Sentences with phrase «used in embryonic development»

Study shows memories formed by the same gene - silencing tool used in embryonic development; a finding could set the stage for new therapies for schizophrenia

Not exact matches

When cloning is successful, the adult nucleus is stripped of its epigenetic programming, and is restored to a totipotent state that can use all the genetic information present in the nucleus to orchestrate the complete program of embryonic development.

As specialized cells are generated during embryonic development, they are programmed to use only a limited amount of the total genetic information present in the nucleus to produce the proteins required for their particular function.

The idea of development seems to have come from biology, where it is used in reference to the process of evolution from a previous and lower (e.g., embryonic) stage to a later, more complex or more perfect one; this development can involve differentiation into individual organisms and their subsequent histories.

From such work, we've learned that many of the genes deployed in the developing phallus are also used to build limbs during embryonic development.

To investigate whether maternally supplied gdf3 mRNA also plays a role in left - right patterning, the researchers used a series of experimental tricks to supply embryos with enough Gdf3 protein to form the mesoderm and endoderm and survive until the later stages of embryonic development.

The laboratory process, described in the journal Scientific Reports, entails genetically modifying a line of human embryonic stem cells to become fluorescent upon their differentiation to retinal ganglion cells, and then using that cell line for development of new differentiation methods and characterization of the resulting cells.

«In addition to advancing our understanding of human embryonic development, the findings suggest we may be able to use metabolites, relatively simple compounds, to alter cell fate in the treatment of common disorders.&raquIn addition to advancing our understanding of human embryonic development, the findings suggest we may be able to use metabolites, relatively simple compounds, to alter cell fate in the treatment of common disorders.&raquin the treatment of common disorders.»

Using a nuclear protein expressed in follicle stem cells (FSCs), the researchers found that castor, which plays an important role in specifying which types of brain cells are produced during embryonic development, also helps maintain FSCs throughout the life of the animal.

In the meantime, Boeke says Sleeping Beauty could provide a new and better way to create mutants to study embryonic development, since the inactivated gene can be «tagged» using a short DNA sequence inserted by the transposon.

Because development often reprises stages of evolution, the growth of embryonic ears in tandem with the jaw is no accident: the sound - transmitting middle ear bones that are a distinguishing feature of mammals evolved from what used to be gill arches in fish and jawbones in reptiles.

The only previous trial using ES cells to treat Parkinson's began last year in Australia; participants there received stem cells from parthenogenetic embryos — unfertilized eggs that are triggered in the lab to start embryonic development.

Scientists use OCT4 protein to reprogram adult cells into embryonic - like cells, an indication that it is involved in early development (SN: 11/24/07, p. 323).

Comparison of the data revealed that use of certain starting points differs in two phases of embryonic development in particular: Before and after activation of the embryonic genome.

Using the CAGE (Cap Analysis of Gene Expression) high - throughput method, the scientists determined the starting points of transcription of many thousands of genes in various phases of embryonic development of zebrafish.

Because the RNAi wasn't used to dampen FOXP2 activity until 23 days after the birds hatched, the new study shows that the gene has a role beyond embryonic development, says neurogeneticist Simon Fisher of the University of Oxford in the U.K. «The gene, at least in songbirds, may have important active functions in [neural] circuits,» he says.

Other potential uses of embryonic stem cells include investigation of early human development, study of genetic disease and as in vitro systems for toxicology testing.

The researchers used this live - imaging technique to study fly embryos at a key stage in their development, approximately two hours after the onset of embryonic life where the genes undergo fast and furious transcription for about one hour.

Birds have been the model organisms for studying embryonic development for many years, but the difficulty in applying transgenesis to birds has hampered the use of the avian model in modern science.

Corey Nislow's laboratory develops and uses cutting edge tools to address this central question: how can we understand the biological commonalities in all of the life sciences; from embryonic development, to the spread of infectious diseases to better ways to treat cancer.

Correspondingly, endothelial - specific deletion of Tie2 using Ve - cad - Cre driver mice, pursued in validating the Tie2fl / fl mice used in this study, essentially phenocopied the global Tie2 KO phenotype with embryonic lethality around E10.5 (Supplementary Fig. 13), confirming the key role of endothelial Tie2 during embryonic development.

seek to identify the mutational processes underlying mutational signatures found in cancers, characterise the mutational processes operating in normal cells, use phylogenetic analyses of somatic mutations in humans to explore cellular lineages during embryonic development

In addition, we use our expertise to facilitate the development of functionally mature beta cells from embryonic stem cells for cell replacement therapies of type 1 diabetes.

During embryonic development, cells use the information contained in their genome to build the organism.

RT - PCR analysis of RNA from mouse embryonic and adult gonads using primers corresponding to either exons 3 and 9 (upper panel, 501 - bp band) or exons 3 and 12 (lower panel, 847 - bp and 712 - bp bands) reveals that full - length Bol1 is only expressed in postnatal testes, while Bol2 lacking exon 11 is also detectable at low levels throughout gonadal development in addition to its high adult testis expression.