Using diabetes and obesity as framework, Phenobridge will increase the relevance of data that is generated in mouse studies to be further applied in clinical studies.
Harmonising ontological descriptions of phenotype in mouse and human and improving links between mouse model data and human data,
using diabetes and obesity as examples, will increase the relevance of data that is generated in mouse studies for clinical studies.
Not exact matches
This technique has been
used, as Arnold reports, to trace the progress of cancers, advance our understanding of
obesity and diabetes,
and prove that brain cells continue to form through a human being's lifetime.
In recent years, Levine
and others have
used clinical studies to prove that even in healthy people, a chair - based lifestyle sets up the physiological conditions for the onset of Type 2
diabetes, cardiovascular disease,
obesity —
and ultimately, shorter lifespans.
It's the same rationale the Meatless Monday campaign
uses to validate the claim that forgoing meat one day a week can lower your risk for cancer, cardiovascular disease,
diabetes and obesity.
It is believed that one of nopalitos (nopal cactus) properties is a natural
diabetes and cholesterol medication,
and its also
used in the treatment of
obesity, gastrointestinal disorders, skin ailments,
and viral infections.
These findings — published in the June 2014 editions of Molecular Nutrition
and Food Research — suggest this ingredient's
use as a plausible tool in the comprehensive management of metabolic syndrome (MetS), which is defined as a cluster of heart attack
and cardiovascular disease risk factors, including
diabetes / prediabetes, abdominal
obesity, dyslipidemia
and hypertension.
The sap from the agave plant is collected
and processed to make agave nectar, which — like stevia — should be
used with a bit of caution due to the sweetener's high fructose content, which has been attributed to metabolic syndrome,
obesity,
and diabetes.
Exclusive
use of formula, meanwhile, was associated in independent studies in the 1990s
and 2000s with asthma, allergies,
diabetes,
obesity, skin rashes
and ear
and respiratory tract infections.
Since I started blogging, I've become better acquainted with two school nurses (one a new friend, one who serves with me on Houston's Student Health Advisory Council)
and now realize that it's often school nurses who are on the front lines of the childhood
obesity crisis, conducting
diabetes screenings
and BMI evaluations,
and using those few precious minutes with students to try to educate them as much as they can about nutrition
and health.
Long - term (≥ 18 years) maternal recall of breastfeeding duration has been
used in studies of the association of infant feeding with adult
obesity (32), adult vascular function (10),
and both child -(33, 34)
and adult -(8) onset
diabetes.
Experiments with a compound called TNP [N2 -(m - Trifluorobenzyl), N6 -(p - nitrobenzyl) purine], which researchers often
use to study
obesity and diabetes, show that in mice the therapy can promote the formation of new bone.
The study finds a correlation between the
use of the medication fluoxetine during pregnancy
and an increased risk of
obesity and diabetes in children.
«
Obesity and Type 2 diabetes in children is on the rise and there is the argument that it is related to lifestyle and availability of high calorie foods and reduced physical activity, but our study has found that maternal antidepressant use may also be a contributing factor to the obesity and diabetes epidemic,» said the study's senior investigator Alison Holloway, associate professor of obstetrics and gynecology at McMaster Univ
Obesity and Type 2
diabetes in children is on the rise
and there is the argument that it is related to lifestyle
and availability of high calorie foods
and reduced physical activity, but our study has found that maternal antidepressant
use may also be a contributing factor to the
obesity and diabetes epidemic,» said the study's senior investigator Alison Holloway, associate professor of obstetrics and gynecology at McMaster Univ
obesity and diabetes epidemic,» said the study's senior investigator Alison Holloway, associate professor of obstetrics
and gynecology at McMaster University.
Understanding the brown fat tissue
and how it can be
used to such ends is of growing interest in the search to help people suffering from
obesity or at a high risk of developing
diabetes.
