Sentences with phrase «used in clinical trials as»

Not exact matches

In fact, one of Marathon's clinical trials that the FDA used as part of its decision - making process was conducted more than 20 years ago, saving the firm plenty of study costs.

(Culver City, CA August 27, 2013)-- After Oryzatein ® was recognized as the first plant - based rice protein to equal animal - based whey protein for muscle building and repair in a clinical trial published last month, an «Oryzatein ® Inside» endicia is being provided to manufacturers who use the ingredient in their food products.

Throughout 2017, ongoing clinical trials in regenerative medicine using cord blood have offered hope to families facing life - changing medical conditions, such as cerebral palsy and autism.1 For some of these families, banking their baby's cord blood with ViaCord gave them the opportunity to participate in this groundbreaking research.

In addition, there was no effect on breastfeeding duration when the pacifier was introduced at 1 month of age.280 A more recent systematic review found that the highest level of evidence (ie, from clinical trials) does not support an adverse relationship between pacifier use and breastfeeding duration or exclusivity.281 The association between shortened duration of breastfeeding and pacifier use in observational studies likely reflects a number of complex factors such as breastfeeding difficulties or intent to wean.281 A large multicenter, randomized controlled trial of 1021 mothers who were highly motivated to breastfeed were assigned to 2 groups: mothers advised to offer a pacifier after 15 days and mothers advised not to offer a pacifieIn addition, there was no effect on breastfeeding duration when the pacifier was introduced at 1 month of age.280 A more recent systematic review found that the highest level of evidence (ie, from clinical trials) does not support an adverse relationship between pacifier use and breastfeeding duration or exclusivity.281 The association between shortened duration of breastfeeding and pacifier use in observational studies likely reflects a number of complex factors such as breastfeeding difficulties or intent to wean.281 A large multicenter, randomized controlled trial of 1021 mothers who were highly motivated to breastfeed were assigned to 2 groups: mothers advised to offer a pacifier after 15 days and mothers advised not to offer a pacifiein observational studies likely reflects a number of complex factors such as breastfeeding difficulties or intent to wean.281 A large multicenter, randomized controlled trial of 1021 mothers who were highly motivated to breastfeed were assigned to 2 groups: mothers advised to offer a pacifier after 15 days and mothers advised not to offer a pacifier.

The safety of the vaccine has been established in large clinical trials and will be continually monitored as it comes into wider use,» Ed Yong, health information manager at the charity told politics.co.uk

«Thus, we hope that its potential as a powerful therapeutic agent for the treatment of autoimmune diseases will facilitate its use in future clinical trials.»

«If you don't use as close to the total physiological system that you can, you're likely to run into troubles,» like being surprised by side effects later on in clinical trials, says William Haseltine, founder and former chairman and CEO of Rockville, Md. — based Human Genome Sciences.

The results, published online in the journal Brain, Behavior and Immunity, strengthen the case that transgenic Huntington's disease monkeys could be used to evaluate emerging treatments (such as this) before launching human clinical trials.

Two of the drugs are investigational and approved by the Food and Drug Administration (FDA) for use in people as part of clinical trials; the third drug is FDA - approved to treat rheumatoid arthritis.

«If we find that lymphoscintigrams using tilmanocept are at least as good as the conventional radiocolloid tracer in identification and visualization of sentinel nodes, we would like to see a randomised clinical trial involving large numbers of patients,» says Prof de Bree.

As Scientific American reported earlier this year, more than half of the current cancer clinical trials do incorporate some form of immunotherapy but still oncologists are often only in the early stages of understanding how to use such treatment on a larger scale.

People working in biomanufacturing need to be prepared for inspections by the US Food and Drug Administration and the European Medical Evaluation Agency designed to ensure that mass - produced proteins are of the same quality as those used in clinical trials.

The researchers reprogrammed the cells to create induced pluripotent stem cells in an FDA - compliant facility at the Broad Stem Cell Research Center; the use of this facility is an important step in the process as preclinical research moves toward human clinical trials.

Although most of the shortages affect old, generic drugs, clinical trials often use these staples, either as controls or in combination with experimental medicines, including the genetically targeted drugs that many hope will revolutionize cancer care.

The 207 patients enrolled in the clinical trial, known as POSITRON, either did not respond to interferon, could not tolerate it or were unwilling to use it, despite the fact that there were no other treatment options available to them.

