Sentences with phrase «using chimeric»

Over the past two years, investigators from the Perelman School of Medicine at the University of Pennsylvania have reported results from a human trial in GBM using chimeric antigen receptor (CAR) T cell therapy, through which patients» own T cells were engineered to track down and kill cancer cells that express a tumor - specific protein known as EGFRvIII.

Not exact matches

Linked RNA - DNA pairs are selectively fished out, then converted into chimeric sequences that can all be read at once using high - throughput sequencing.

Researchers at The University of Texas MD Anderson Cancer Center developed a novel chimeric mouse model to test the combination therapy using immune checkpoint blockades with therapies targeting myeloid - derived suppressor cells (MDSCs).

Fifteen years ago, Campana helped develop the chimeric antigen receptor that's used in Kymriah today.

Hybrid, or chimeric, animals may eventually grow human organs to be used in transplants.

McCain would ban scientists from using donor eggs to create disease - specific stem cell lines or chimeric animals to see how human stem cells behave during development.

After giving the cells a week to get used to each other, the scientists implanted the chimeric concoction into the protective tissue surrounding the kidneys of living mice.

Although it wasn't the first time chimeric pigs were created, it was the first time they came about using cloned pluripotent cells.

The world's first chimeric monkeys were created in a laboratory last year, and they offer surprising new insights into embryonic stem cell therapy: One reason for often - poor treatment outcomes may be that we're using embryos that are, strangely, just too old.

North says his group has already generated a human chimeric form of MAG - 1 that is equally effective as mouse MAG - 1, and they are now generating a humanized form for use in patients.

Zelig Eshhar and colleagues first use the T - body approach, employing chimeric receptors composed of an antibody recognition unit linked to T cell activation domains, to redirect T cells to recognize and attack tumor cells.

Chimeric mice generated from cells reprogrammed for pluripotency (induced pluripotent stem cells, or iPS cells) show significant health problems, pointing to further challenges that must be overcome before such cells can be used in the clinic, noted iPS researcher Shinya Yamanaka said on Saturday (June 14).

Tisagenlecleucel is a one - time injection of chimeric antigen receptor (CAR) T cells manufactured for an individual patient using their own cells.

Diagram of the complete synthetic signal transduction system in transgenic plants, using TNT as the ligand, signaling through the bacterial chimeric histidine kinase, and adapted response regulator, then activating a transcriptional response.

Hanner and Rusche used chromatin immunoprecipitation assays to show that this chimeric protein did not make it to the HMRa or HMRα loci or to other repressed genes.

«This shows that our chimeric mouse model is medically relevant and can be used to validate novel drugs in a pre-clinical setting,» says Bissig.

The technology is called Chimeric Antigen Receptor T - cell therapy (CAR - T), which uses a patient's own immune cells to fight cancer.

For this reason it is virtually impossible to determine specific protein turnover or temporal expression using standard FP - chimeric proteins.

Interestingly, the chimeric mice can be directly used to monitor tumor development as they contain the same genetic alterations as the original GEMM including the altered target gene expression.

In a similar way, we used HV lacZ ES cells to ask whether the V+S + fraction would preferentially segregate to the outside of chimeric EBs.

Using the subgerminal cavity injection method with a Cas9 - strain of Rock Pigeons would allow the observation of phenotypes in the first chimeric generation; saving time on selecting individuals for breeding pure, fully - edited strains of genotypes that successfully capitulate the desired phenotype.

Chimeric antigen receptor T cells (CAR - Ts) are a type of engineered T cell used in adoptive T cell transfer.

SAN DIEGO, March 28, 2017 (GLOBE NEWSWIRE)-- Invivoscribe ® Technologies Inc., a global company with decades of experience providing internationally standardized clonality and biomarker testing solutions for the fields of oncology, personalized molecular diagnostics ®, and personalized molecular medicine ®, reports that its next - generation sequencing (NGS) LymphoTrack ® Assay kits are being used by its LabPMM ® clinical laboratories, pharmaceutical partners, and cancer centers to identify and monitor chimeric antigen receptor T - cells (CAR - T) and engineered T - cell receptors in peripheral blood of subjects in support of immuno - therapeutic drug development and treatment regimen development for both hematologic and solid tumors.

The use of anti-CD19 chimeric antigen receptor T cells induced a nearly sixfold higher rate of complete response compared with historical outcomes in patients with refractory, aggressive non-Hodgkin lymphoma.

In addition, mixed lymphocyte cultures using the cells of the chimeric animals as responder cells to donor splenocytes failed to demonstrate any sensitization or clonal deletion of alloreactive T cells; i.e. T cell responses were identical to those of control animals (n = 4)(data not shown).

Attempts to test the intrinsic role of S1pr1 using BM chimeras were unsuccessful due to difficulties in achieving efficient reconstitution of IL7RαhiCcr6 + cells and our finding that many of the cells developing in the chimeric mice appeared activated based on CD69 expression (not shown).

These three artists share a penchant for the garish and provocative: through the use of bold colors and tantalizing aesthetics, their artworks portray disconcerting human stereotypes as well as chimeric monsters.