Sentences with phrase «used tumor tissue»

The researchers used tumor tissue samples from melanoma patients to search for variations in their internal messaging.

To conduct their study, Kaur, Baiocchi and their colleagues used tumor tissue from patients, cell lines and an animal model.

Not exact matches

Unlike conventional chemotherapies and radiation that indiscriminately eradicate fast - growing tissues and ravage people's bodies with side effects, new therapies specifically target tumors using tailored cells from individual patients.

Also limiting the use of therapeutic stem cells to date, self - renewal, a quality so vital to a fast - growing fetus, can also be a source of cancer risk when haphazard, unlimited cell multiplication results in the abnormal tissue growth seen in tumors.

Researchers used tissue and blood samples to show that the gammopathy (a precursor to myeloma) in both mice and patients with Gaucher disease is triggered by specific lipids, and that the antibodies made by tumor cells in nearly a third of myeloma patients are directed against such lipids.

If the disease requires treatment and isn't widespread, he will use focal brachytherapy — implanted radioactive seeds — to irradiate only the tumor, sparing the surrounding tissue.

Biology professor David Soll and his team used unique computer - assisted 3 - D reconstruction software to chronicle how both breast tissue cancer cells and melanoma cells form tumors.

BPTES has been used in animal models for a variety of cancers but has not substantially reduced tumor sizes, probably because the drug concentration in tumor tissue is not high enough when using conventional drug formulation methods, say the scientists.

Researchers are already using single - cell analysis to identify genetic variations within tumors and tissues, and Langsdorff says the technique is quickly establishing a foothold in microbiology as well.

Plasma samples of patients with NSCLC is a less invasive method and has been used as surrogate tumor tissues for detecting genetic alterations.

If they can be used in living tissue, they might eventually track cells in developing embryos, the immune system, or cancerous tumors.

With mammography, radiologists use x-rays to spot the dense tissue and tiny calcium deposits in breast tumors.

Together they are being used to peer into the microenvironment of tumors and other tissues while learning about the co-registration of multiple lines of imaging data.

High intensity, focused ultrasound can damage tissue by heating and cavitation, and has been used to ablate tumors and other lesions.

To overcome these problems, Min and his team developed a new modality to visualize glucose uptake activity inside single cells based on stimulated Raman scattering (SRS) imaging, and demonstrated its use in live cancer cells, tumor xenograft tissues, primary neurons and mouse brain tissues.

The advantage of proton therapy is that there may be a procedure I could undergo in the future that uses targeted radiation to target the tumorous tissue and that could potentially kill off my tumor.

A software program was used to characterize the breast cancer tumors and detect boundaries between healthy and cancerous tissue.

Doctors already test breast tumors for Ki67 levels, which can inform decisions about treatment, but this is the first time scientists have been able to link Ki67 to precancerous tissue and use it as a predictive tool.

In a bid to progress beyond the shotgun approach to fighting cancer — blasting malignant cells with toxic chemicals or radiation, which kills surrounding healthy cells in the process — researchers at the Harvard - MIT Division of Health Sciences and Technology (HST) are using nanotechnology to develop seek - and - destroy models to zero in on and dismantle tumors without damaging nearby normal tissue.

In medicine, a surgeon might be able to perform remote operations beyond the simple use of a scalpel, or train for tumor screening by feeling for virtual lumps in real tissue.

«As there are no published guidelines for the use of ctDNA for EGFR mutation analysis in the absence of tumor tissue, these results may help address this current unmet need.»

Analysis of images showed that the contrast used by the research team bound almost exclusively to the fibrin - fibronectin complexes, producing a strong and prolonged image enhancement of micrometastases and tumors compared with normal tissue.

One of the candidates for this elastography, a variant of echography whereby the difference in the rigidity of the tumor and healthy tissue can be used to detect cancer.

Previous cancer studies had shown that by injecting tumors with magnetic nanoparticles made of iron oxide — «essentially rust, with well - tuned magnetic properties,» Anikeeva says — then exposing them to rapidly alternating magnetic fields, excited nanoparticles can be used to heat and destroy cancer tumors while leaving surrounding, healthy tissue intact.

Gartner's group plans to use the technique to investigate what cellular or structural changes in mammary glands can lead to the breakdown of tissue architecture associated with tumors that metastasize, invading other parts of the body and threatening the life of the patient.

