But even
using animal cells can be a terrific way to test and research the effect of experimentation on humans: Many of the cellular processes and functions are quite similar between organisms.
«In addition to organ transplants there could also be potential for
using animal cells, where transplants of pancreas cells could help the many diabetes sufferers.
The team tested their theory
using animal cells.
While startups like Impossible Foods are focused on developing plant - based alternatives to the proteins that give meat its flavor, Future Meat Technologies and Memphis Meats are trying to
use animal cells themselves to grow meat, rather than basically harvesting it from dead animals.
Not exact matches
In Brooklyn, Modern Meadow, backed by $ 53 million from investors, creates «leather»
using engineered
cells rather than
animal skins.
Bethencourt and Shigeta figured they could
use cell cultures to grow meat without slaughtering any cows or chickens — but why rely on those
animals at all?
The increasing
use of in - vitro - fertilisation techniques, and the emergence of new possibilities involving human cloning, mixing of human and
animal genetic elements, and the
use of embryonic stem
cells for research, among other things, brought the need for further teaching.
The term «egg» is
used differently outside the
animal kingdom, for an egg
cell (sometimes called an ovum).
Where is the clear line in a progression from (1)
using animal insulin to treat diabetes, to (2)
using gene remodeling techniques to grow insulin in a host bacterium that will reproduce rapidly and from which a plentiful supply of insulin can be harvested, to (3) genetic surgery to replace the defective gene in a person diagnosed as diabetic, to (4) genetic surgery immediately after fertilization in order to replace the defective gene and alter the germ
cells which would otherwise have transmitted the disease to one's offspring?
While some still object to
cells being taken from
animals and
used by scientists to grow clean meat in laboratories — and some just don't like the idea of eating a «cultured» steak created by men and women in white coats — others see the lab - grown meat revolution as key to solving the environmental crisis linked to meat eating.
The lab - grown meat — which the company calls «clean meat» — is developed from self - reproducing
cells taken from a chicken, with the purpose of creating a product that omnivores can't distinguish from the real thing, but with a fraction of the considerable downsides of meat production, including environmental destruction and
using agricultural land to grow
animal feed rather than crops for human consumption.
Thermal pre-treatment — Heating slurry for hygienisation (
animal products), protein denaturation and
cell autolysis,
used in combination with enzymatic, chemical or mechanical pre-treatment.
Alternative protein sources may include the
use of by - products currently viewed as waste or the development of new protein sources from plants, lower order
animals, or single -
cell organisms with a lower environmental impact compared with typical
animal - based protein sources.
Researchers at the European Union Reference Laboratory for alternatives to
animal testing developed five different tests that
use human blood
cells to detect contaminants in drugs that cause a potentially dangerous fever response.
Explore how
animals have evolved an amazing variety of eyes from early clusters of light - sensitive
cells, along with often surprising ways to
use them.
Hingtgen's group is already testing how far their tumor - homing
cells can migrate
using larger
animal models.
Schmidt et al.
used high - resolution proteomics, electrophysiology, biochemistry, and immunocytochemistry on wild - type and knockout
cells and
animals to study PMCA - interacting proteins.
In
animal models, the researchers found that
using microRNA to disrupt
cells in the brain's prefrontal cortex — a region associated with complex planning and decision - making — affected learning and memory later in life.
In
animals, implanted electrodes were
used to measure the activity of individual grid
cells directly, but this is not a practical option in humans.
By
using engineered zinc - finger nucleases (ZFNs) designed to target an integrated reporter and two endogenous rat genes, Immunoglobulin M (IgM) and Rab38, we demonstrate that a single injection of DNA or messenger RNA encoding ZFNs into the one -
cell rat embryo leads to a high frequency of
animals carrying 25 to 100 % disruption at the target locus.
Combing the genetic data from a transmission study in ferrets, a team led by Thomas Friedrich, a professor of pathobiological sciences at the University of Wisconsin - Madison School of Veterinary Medicine, found that during transmission, when one
animal is infected by another through sneezing or coughing, the process of natural selection acts strongly on hemagglutinin, the structure the virus
uses to attach to and infect host
cells.
According to Raymond Geor, an exercise physiologist at Michigan State University, sled dog muscle
cells are well equipped to
use this fat because they have a higher mitochondrial density — more cellular power plants — than other
animals.
«Before this study, it was not known if it is possible to produce sufficient numbers of these
cells and successfully
use them to remuscularize damaged hearts in a large
animal whose heart size and physiology is similar to that of the human heart,» said Dr. Charles Murry, UW professor of pathology and bioengineering, who led the research team that conducted the experiment.
Nor do they need to be nourished from underneath by «feeder layers» of
animal cells which have been shown to contaminate human
cells grown, making them unsuitable for
use in medical treatments.
Again,
using mouse models of glioblastoma — this time created from brain tumor
cells that were resistant to the herpes virus — the therapy led to increased
animal survival.