The researchers tested two anti-CK2 drugs for their ability to stimulate the production of new brown fat in mice: a new small - molecule CK2 - blocker called silmitasertib (CX - 4945), which is already in clinical trials as a cancer therapeutic; and a more precise next - generation antisense oligonucleotide (ASO) drug developed in collaboration with Isis Pharmaceuticals, which eliminates CK2 by blocking the RNA instructions cells use to produce it.

Osaka University scientists found that some potential γ — secretase inhibitors such as semagacestat, which have been used in large clinical trials that ended in failure, do not function as true inhibitors as originally expected, but rather cause accumulation of toxic intraneuronal Aβ.

In the findings, the researchers point to the use of intensive behavioral counseling in combination with pharmaceutical aids as a factor that may have contributed to an increase in smoking cessation rates during clinical trialIn the findings, the researchers point to the use of intensive behavioral counseling in combination with pharmaceutical aids as a factor that may have contributed to an increase in smoking cessation rates during clinical trialin combination with pharmaceutical aids as a factor that may have contributed to an increase in smoking cessation rates during clinical trialin smoking cessation rates during clinical trials.

In a particularly dramatic demonstration at the Stanford site of the pilot clinical trial, a woman identified as «T6,» who is diagnosed with amyotrophic lateral sclerosis, was able to use BrainGate for six sessions of a few hours each over the course of 42 days without any interruptions for explicit recalibration after the decoder was initialized on the first day.

And up to half of participants enrolled in clinical trials to treat PTSD fail to respond to therapies including serotonin - reuptake inhibitors — a class of drugs often used as antidepressants — and cognitive behavioural therapy.

The study, published in the July issue of the journal Epidemiology, offers benefits over typically used randomized clinical trials, as such studies are often too small to identify rare side effects or may be performed in a group of patients who do not take other types of medications or have other conditions that could skew the drug's effect in a broader group following approval.

«Given the continued high prevalence of multivitamin use in the US, it remains critical for us to understand its role on nutritional status and other long - term health outcomes through clinical trials such as PHS II and other new research initiatives.»

The U.K. government also noted that «affected African countries will have the primary role of authorising or allowing use of investigational vaccines» and said «buy in» from those communities about the clinical trials must be obtained as soon as possible.

The careful choice of the pig model as well as use of readily available microbubbles and ultrasound was instrumental in studies moving to clinical trials.

«As a basic scientist, it is exciting to be able to translate a laboratory discovery into drugs that are now being used in a clinical trial.»

«Many clinical trials in pulmonary hypertension also use the catheter test as an outcome measure, but it could provide a significant advantage to be able to replace it with a less invasive MRI scan, as our model also provides more detailed information on physical changes to the heart itself.»

«RNAi therapies are a unique approach to cancer treatment as they have the potential to «turn off» the genes» coding for proteins involved in cancer cell division,» said Ramesh K. Ramanathan, M.D., medical director of the Virginia G. Piper Cancer Center Clinical Trials Program at Scottsdale Healthcare and deputy director of the Clinical Translational Research Division of the Translational Genomics Research Institute (TGen) in Phoenix, Ariz. «Using a lipid nanoparticle, the RNAi drug can be delivered to a cancer cell to block the expression of specific proteins involved in tumor growth.»

Among the 60 compounds, they found one that previously had been used as an antibiotic and is now in clinical trials for Alzheimer's disease.

Using the large patient group in the ProTECT III trial, the researchers hope to validate promising TBI biomarkers as predictors of clinical outcome and also evaluate the relationship between progesterone treatment, biomarker levels and outcome.

These results could pave the way for the use of progesterone against glioblastoma in a human clinical trial, perhaps in combination with standard - of - care therapeutic agents such as temozolomide.

«Lithium, long used in mental health as a highly effective mood stabiliser, has been on the radar as a potential disease modifying treatment for Alzheimer's disease with positive evidence from preclinical studies and a number of small clinical trials.

The GDC will support clinical trials that focus on single patients, known as «n of 1» clinical trials, and will become an important component in how precision medicine is used to treat individual patients.

This paper provides direct evidence for the role of TNF in chronic intestinal inflammation using TNBS colitis in Tg197 mice as a model and encourages further clinical trials with anti-TNF therapeutics for the treatment of Crohn's disease.

As we'll see later on, this has already contributed to their receiving FDA - approval for use in a clinical trial.