«In post-industrial environments where foods are abundant
and readily available, our cravings for fat
and sugar sculpted by distant evolutionary pressures can easily go into insatiable overdrive
and lead to
obesity,
diabetes,
and heart disease -LRB-...) the pro-social needs
and rewards [of smartphone
use as a means to connect] can similarly be hijacked to produce a manic theatre of hyper - social monitoring,» the authors write in their paper.
Greater exposure to Medicaid during early childhood was associated with a significant
and meaningful improvement in midlife health
using a composite index that combines information on high blood pressure,
diabetes, heart disease / heart attack,
and obesity.
What the researchers found
using this technique could have significant impact on both the understanding
and treatment of
obesity,
diabetes and cardiovascular disease.
«When we
use labels like «black» or «African», they are gross approximations,» agrees Charles Rotimi of the National Human Genome Research Institute in Bethesda, Maryland, who studies the influence of culture, lifestyle
and genetics on patterns of
obesity, hypertension
and diabetes in African Americans.
The researchers say the technique, which
uses cellular reprogramming, could be a new way to combat
obesity and type II
diabetes.
Gila lizards produce exendin - 4, a small venom protein
used in the treatment of
diabetes and obesity, which is a competitor to Victoza ® — produced by Novo Nordisk.
Researchers at the University of California, Riverside have tested a genetically - modified (GM) soybean oil
used in restaurants
and found that while it induces less
obesity and insulin resistance than conventional soybean oil, its effects on
diabetes and fatty liver are similar to those of conventional soybean oil.
We believe that this new information on the structure of the adiponectin receptors will help us understand new relationships between the structure
and functions of these important receptors, which we know to be evolutionarily conserved,
and hopefully will contribute to the development of new adiponectin receptor agonists that can be
used for the treatment of
obesity - related diseases such as type 2
diabetes.
And the imprudent use of antibiotics has contributed worldwide to epidemics of chronic diseases, such as obesity, diabetes and canc
And the imprudent
use of antibiotics has contributed worldwide to epidemics of chronic diseases, such as
obesity,
diabetes and canc
and cancer.
Epigenomics is presently being
used to identify inherited pre-disposition to
obesity,
diabetes, cardiovascular disease, addiction
and psychiatric disorders, as well as markers for aging
and cancer progression.
The discovery opens the door to research that might lead to new ways of
using brown fat to treat metabolic conditions such as
obesity and type 2
diabetes in the future.
The
Use of Antimicrobials as Adjuvant Therapy for the Treatment of
Obesity and Insulin Resistance: Effects
and Associated Mechanisms — Sandra Aparecida dos Reis —
Diabetes / Metabolism Research
and Reviews
Using deCODE's proprietary analysis tool for complex traits, the deCODE Clinical Genome Miner ™, the researchers were able to correlate a wide range of clinical, behavioral,
and genotypic data,
and gained important new insights into the heritability of different aspects of
obesity, as well as into the complex interplay between
obesity and diabetes, stroke, heart disease,
and hyperlipidemia.
Currently, she is
using imaging techniques to explore the effects of glucose on brain responses to food cues in children who are at - risk for developing
obesity and / or
diabetes later in life.
The report also explains the assessment that the organization
uses to address the biggest health challenges facing its service area, including cancer, adult
diabetes, trauma care
and violence prevention, sexually transmitted infections,
and pediatric
obesity and asthma.
The third webinar,
and the final one will focus on animal models of
obesity and diabetes, both talking about genetic models, as well as dietary models
and how they are
used in basic research, but also in pharmaceutical
and biotech research.
Using genomics approaches, Dr. Nobrega has identified the gene IRX3 as the strongest association to polygenic
obesity in humans,
and characterized the mechanisms by which mutations altering the expression of a gene called TCF7L2 also represent the strongest genetic link to type 2
diabetes in humans.
The center also participates in the national «MICROMouse» program, which awards competitive one - year grants up to $ 75,000 for research projects that have the potential to enhance
and advance the mission of the MMPC as a resource for scientists
using mice to study
diabetes and obesity.
