Sentences with phrase «used small molecule inhibitors»

To this end, we made use of two widely used small molecule inhibitors, PD98059 and SB203580.

Probing the catalytic functions of Bub1 kinase using the small molecule inhibitors BAY - 320 and BAY - 524.

Not exact matches

Using small - molecule inhibitors to eliminate the activity of the proteins produced by the bird - specific, median signaling zone in chicken embryos, the researchers were able to induce the ancestral molecular activity and the ancestral anatomy.

Our team is currently developing methods that can be used to screen small molecule inhibitors of EDD1 and also looking into how the regulation of TIP60 levels can be translated into therapeutic advances for the treatment of viral - mediated cancers such as cervical cancer.

By using pharmacological small molecule inhibitors as well as neutrophils from genetically modified mouse strains the team could identify essential receptor and signaling pathways involved in the nicotine - mediated activation of neutrophils.

By using a small molecule called 2 - bromo - palmitate (2BP) that inhibits these palmitate - adding enzymes, the researchers surmise that cancer patients might be able to one day make their cells more sensitive to cancer - fighting EGFR inhibitors.

«If we could design a small molecule inhibitor that would look like heme - iron but would actually clog up a key metabolic pathway in bacteria, we may be able to get around the problem of antibiotic resistance,» suggests Dr. Mason, who adds that he and Dr. Justice plan to use the new five - year NIH grant to further studies of just such an inhibitor.

Use of dynasore, the small molecule inhibitor of dynamin, in the regulation of endocytosis.

We have used a variety of cell models to test toxicity, cell penetration, and efficacy of furin inhibitors, and have identified small molecule inhibitors selective for cell surface furin action as well as inhibitors which also work intracellularly.

Bae N, Viviano M, Su X, Lv J, Cheng D, Sagum C, Castellano S, Bai X, Johnson C, Khalil MI, Shen J, Chen K, Li H, Sbardella G, Bedford MT. (2017) Developing Spindlin1 small - molecule inhibitors by using protein microarrays.

Using Chemotype Evolution, Carmot has identified potent small molecule and peptide - small molecule hybrid inhibitors.

Evaluating the efficacy of repurposed small molecule inhibitors in treating filariasis using preclinical and clinical studies

More recently, the team published the structure of Eis in complex with two potent inhibitors they'd discovered using high - throughput screening of approximately 123,000 small molecules.