Sentences with phrase «using gene drive»

The biotechnology company Oxitec has developed a genetically modified Aedes aegypti mosquito to suppress the population, without using gene drive.

Because the goal of using a gene drive is to spread genetic information throughout a population rapidly, it is difficult to anticipate its impact and important to minimize the potential for unintended consequences.

By using gene drive, a method targeting specific genes, they could go in and tip the scale in the mosquito's favor.

What's a pest in one place may be valued in another, so getting consent to use a gene drive could mean consulting people across a species's whole range, be it several nations or continents.

«I'm very relieved,» says Andrea Crisanti, a molecular parasitologist at Imperial College London, who is part of an effort that seeks to use gene drives to control malaria.

And we could explore when it would be smart to use gene drives, if ever, and when they'd be a colossal mistake.

MIT's Oye, for instance, raises the «most extreme scenario» of bioterrorists altering the genomes of disease - causing organisms to make them more lethal or more infectious, and using gene drives to spread that trait throughout a population.

Not exact matches

Gene drives enable a gene to spread rapidly through a population; there are plans to use them to combat mosquito - borne diseases by making the flies sterile or unsuitable as hosts for various viruses and parasiGene drives enable a gene to spread rapidly through a population; there are plans to use them to combat mosquito - borne diseases by making the flies sterile or unsuitable as hosts for various viruses and parasigene to spread rapidly through a population; there are plans to use them to combat mosquito - borne diseases by making the flies sterile or unsuitable as hosts for various viruses and parasites.

Although the whole drive to understand the molecular basis of beer production involves modern tools that are used in biotechnology, such as real - time polymerase chain reaction (PCR), gene chips, proteomics, mass spectrometers, and so forth, genetic manipulation is not acceptable in any form — not in any of the raw materials or the yeast.

To more accurately reflect the mechanisms driving oligodendrogliomas, the researchers used RNA sequencing to study directly, on a single - cell level, gene expression in samples from six early - stage human tumors.

Ecologist Ron Thresher got a sense of how the public might react to gene drives when he described his plan to use genetic engineering to rid the Australian waterways of invasive European carp, a voracious fish that can turn a crystal - clear stream into «a disgusting mudhole.»

Using the genomic technologies he's learned at the IGB, Woolbright hopes to develop a research program that investigates climate - driven changes in species interactions at the gene level.

At the time, no one had reported creating a gene drive using CRISPR.

Gene drive systems that use genetic approaches to kill mosquitoes, prevent them from breeding, or stop them from transmitting the malaria - causing parasite are under development, but a concern is that mosquitoes could evolve resistance to these techniques, too.

«I'm not used to that kind of conference,» says Messer, who says he told the group about his lab's efforts to study the evolution of resistance to CRISPR gene drives in fruit flies.

The guidelines may help researchers avoid creating an accidental gene drive, but they don't apply to gene drives that would actually be used in the wild, says molecular biologist Zach Adelman of Virginia Tech in Blacksburg.

To learn more, Zanders and her colleagues used genetic mapping to reveal the complex landscape of multiple meiotic drive genes on chromosome 3 of S. kambucha.

«The use of a radiofrequency - driven magnetic field is a big advance in remote gene expression because it is non-invasive and easily adaptable,» says Dordick, who is Howard P. Isermann Professor of Chemical and Biological Engineering and vice president of research at Rensselaer.

For example, genetically engineered organisms used in the research laboratory to develop new chemical synthesis methods are not likely to require the same level of public dialogue as products that have more uncertainty associated with them, such as organisms with gene drives, which enhance organisms» ability to pass certain genetic traits on to their offspring.

«Meiotic drive systems like wtf genes could potentially be used to eradicate pest populations or to facilitate the spread of desirable traits in natural populations,» Zanders says.

In researching and assessing potential new strategies, Campbell and his colleagues have made an argument for the use of gene drives on islands.

In 2014 Esvelt and others published a paper outlining for the first time the potential ways in which CRISPR could be used for gene drives.

In addition to providing an alternative to embryonic stem cells for potential use in regenerating diseased tissues, iPS cells are being used to learn more about diseases, especially diseases driven by mutated genes.

It did not begin to seriously discuss the risks associated with using the approach to engineer genes that could quickly spread through wild populations — known as gene drives — until after experiments demonstrating the concept in fruit flies had been published in a peer - reviewed journal (V. M. Gantz & E. Bier Science 348,442 — 444; 2015).

