Sentences with phrase «uses allele frequency»

When IR values were adjusted using allele frequencies in village dogs, the mean IRVD value for English bulldogs rose to 0.34, with 50 % of dogs having even greater values.

Not exact matches

Using Atlantic killifish (Fundulus heteroclitus), the researchers examined whether mitochondrial - nuclear interactions alter the frequency of alternative forms of a gene that arise by mutation, called alleles, for over 11,000 nuclear DNA sequence variations within a population of the fish with mixed ancestry.

The process then evaluates the frequency of these alleles, using the results to chart disease progression and assess the effectiveness of treatment.

Because alleles carry neighboring DNA with them as they circulate, the number of singletons on nearby DNA can be used as a rough molecular clock, indicating how quickly that allele has changed in frequency.

Our approach differs from that adopted by Charlesworth [61], [62], who developed mathematical models to formalize the mutation accumulation hypothesis [63] that, together with the antagonistic pleiotropy hypothesis [3], [64], may be used to show how senescence can evolve by the accumulation of deleterious alleles through mutation - selection balance at frequencies that increase with their age of onset; such mutations enhance reproductive performance early in life but diminish survival late in life through physiological trade - offs.

Eigenstrat genotype file formats were generated per window using convertf from the EIGENSOFT package52 and custom scripts were used to convert the genotype files into matrix formats for visualization using matrix2png53 using a filtered subset of SNPs (minor allele frequencies between 0.05 and 0.49) for easing visualization of the matrices.

Double - strand validation was also used to check that the heteroplasmic alleles were present on both DNA strands at a frequency of at least 1 % [20, 38].

Estimation of allele frequency and association mapping using next - generation sequencing data.

Results of this study has shown that there is a significant inter-population variability, as far as pharmacogenomic biomarker allele frequency is concerned, which has a direct impact on the rationalization of drug use at a population level.

Estimation of allele frequency and association mapping using next - generation sequencing data Kim, S. Y., K. E. Lohmueller, A. Albrechtsen, Y. Li et al. 2011.

Using large - scale empirical and simulated data sets, we found that the sample sizes used in the HapMap project are sufficient to capture common variation, but that performance declines substantially for variants with minor allele frequencies of < 5 %.

The polyT repeat in intron 6 of TOMM40 (rs10524523) was genotyped using fluorescence - based fragment size analysis (Supplemental Figure 1; http://neuroscienceresearch.wustl.edu/pages/cruchaga2011.aspx).19 A detailed explanation of the fluorescence - based fragment size genotyping, quality control steps, allele frequency, and linkage disequilibrium between the studied polymorphisms can be found at http://neuroscienceresearch.wustl.edu/Pages/cruchaga2011.aspx.

Therefore, we developed THE REAL McCOIL, Turning HEterozygous SNP data into Robust Estimates of ALelle frequency, via Markov chain Monte Carlo, and Complexity Of Infection using Likelihood, to incorporate polygenomic samples and simultaneously estimate allele frequency and COI.

Rarecoal is a new framework to calculate the joint allele frequency spectrum across multiple populations using rare alleles.

When a breed population carries a high frequency for a known detrimental allele at a specific genetic locus, it may be possible to crossbreed with an animal free of the detrimental allele and then backcross to the original lineage, monitoring the presence of the desired allele using genetic testing.

HUU test A DNA test for the hyperuricosuria mutation is now available and may be used by breeders to decrease the mutant allele frequency in breeds that carry the mutation.

This study examines genetic diversity among 102 registered English Bulldogs used for breeding based on maternal and paternal haplotypes, allele frequencies in 33 highly polymorphic short tandem repeat (STR) lo...

This approach is most effective if many breeds are used or if mixed breed animals are used in addition to purebreds to reduce the false positives due to breed differences in allele frequencies.

A weakness of the correlational approach used here is the degree to which this pattern of results could occur as a result of random processes such as genetic drift (fluctuations in allele frequency due to chance; Keinan et al., 2007).

Data were submitted to structure using 34 markers with models specified as «admixture» and «allele frequencies correlated» and 500,000 burn - in and 500,000 Markov chain Monte Carlo iterations (39).

Consistent with our earlier finding using a larger dataset, across 12 nations, the frequency of S allele carriers of the 5 - HTTLPR was a significant positive predictor of cultural values of individualism — collectivism (β = 0.94, p < 0.05).