Using immunostaining, the researchers counted the remaining tumor
cells; the mice treated with GD2 CAR - T
cells had a few dozen remaining cancer
cells per
animal, while each control mouse had tens of thousands of cancer
cells.
The virus, redesigned
using sophisticated protein engineering techniques, works: With its shield and its adapter, these viral gene shuttles efficiently infected tumor
cells in laboratory
animals.
Sequencing the genome of one such organism, King and her colleagues found genes that code for pieces of the same proteins
used for the binding of
cells and communication between
cells in
animals — functions that would be unexpected in such an organism.
King hypothesizes that proteins that the single -
celled ancestors of
animals used to interact with the extracellular environment — to capture bacterial prey by binding to their
cell surface and to detect chemical signals — were later repurposed to enable
cells to stick to and talk to each other.
«These cyanobacteria
use the entire
cell body as a lens to focus an image of the light source at the
cell membrane, as in the retina of an
animal eye,» says University of London microbiologist Conrad Mullineaux, who helped to make the discovery.
In this study, the Hiroshima University researchers developed an
animal model
using severely immunodeficient mice whose livers were partially populated with human
cells, in order to reconstruct elements of the human immune system.
Using animal models of precancerous polyps in the bowel, Chung and his team determined that certain types of immune
cells within a chronically inflamed intestine can become rewired, causing them — paradoxically — to contribute to disease development rather than protect against it.
«Advanced
Cell Technology has the ability to produce transgenic
animals using fetal fibroblast nuclear transfer,» claims Steve Parkinson, president and chief executive officer.
While mouse models have traditionally been
used in studying the genetic disorder, Deng said the
animal model is inadequate because the human brain is more complicated, and much of that complexity arises from astroglia
cells, the star - shaped
cells that play an important role in the physical structure of the brain as well as in the transmission of nerve impulses.
Moreover, Dolly's birth did not prove that cloning could be
used to create
animals from
cells that had been genetically manipulated.
Instead of mitochondria (the cellular engines that convert oxygen to energy, present in all other known
animal cells), these creatures contain structures resembling hydrogenosomes, the organelles that anaerobic microbes
use to generate energy.
High in the Cederberg Mountains of South Africa grows a bristly shrub that embodies the tug - of - war taking place between industrialized and developing nations over the value of genetic resources — the genes found in plant,
animal or microbial
cells used for research as well as in commercial products, such as enhanced seeds and naturally derived cosmetics and pharmaceuticals.
Often times we'll
use an
animal model or
cell culture model to test a bioactive to see if it has efficacy.
In one such approach, researchers surgically remove brain
cells,
use viruses to transfer genes to the
cells, and then graft them back into the
animal's brain tissue.
«The mixtures of
cells under debate are called chimeras,» and
animal chimeras are
used «in a range of developmental biology and stem
cell experiments.
But, counter-intuitively, this mass
cell death might be the very thing that makes the
animals so long - lived: it could be a natural mechanism their bodies
use to clear precancerous
cells, stopping tumors in their tracks.
To correct bias, the National Institutes of Health will ask researchers to
use more female
animals and
cells in research.
Thus, in order to successfully produce the main types of «the energy currency» under a high concentration of hydrogen sulfide, the intestinal microflora inhabitants should
use a unique type of terminal oxidases, which is missing in the
cells of humans and
animals,» says Vitaly Borisov.
B: Well, we were in the midst of experiments aiming to
use an
animal virus to introduce new genes into human
cells and into bacterial
cells.
To better determine the role of specific chemoattractants in type III hypersensitivity, lead author Yoshishige Miyabe, MD, PhD, a research fellow in Luster's lab,
used multiphoton intravital microscopy — an imaging technology pioneered for studies of immune
cell movements in living
animals by CIID investigator and co-author Thorsten Mempel, MD, PhD — to follow in real time the development of IC - induced arthritis in a mouse model of rheumatoid arthritis.
The same signals that embryonic
cells use to decide whether to become nerves, skin or bone come into play again when adult
animals are learning whether to become afraid.
Using a novel approach for imaging the movement of immune
cells in living
animals, researchers from the Massachusetts General Hospital (MGH) Center for Immunology and Inflammatory Diseases (CIID) have identified what appear to be the initial steps leading to joint inflammation in a model of inflammatory arthritis.
Now, the researchers have discovered an alternative in a mouse model: in the case of breast tumours with a specific defect in DNA repair, the
animals can be cured
using already established, cheap chemotherapy drugs, if enough DNA damage can be inflicted on the resting tumour
cells.
Each tentacle is covered with stinging
cells (cnidocytes) that can stun or kill other
animals: most jellyfish
use them to secure prey or as a defense mechanism.
Researchers have discovered that, like plants and invertebrate
animals, mammals
use the RNA interference (RNAi) process to destroy viruses within their own
cells.