The researchers say the technique, which
uses cellular reprogramming, could be a new way to combat obesity and type II diabetes.
Srivastava is
using cellular reprogramming to treat heart failure and replace dead cells after a heart attack.
Not exact matches
«Eventually you have to replace those genes with small molecules, with proteins, with whatever,» says Ding, who is working on
cellular reprogramming methods that
use small molecules, rather than viruses.
The Salk team
used a partial
cellular reprogramming approach that did not cause tumors or death.
The team demonstrated that cell sex considerably influenced
cellular uptake of nanoparticles and found that cells from men and women responded differently to
reprogramming techniques
used to enhance the ability of the cells to differentiate into a greater variety of cell types.
In recent years, Muotri and colleagues have created in vitro
cellular models of autism
using reprogrammed induced pluripotent stem cells (iPSC) derived from discarded baby teeth of children with autism, work dubbed the «tooth fairy project.»
In the Nature Communications study, UTSW researchers also reported how miR - 17 causes cyst proliferation: the molecule essentially
reprograms the metabolism of kidney cells so that
cellular structures called mitochondria
use less nutrients, freeing up resources to instead make cell parts that become cysts.
Using a process called
cellular reprogramming, the researchers take a patient's skin cells, convert them into so - called induced pluripotent stem (iPS) cells, which can differentiate into all the cells within the human body.
To make iPS cells, scientists
use a technique called
cellular reprogramming.
Secondly, before considering the
use of iPSC - derived organoids for transplantation / regenerative medicine in human patients, the current protocols for expansion,
reprogramming and differentiation of iPSCs in long - term cultures need further improvement to minimize the risk of oncogenic
cellular mutations and teratoma, or tumor formation, in the patient.
Sergiu P. Pasca, 36, assistant professor of psychiatry and behavioral sciences at Stanford,
uses models of the human brain — created through
cellular reprogramming technology — to explore the biological underpinnings of brain diseases like autism.
However, direct
cellular reprogramming that does not involve a stem cell state solves some of the safety concerns surrounding the
use of stem cells.
Reprogramming of
cellular identity
using exogenous expression of transcription factors (TFs) is a powerful and exciting tool for tissue engineering, disease modeling, and regenerative medicine.