The SICI - ICF / SAI measure has been shown to provide the footprints of the specific underlying neurotransmitter deficit, having the potential to be used as an additional diagnostic instrument in clinical practice and eventually in clinical trials.

But, he notes that it will be necessary to perform well - designed clinical trials that test the safety and efficacy of high - grade NMN in humans before making the leap to using NMN (or perhaps its analogs) as pharmacotherapeutic agents.

In this role, Ms. Roxland re-launched and chaired J&J's Ethics Committee, created an enterprise - wide consultation service for teams and individuals confronting complex research ethics issues, and provided guidance on issues such as post-trial access for former research participants, conducting clinical trials in war - torn regions, testing of a potential Ebola vaccine during a public health crisis, commercialization of stem cell therapies, subject recruitment and withdrawal, and expanded access / compassionate usIn this role, Ms. Roxland re-launched and chaired J&J's Ethics Committee, created an enterprise - wide consultation service for teams and individuals confronting complex research ethics issues, and provided guidance on issues such as post-trial access for former research participants, conducting clinical trials in war - torn regions, testing of a potential Ebola vaccine during a public health crisis, commercialization of stem cell therapies, subject recruitment and withdrawal, and expanded access / compassionate usin war - torn regions, testing of a potential Ebola vaccine during a public health crisis, commercialization of stem cell therapies, subject recruitment and withdrawal, and expanded access / compassionate use.

Applications involving contracts (such as used for large, multicenter clinical trials) were not included in these analyses.

However, with few exceptions, the stem cell and regenerative medicine industry has remained inadequately capitalized to carry out large - scale clinical trials independently, and major pharmaceutical firms have tended to show more interest in the use of hiPSCs as a source of large, pure populations of specific somatic cells for use in drug compound screening and toxicology tests, than they have in therapeutic uses of stem cells and their derivatives.

Objective: The primary objective of the present study was to estimate how large a sample size would be needed for future clinical trials for AD - modifying treatments in Japan using atrophy measures of the brain as a surrogate biomarker.

Conclusion: These results show the potential use of longitudinal hippocampal atrophy measurement using automated image analysis as a progression biomarker and ApoE status as a trial enrichment strategy in a clinical trial of AD - modifying treatment in Japanese people.

They examined two inhibitors, one known as avibactam that is already being used in clinical trials, and another that is a bicyclic boronate inhibitor.

As Head of Project Leader Unit, Nicolas is in charge of the pharmaceutical development and subsequent production of vaccines - for use in clinical trials - directly funded by the European Vaccine Initiative (EVI), and European projects funded from other sources coordinated by EVI.

Finally, analysis of tumors from clinical trials and cell line models will allow discovery of mechanisms of sensitivity and resistance to AR and PI3K inhibitors, as well as biomarkers that can be used in the development of new treatment regimens and selection of patients for future trials.

«We are very excited about using VSV as researchers have seen promising results using other similar viruses, such as the polio virus, in early clinical trials.»

However, ADCs that use derivatives of calicheamicin, which promotes double - stranded DNA breaks, such as GO and inotuzumab ozogamicin, 40,41 have limited activity in cells with high multidrug resistance protein activity, a phenotype found in a significant fraction of AML patients.42 Another ADC, SGN - CD123A, comprising an engineered form of the CD123 - targeting 7G3 antibody conjugated to a synthetic pyrrolobenzodiazepine dimer, which acts via DNA crosslinking, has entered clinical trials after showing robust activity in preclinical models of AML, including those with multidrug resistance.33

Peppermint extract or oil, used commonly in baking, doubles as a reliable headache cure — one backed by several small clinical trials and lots of anecdotal evidence.

Information such as dosage, serving size and, in many cases, suggested use are based on the doses used in actual clinical trials.

The typical dosage of NAC given as an oral supplement in clinical trials is 600 mg b.i.d., although 200 mg t.i.d. has been shown to provide benefit in just 8 weeks.27 On the other hand, doses as high as 1 gram t.i.d. have been used in cystic fibrosis patients for 4 - 12 weeks with no adverse effects, and in AIDs patients, oral NAC doses up to 8 grams / day did not cause clinically significant adverse reactions.42 43 44 45 46 47

Whereas the few randomized controlled trials and observational clinical outcomes studies support the existence of a health benefit from fasting, substantial further research in humans is needed before the use of fasting as a health intervention can be recommended.