Sentences with phrase «using animal models of human disease»

No, studies using animal models of human disease as well as «humanized mice» are expressly forbidden.

Not exact matches

These findings allowed researchers to create a chimera virus: a mouse virus with a human viral gene that can be used to test molecules that inhibit human LANA protein in an animal model of disease, treating not only human herpes virus infection but also its associated cancers.

«We know that urate has neuroprotective properties in animal models, and an unusual convergence of human studies suggested its possible use as a disease - modifying strategy in Parkinson's; so the positive results of this trial are very encouraging.»

Most animal studies of the disease are conducted with laboratory mice that have been genetically engineered and bred to model ALS, but for this research, investigators used rats with ALS because they more accurately portray the disease's variable course in humans.

Animal models are often used to replicate human disease; the relevance and similarity between animal models of joint disease and human osteoarthritis has not been fully evalAnimal models are often used to replicate human disease; the relevance and similarity between animal models of joint disease and human osteoarthritis has not been fully evalanimal models of joint disease and human osteoarthritis has not been fully evaluated.

In a novel animal study design that mimicked human clinical trials, researchers at University of California, San Diego School of Medicine report that long - term treatment using a small molecule drug that reduces activity of the brain's stress circuitry significantly reduces Alzheimer's disease (AD) neuropathology and prevents onset of cognitive impairment in a mouse model of the neurodegenerative condition.

«It has the potential to inform clinical practice and also guides us about the relevance of animal models of human disease and how we can reduce and refine their use.»

Such ease of use will likely encourage the use of more animal models in the study of human diseases, says Rhonda Wiler, a geneticist at biotech giant Genentech in San Francisco, California, who co-chairs the Roundtable on Science and Welfare in Laboratory Animal Use (which organized the workshouse will likely encourage the use of more animal models in the study of human diseases, says Rhonda Wiler, a geneticist at biotech giant Genentech in San Francisco, California, who co-chairs the Roundtable on Science and Welfare in Laboratory Animal Use (which organized the workshouse of more animal models in the study of human diseases, says Rhonda Wiler, a geneticist at biotech giant Genentech in San Francisco, California, who co-chairs the Roundtable on Science and Welfare in Laboratory Animal Use (which organized the workanimal models in the study of human diseases, says Rhonda Wiler, a geneticist at biotech giant Genentech in San Francisco, California, who co-chairs the Roundtable on Science and Welfare in Laboratory Animal Use (which organized the workAnimal Use (which organized the workshoUse (which organized the workshop).

My research combines the use of mathematical models and statistical methods to understand the transmission dynamics and control of a range of infectious diseases of humans and animals.

This animal model closely resembles lesion kinetics as seen in human disease [34] and use of non-human primates allows for repetitive surgical sampling for multiple time point analysis.

Katherine W. Klinger, PhD, Senior Vice President for Genetics and Genomics at the Genzyme Corporation, and Assistant Clinical Professor in the Department of Pediatrics at the University of Connecticut School of Medicine suggested that for an orphan disease it may be necessary to use multiple animal models in the preclinical research stage, because one animal model may not fully recapitulate the human disease.

His major research interests are human neuroanatomy and neuropathology and the use of animal models to test novel therapies for neurodegenerative diseases including Alzheimer's disease.

FOA encourages research grant applications from institutions / organizations that propose to develop, characterize or improve animal models for human disease or to improve diagnosis and control of diseases that might interfere with animal use for biomedical research purposes.

Since 2006 when Biomedcode was established, we have evaluated hundreds of therapeutics including novel biologics, biosimilars, biobetters and small molecules using a unique array of animal disease models closely mimicking the complexity of human inflammatory conditions.

One potential reason for this discrepancy is that the laboratory tests used in animal models of the disease do not resemble the clinical assessments given to patients, and thus are not predictive of human memory performance.

Because of the pivotal role that diet plays in causing the MS in humans, most metabolic disease animal models do (and we believe should) use diet as a way to precipitate this syndrome.

Examples of studies conducted with assistance of the Center are pre-clinical studies of orthopedic devices intended for animal and human use, clinical studies of treatment and prevention of respiratory diseases in horses and animal clinical trials evaluating the treatment of bladder cancer in Scottish Terriers, an animal model of human bladder cancer.