Not exact matches
Using animal models of
precancerous polyps in the bowel, Chung and his team determined that certain types of immune
cells within a chronically inflamed intestine can become rewired, causing them — paradoxically — to contribute to disease development rather than protect against it.
But, counter-intuitively, this mass
cell death might be the very thing that makes the animals so long - lived: it could be a natural mechanism their bodies
use to clear
precancerous cells, stopping tumors in their tracks.
Two types of vaccines were
used for the study: one constructed with genetically engineered DNA molecules that teach immune system
cells to recognize premalignant
cells expressing HPV16 E7 proteins, and one that is a non-infectious, engineered virus that targets and kills
precancerous cells marked by HPV16 and HPV18 E6 and E7 proteins.