Sentences with phrase «using animal models»

Many human treatment protocols were developed using animal models.

Another study showed that women who were light drinkers had less weight gain and less risk of obesity than those who drank no alcohol, in addition a study using animal models found that the resveratrol also helped increase exercise endurance.

Long - term human studies focusing on hypertrophy and body fat loss were preferentially selected; however, acute studies and / or studies using animal models were selected in the absence of adequate long - term human studies.

SAN FRANCISCO, CA — Using animal models, scientists at the Gladstone Institutes have discovered how a protein deficiency may be linked to frontotemporal dementia (FTD)-- a form of early - onset dementia that is similar to Alzheimer's disease.

She also speculates that interspecies transmission of microbes — from dogs to humans, say, or the other way around — could affect interspecies altruism, another prediction that could be tested using animal models.

An impressive patient account exemplified how novel therapies developed using animal models improve human health and saves lives.

In this interview, Dr. Haller discusses the possibility of utilizing stem cells to generate new kidneys, including using animal models to understand the pathways involved, 3D bio-printing and the timeline to the clinic.

Researchers at the MDI Biological Laboratory have been using animal models beyond the well - known laboratory mouse for decades.

Dr. Tarazi studies the behavioral, genetic, molecular, and cellular mechanisms that mediate the actions of dissimilar psychotropic drugs by using animal models that mimic the core symptoms of different neuropsychiatric diseases.

Researchers at McLean's Behavioral Genetics Lab are using animal models to study the effects of nicotine on vulnerability to post-traumatic stress disorder (PTSD) in a study funded by the Department of Defense (DoD).

We carry out translational research programmes to develop infectious disease vaccines, therapeutics and diagnostics using animal models of tuberculosis, influenza, HIV / AIDS, Clostridium difficile, meningococcal disease, chlamydia, burkholderia and anthrax, as well as emerging viral diseases such as Crimean Congo haemorrhagic fever.

«So we showed, using these animal models, a link between the changing microbiome and changing inflammation, which contributes to insulin resistance,» Kahn says.

Using animal models and cells, Counter and colleagues found that when they experimentally inhibited copper uptake by tumors with the BRAF mutation, they could curb tumor growth.

No, studies using animal models of human disease as well as «humanized mice» are expressly forbidden.

Scientists at the University of Bonn working with Prof. Dr. Alexander Pfeifer, Director of the Institute for Pharmacology and Toxicology, have spent years using animal models to explore how the undesirable white fat can be converted into sought - after brown fat.

«Although this is basic scientific research using animal models, these studies are shedding light on the molecular mechanisms that control male fertility, and are helping us to better understand the causes of many cases of infertility and enabling new horizons to be opened up in the development of therapeutic targets and strategies to combat it,» explained Dr Subirán.

«Traditional methods of infectious disease research using animal models have provided limited information about disease progression until the study's endpoint, when investigators could analyze tissues from those animals,» he said.

«As researchers, our goal is to understand the details of how these molecules are locked,» says Thompson, adding that they will be using animal models to conduct this research.

Using animal models, Pickles has already found candidate molecular biomarkers that indicate if the epithelial cells in the tiniest airways are expressing the RSV NS2 protein.

The researchers hope these findings will aid in developing new treatments by using animal models that more closely represent the types of mutations apparent in the vast majority of patients with enchrondromas.

Its research includes a cluster of related interdisciplinary projects that examine disparities in breast cancer mortality between African - American and Caucasian women using animal models, molecular characterization of tumors, and behavioral research focused on social - environmental factors.

Using animal models of precancerous polyps in the bowel, Chung and his team determined that certain types of immune cells within a chronically inflamed intestine can become rewired, causing them — paradoxically — to contribute to disease development rather than protect against it.

Most of the studies that have produced the craze over PRP have been done using animal models.

To demonstrate the effects of bullying, the researchers used an animal model simulating the physical and emotional stressors involved in human bullying — chronic social defeat stress.

