Sentences with phrase «used preclinical models»

This proof - of - concept study used preclinical models to demonstrate that the device was effective in reducing the cancerous tumour in the living brain.

«Using our preclinical model, we will determine what existing chemotherapies can be combined with this novel drug type to produce the best therapeutic effects,» he said.

Using a preclinical model of breast cancer, the researchers showed that anti-tumor cells placed via scaffold prevented relapse while intravenously administered T cells did not.

Not exact matches

In preclinical studies using cell models that mimicked liver cells of patients with the rare disease Friedreich's ataxia (FA), a widely used cholesterol - lowering drug increased a precursor of HDL (high - density lipoprotein), the «good cholesterol,» according to new research published in PLOS ONE from the Perelman School of Medicine at the University of Pennsylvania.

Furthermore, the team found that ONA inhibited the pro-tumor functions of myeloid derived suppressor cells (MDSC), which are closely associated with the suppression of the anti-tumor immune response of host lymphocytes, by using preclinical sarcoma model.

Developing therapies and testing drugs using current preclinical models have limitations in reliability and predictability.

Currently, Deng's laboratory is conducting additional preclinical studies using the human - derived stem cells from Down syndrome patients and mouse models to determine whether cellular and behavioral abnormalities can be improved with minocycline therapy and other candidate drugs.

Before PCSK9 inhibitors can be approved for widespread use, further research into PCSK9 function using suitable preclinical models is needed.

«The novelty of this study is two-fold: We used a preclinical prevention paradigm of a CRF - antagonist (a drug that blocks the CRF receptor in brain cells) called R121919 in a well - established AD model — and we did so in a way that draws upon our experience in human trials.

In a paper published in Advanced Functional Materials, the research team reports on the new material's key properties, many of which can be finely tuned, and on the results of using the material in preclinical models of wound healing.

Using their previously established sporadic PD mouse model, the researchers conducted both prevention and intervention preclinical studies.

The laboratory's Oncology Preclinical Services team, which offers preclinical efficacy studies using PDX and other models, including humanized (hu)- NSG mice, is also under hisPreclinical Services team, which offers preclinical efficacy studies using PDX and other models, including humanized (hu)- NSG mice, is also under hispreclinical efficacy studies using PDX and other models, including humanized (hu)- NSG mice, is also under his direction.

Using all the existing data that was available, Andrechek, along with MSU doctoral student Daniel Hollern, analyzed 1,172 mouse mammary tumor samples from 26 different preclinical models and was able to compile one of the largest databases to show which strains of mice were best suited to study a particular type of human breast cancer.

«We report much higher therapeutic efficacy in preclinical brain tumor models using the combination of both therapies, leading to an increase in median survival,» Lowenstein says.

E. Intensify research on the major drivers of childhood cancers Improve our understanding of fusion oncoproteins in pediatric cancer and use new preclinical models to develop inhibitors that target them.

Katherine W. Klinger, PhD, Senior Vice President for Genetics and Genomics at the Genzyme Corporation, and Assistant Clinical Professor in the Department of Pediatrics at the University of Connecticut School of Medicine suggested that for an orphan disease it may be necessary to use multiple animal models in the preclinical research stage, because one animal model may not fully recapitulate the human disease.

Dr. Pham is presently investigating cell therapy using a transgenic and preclinical mouse model.

Our scientists engage with you in the design and execution of your preclinical drug development program using our AAALAC approved animal facilities, proprietary animal models, and extensive capabilities.

To test the efficacy of J147 in a much more rigorous preclinical AD model, we treated mice using a therapeutic strategy more accurately reflecting the human symptomatic stage.

To test the efficacy of J147 in a much more rigorous preclinical Alzheimer's model, the Salk team treated mice using a therapeutic strategy that they say more accurately reflects the human symptomatic stage of Alzheimer's.

Preclinical studies of the effects on this drug on neurodegeneration have been done but do not appear to have been published so I do not know which disease models were used.

The phenotyping platforms of PHENOMIN - ICS area, adapted to study genetically modified mouse models, can also be used for preclinical studies, including the validation of therapeutic targets, as well as pharmaceutical and toxicological studies in mice.

The preclinical models are also used for trialling novel anti-metastatic agents targeting gene products found to drive metastasis.

Today our rich collection of arthritis mouse models is widely used for the preclinical evaluation of the efficacy of anti-arthritic pharmaceuticals and offer an ideal platform for establishing proof of concept for novel technological advances.

Collagen Antibody Induced Arthritis (CAIA) is a simple mouse model of rheumatoid arthritis that can be used for the fast preclinical efficacy evaluation of candidate therapeutic agents targeting pathogenic mechanisms and inflammatory processes of arthritis.

PHILADELPHIA — In preclinical studies using cell models that mimicked liver cells of patients with the rare disease Friedreich's ataxia (FA), a widely used cholesterol - lowering drug increased a precursor of HDL (high - density lipoprotein), the «good cholesterol,» according to new research published in PLOS One from the Perelman School of Medicine at the University of Pennsylvania.

Biomedcode is a Contract Research Organisation (CRO) providing full preclinical drug evaluation services to the pharmaceutical industry using a unique collection of mouse models of human inflammatory diseases.

Her research involves preclinical immunology and efficacy of vaccines against H5N1 pandemic influenza, malaria, and Mycobacterium tuberculosis using mouse, ferret and guinea pig models.

Biomedcode offers preclinical testing using complex mouse models closely recapitulating the complexity of human disease as they also exhibit co-developing pathologies also observed in human patients.

The lab used MRS in a preclinical study of SAPAP3 knockout mice — which model aspects of human obsessive compulsive and related disorders (OCRD)-- to determine whether these mice exhibit neurochemical abnormalities found in humans with OCRD.

Promising compounds are being generated using established high throughput screening by medicinal chemistry and are being tested in preclinical animal models.

The diverse group of experts has developed a biorepository of patient - derived tissues, which will be used for testing investigational drugs in preclinical models.

The partnership is designed to use Organ - Chips that reflect the complex biology required to model the effects of therapeutic antibodies in humans, overcoming the limitations of current preclinical experimental methods.

Duke s research will use patented multielectrode technology to directly measure the activity of hundreds of neurons to study brain dynamics in unique preclinical models of diseases such as Parkinson s and schizophrenia.

However, ADCs that use derivatives of calicheamicin, which promotes double - stranded DNA breaks, such as GO and inotuzumab ozogamicin, 40,41 have limited activity in cells with high multidrug resistance protein activity, a phenotype found in a significant fraction of AML patients.42 Another ADC, SGN - CD123A, comprising an engineered form of the CD123 - targeting 7G3 antibody conjugated to a synthetic pyrrolobenzodiazepine dimer, which acts via DNA crosslinking, has entered clinical trials after showing robust activity in preclinical models of AML, including those with multidrug resistance.33

Over 170 carefully curated, well - characterized patient - derived xenograft tumor models are available for use in your facility, or use Horizon's comprehensive preclinical in vivo efficacy service.