The patch, tested so far only in mice, could be
used to burn off pockets of unwanted fat
and treat metabolic disorders like
obesity and diabetes, according to researchers at the University of North Carolina - Chapel Hill, NC State University,
and Columbia University Medical Center.
Ingredients like high sucrose corn syrup,
used widely in soft drinks,
and palm oil, found in a variety of processed foods, have been promoted as
and are arguably «natural» — but they have been linked to
obesity,
diabetes and a range of other diseases.
IN FACT, the Japanese Ministry of Health doesn't just approveLakanto for
use in Japan, they actually recommend it for weight loss,
obesity and blood sugar problems like
diabetes.
The most effective diets ever
used to cure people of common day illnesses, like coronary heart disease, type - 2
diabetes, hypertension, hypercholesterolemia, arthritis,
and obesity minimize animal foods
and require people eat the bulk of their calories from starches, including grains, legumes,
and potatoes (foods forbidden to Paleo eaters).
Since more than 20 years, hospitals in Japan
use alkaline water to help prevent
and cure degenerative chronic diseases such as cancer,
diabetes, osteoporosis, arthritis,
obesity and premature aging.
Long term
use of HFCS can not only cause
obesity, but also
diabetes, premature aging,
and a host of other health issues.
In addition, many of our children have what
used to be diseases only seen in adults, such as
obesity, insulin resistance, type 2
diabetes and fatty liver.
Additionally, the elevated insulin will increase D2 activity
and suppress TSH levels, further decreasing thyroid levels
and making it inappropriate to
use the TSH as a reliable marker for tissue thyroid levels in the presence of elevated insulin levels as occurs with
obesity, insulin resistance, or type II
diabetes (91 - 99,233).
Sitting for any length of time may not be good for us, as more
and more evidence shows that sedentary behaviours including sitting, watching television,
using a computer,
and driving a car are risk factors, independent of physical activity, for adverse chronic disease in adults such as
obesity,
diabetes, heart disease
and much more.
This type of diet is
used successfully in the treatment of not only unwanted body fat, belly fat,
and obesity, but also many diseases
and conditions such as acne, mood swings, depression, lack of energy, type 2
diabetes, insulin resistance, hyperactivity, asthma, food cravings, joint pains, arthritis, systemic lupus erythematosus (SLE), irritable bowel syndrome (IBS), menopause, irritability, restless legs, allergies, inflammation, food addictions, carbohydrate cravings, binge eating, etc..
Research supports the
use of coconut oil for
obesity, dyslipidemia, insulin resistance, hypertension,
and pathologically elevated LDL, all of which constitute risk factors for
diabetes, cardiovascular disease,
and Alzheimer's, the last of which is being re-conceptualized as type 3
diabetes (Fernando et al., 2015).
Our findings provide a biochemical
and nutritional basis for the
use of PCC or anthocyanins as a functional food factor that may have benefits for the prevention of
obesity and diabetes.
This strategy was made popular by Dr. Atkins but has been
used by physicians for over a century to treat
obesity,
diabetes,
and other health problems.
Incidentally, the same approach is also
used to treat various conditions like seizures, cancer,
diabetes and obesity.
Sugar in other forms are frequently added such as fruit juice concentrates, honey (which when heated
and processed for
use in manufacturing, essentially becomes sugar syrup),
and the most infamous of all, «high fructose corn syrup» (HFCS), now widely known as one of the primary contributors to
Diabetes and Obesity.
Of course, lifestyle factors have to be considered as well — we move around less on average than we
used to
and arguably experience more stress — but Mohr blames problems like
diabetes and obesity on swollen portion sizes, not an epidemic of nutritionally - bankrupt food.
Cost estimates for legislative proposals to address chronic health conditions like
obesity use a time period that is too short to capture the potential economic value of preventing related diseases such as
diabetes and heart disease.