«Our results using an animal model suggest that a maternal high - fat diet during pregnancy and lactation could have significant and lasting effects on the brain, behavior and cognition of rat pups,» said Dr. Tamashiro.

Page and his colleagues, who use animal models to understand how autism risk factors impact the developing brain and to identify potential treatments for the condition, have found that animals with mutations in the autism risk gene phosphatase and tensin homolog (Pten) mimic aspects of autism, including increased brain size, social deficits and increased repetitive behavior.

Researchers performed a meta - analysis of literature examining patients with NASH, and then tested their hypothesis using an animal model, which enabled them to eliminate possible confounders of the clinical data, such as antibiotic exposure and medical comorbidities.

Often times we'll use an animal model or cell culture model to test a bioactive to see if it has efficacy.

Using an animal model, the research team replicated cocaine addiction by allowing rats to self - administer as much cocaine as they wanted (up to 40 doses) during a six - hour period.

Study using animal model provides clues.»

Using an animal model, the UAB researchers found that a lack of Sp7 interrupts the maturation of two types of specialized cells that help create teeth.

Researchers used both animal models and human cells to demonstrate the hyper - responsiveness of MAIT cells to systemic exposure to bacterial superantigens.

In order to gain a better understanding of this process, the researchers used an animal model, which allowed them to interfere with the lipid metabolism, and to knock out the gene responsible for the relevant enzyme, adipose triglyceride lipase (ATGL).

It could be used to diagnose almost any human disease, sometimes before symptoms appear, help identify new drugs, and even change the way we use animal models to understand disease.

In the study, Bruce Hope, from the National Institutes of Health National Institute on Drug Abuse Intramural Research Program in Baltimore, Maryland, and colleagues used animal models to investigate if the brain forms drug - related memories in a similar way.

«When you use animal models and do the things that are commonly done in assisted reproduction, the answer is yes — it affects DNA methylation.»

We also want to use this system to explore which substances could counteract the progress of neurodegeneration in the brain without having to use animal models at this early stage.

Using an animal model of this syndrome, scientists from the Florida campus of The Scripps Research Institute (TSRI) have discovered that mutations in PTEN affect the assembly of connections between two brain areas important for the processing of social cues: the prefrontal cortex, an area of the brain associated with complex cognitive processes such as moderating social behavior, and the amygdala, which plays a role in emotional processing.

Using an animal model, they found that TIMP - 1 recruits immune cells by increasing the levels of a specific signaling molecule in the liver.

Pandey performed the experiments using an animal model during which rodents were exposed to alcohol for a long period of time.

«By using an animal model to expand tumor cells recently removed from patients, we hoped to re-create more closely what actually happens in patients with pancreatic cancer rather than by using existing artificial cell lines,» said Wei Zhang, Ph.D., an endowed Hanes and Willis Family Professor in cancer at Wake Forest School of Medicine, a part of Wake Forest Baptist, and principal investigator of the study.

The current study, and studies like it that use animal models, could contribute to determining human health risks and developing policies leading to a reduction in both exposure to THS and disease.

Instead, the experts used animal models to show how the chemical — called triclosan — was harmful.

Kinney's research team used animal models to seek out answers.

However, most studies used animal models, and there is still a knowledge gap regarding sex dimorphism in human diabetic cardiomyopathy (311).

Now, in a paper published online today in Nature Neuroscience, Dr. Kreitzer and his team used animal models to demonstrate that this imbalance may also contribute to psychiatric disorders.

Dr. Nociari uses animal models, cell culture, and clinical approaches to study from different perspectives the impact that lipofuscin accumulation has in retinal disease.

To do this we need to understand how this mechanism works normally, so we will test this therapeutic approach using an animal model where the pathway regulating normal retinal blood vessel growth has been removed genetically.

«Using an animal model that's relevant to human disease, Fouchier and Kawaoka have shown that relatively few mutations may be required for an influenza virus to evolve into astrain that can pass effectively between individuals and cause serious illness.

Instead of focusing on marine animals, they use animal models such as freshwater zebrafish, salamanders, fruit flies and nematode worms that share many of their genes with humans.