These findings were achieved
using brain tissue samples from two patients with AD and a control.
Not exact matches
Researchers most commonly study the effect of antidepressants
using a technique known as microdialysis, in which they insert a probe into the
brain to take tiny chemical
samples from the
tissue.
Boyden and colleagues first described the underlying technique, known as expansion microscopy (ExM), last year, when they
used it to image proteins inside large
samples of
brain tissue.
Once testing was complete,
brain images,
tissue and blood
samples were
used to analyze changes to
brain structure and cytokine activity (proteins released by the immune system to help fight off infections or diseases).
They
used state - of - the - art DNA sequencing technology to screen for retrotransposons in
tissue samples taken postmortem from three individuals who were healthy when alive and had no neurological disease or signs of abnormality in their
brain tissue.
Usually, because of the inaccessibility of
brain tissue in living humans, epigenetic studies are carried out
using blood
samples.