lesion kinetics as seen
in human
disease [34] and
use of non-human primates allows for repetitive surgical sampling for multiple time point analysis.
Katherine W. Klinger, PhD, Senior Vice President for Genetics and Genomics at the Genzyme Corporation, and Assistant Clinical Professor
in the Department
of Pediatrics at the University
of Connecticut School
of Medicine suggested that for an orphan
disease it may be necessary to
use multiple
animal models in the preclinical research stage, because one
animal model may not fully recapitulate the human
disease.
It is also intended for post-docs and scientists already working
in certain
of these fields and who are interested
in expanding their knowledge on the potential applications
of these new techniques to their
models or
in neighbouring pathophysiological
models of analysis
of genes or
diseases using genetically modified
animals.
In animal models of disease, iPSCs have been
used to treat sickle cell anemia, Parkinson's
disease, diabetes, spinal cord injuries, and heart failure.
Fallon said that
in addition to the value
of the findings themselves, the study demonstrates advances
in creating
animal models that can be
used more successfully
in mimicking the
disease in ALS research, which is a key element
in driving new research and possible therapies.
At BPRC non-human primate (NHP)
models of infectious
diseases are available
in high quality,
using purpose - bred and MHC - typed
animals.
He also showed that DBSI could be
used to examine the development
of white matter inflammation
in patients with neurodegenerative
diseases and
in animal models of these
diseases.
Because
of the pivotal role that diet plays
in causing the MS
in humans, most metabolic
disease animal models do (and we believe should)
use diet as a way to precipitate this syndrome.
In addition, the Fletcher group investigates immunity using the mouse model and aims to develop animal models of TB disease better able to predict TB vaccine efficacy in clinical trial
In addition, the Fletcher group investigates immunity
using the mouse
model and aims to develop
animal models of TB
disease better able to predict TB vaccine efficacy
in clinical trial
in clinical trials.
Examples
of studies conducted with assistance
of the Center are pre-clinical studies
of orthopedic devices intended for
animal and human
use, clinical studies
of treatment and prevention
of respiratory
diseases in horses and
animal clinical trials evaluating the treatment
of bladder cancer
in Scottish Terriers, an
animal model of human bladder cancer.