Investigators compared DNA from the liquid blood biopsies to DNA tissue samples from the tumor, using mate - pair sequencing — an inexpensive whole exome sequencing that can reveal genetic changes that contribute to tumor growth.

This may allow surgeons to look at the perimeter of a growing tumor and use the shape to guide their assessment of which regions could be more problematic — where they need to take out more tissue around the tumor and where they may not need to take as much.»

Reactivation of HBV may occur with chemotherapy, organ and tissue transplantation, High dose corticosteroids, and biologicals targeting tumor necrosis factor - alpha (TNF - α), Anti-TNF medications are used in treating rheumatic diseases, such as rheumatoid arthritis, digestive conditions that include Crohn's and colitis, and dermatologic conditions, such as psoriasis.

Rather than simply identifying a cancer by location or tissue type, researchers now use advanced molecular profiling tests to characterize tumors, the proteins they express and the novel mutations they develop — known as neoantigens.

Using a very sensitive DNA analysis technique that can also be employed when only very small amounts of DNA from old tissue are available, the researchers could compare the two current cell lines with the tumor from which the cell line was established.

Various genetic testing methods were used to examine lung tumors, uninvolved lung tissue and normal - appearing airways located varying distances from the tumors.

NYGC computational biologists and members of the Simon Laboratory at The Rockefeller University discussed the possibility of using a series of computer algorithms to search for sequence differences between the tumor samples and samples of healthy liver tissue.

It can be used in computer simulations to optimize the destruction of tumors in radiotherapy while sparing healthy tissue,» highlights Professor Matthias Kling of the impact of the work.

The current clinical trial uses information of air movement from existing 4D CT data and «some equations,» says Vinogradskiy (diplomatically) to calculate lung function in tissue surrounding tumors.

«Prior research in the field has primarily focused on using knowledge from tumor tissue sequencing to identify specific changes to look for in circulating tumor DNA.

A few years ago Peperstraete stumbled on an article in a science journal about medical researchers using crossed laser beams to image and heat tumors in a patient without disturbing any of the surrounding tissue.

Researchers believe it is the largest epigenetic study yet for any single cancer type and, importantly, the first to use a large cohort of primary patient tumor tissues instead of cell lines grown in the laboratory.

And existing contrast agents — chemicals injected into the body to make tumors visible — leave the tissues too quickly to be used in a lengthy, whole - body MRI.

When antibodies and other methods were used to dramatically deplete the supply of Tregs in mice, the researchers saw a dramatic jump in the numbers of activated dendritic cells and CD8 + T cells in pancreatic tumor tissue, as well as a slowing of tumor growth.

The vaccine, HSPPC - 96, is produced individually for each patient using that patient's own resected tumor tissue.

Scientists think high levels of either protein could encourage tumor growth using similar pathways that they use to spur breast tissue growth.

For this purpose, they use certain enzymes, proteases that break down the tissue surrounding the tumor, thus opening the way for tumor cells to reach blood or lymphatic vessels.

Past clinical trials of stem cell therapies for chronic stroke patients used cells derived from tumors in humans and brain tissue from fetal pigs.

The safe use of a stem - cell - based therapy against brain metastasis would require preventing the engineered cells from persisting within the brain, where they could affect normal tissue and possibly give rise to new tumors.

Scientists could also use the printed tissue constructs to shed light on activities of living tissue that require complex architecture, such as wound healing, blood vessel growth, or tumor development.

Perform protein extraction from tumor tissue or cell pellets, upon request (with additional charge), for use in the reverse phase protein array studies (see pricing below).

Evidence of the nanoparticles in tumor tissue was found using fluorescence microscopy, a technique capable of detecting the chemotherapeutic drug (camptothecin) attached to the nanoparticle.

Sedation is often used to help patients stay in the exact position needed so radiation hits the tumor and not nearby healthy tissue.

We are using mouse models in conjunction with human tissue analysis to understand how this fibrosis arises and how it can be altered to allow access of chemotherapeutic agents to the tumor.

Avoiding the pluripotent state is important because it avoids the potential danger that «rogue» iPS cells could develop into a tumor if used to replace or repair damaged organs or tissue.