A third computer - driven approach lets the team simulate the process of genetic evolution over millions of generations using synthetic biological data to deduce the rules of evolution, and to identify genes that may be important for adaptation.

New strategies to control mosquitoes are being developed that use «gene drive» - using the latest Crispr / Cas 9 genetic tools to make mosquitoes infertile or unable to carry the malaria parasite.

The researchers found that gene drive is unlikely to work for most mosquito genes because they are too variable in nature, however they also used the data to highlight less variable targets that are potentially more suitable for gene drive based methods to control mosquitoes.

Thus, gene drive could be used to reduce malaria transmission in humans — or in endangered birds (see image, above)-- by making the mosquito vectors incapable of spreading the malaria parasite or even eliminating the insects altogether.

«The development, risk assessment regulation, and use of gene drives should be based on public dialog, public deliberations, and public decision - making.

Dr. Jones obtained his Ph.D. in 2003 from the University of Birmingham Institute of Cancer and Genomic Sciences (United Kingdom) under Professor Lawrence Young, studying the use of gene therapy for targeting Epstein - Barr Virus (EBV) proteins with replication - competent adenoviruses to treat EBV - driven malignancies.

That could be good news for researchers hoping to use engineered «gene drives» to eliminate mosquito - borne diseases and invasive species.

Using bioinformatics tools to identify and map out specific components and regulatory interconnections, the study team found highly dynamic activities during CD8 + T cell responses: a distinct repertoire of super enhancers — groups of enhancers that interact with promoters to drive gene transcription, new groups of enhancers that jump into activity only in the memory cell stage, and extensive re-wiring of regulatory circuits from one cell stage to another.

This is the first study in human trials to identify genes driving acute peanut allergic reactions using a double - blind placebo - controlled approach with comprehensive sequencing of genes expressed before, during, and after they ingested peanut.

The research is part of the International Cancer Genome Consortium (ICGC)-- a global project using the latest gene - sequencing technology to reveal the genetic changes driving the disease.

Cells equipped with a gene whose activity is driven by blue light were used to help diabetic mice control glucose levels.

They write that the U.S. National Academy of Sciences has recently convened a panel to discuss the potential hazards and regulation of gene drives, and to make recommendations regarding their safe use.

In spite of the difference between the cell functions responsible for giving rise to a tumour and for the metastasis of this same tumour, studies at IRB Barcelona using the fly Drosophila melanogaster reveal that some genes can drive both phenomena.

Gene drives could have widespread uses, potentially leading to new ways of combating malaria and other insect - borne diseases and controlling invasive species.

Additionally, we support and expand upon the hypothesis that X inactivation is primarily driven by gene loss on the Y. Using linear discriminant analysis, we show that X-inactivation status can successfully classify 90 % of X-linked genes into those with functional or nonfunctional Y homologs.

This presentation will discuss the use of patient - like reference materials to drive accurate patient testing and subsequent drug treatment decisions based on the presence of pathogenic EGFR gene variants.

Conversely, fundamental research using mouse models can identify genes associated with disease and provide insights into pathogenic mechanisms underlying environment - driven diseases, including infectious diseases and cancer.

«If the public ever considers making use of a gene drive, we will need to develop appropriate safeguards.

«Many different groups and the interested public will need to come together to ensure that gene drives are developed and used responsibly,» said James P. Collins, PhD, an evolutionary ecologist at Arizona State University and senior author of the Science paper.

Karl Campbell from Island Conservation reported on his organization's investigation into using gene - drive technology as potentially the most targeted, effective, and economic technique for eliminating invasive mice and rats.

The research goal is to use a naturally - occurring (t - complex) and / or CRISPR «gene drive» in mice to facilitate a bias of subsequent rodent generations to all be a single sex.

Genetically engineering mammals so they breed themselves out of existence, using a sex - biasing gene drive could be a way to remove invasive mammals — which have been extremely difficult to control on Mauritius — without harming native wildlife.

The hotly debated gene drive, which uses the gene splicing technology CRISPR, is looking to wipe out the Zika - causing Aedes aegypti mosquito population.

A self - sustaining method would require the use of a gene drive designed to persist in the environment and spread within the target population, but with some risk of spreading into a non-targeted area where that same species may be desired.

RNA - guided gene drives can theoretically be used to delete any existing gene, to edit any gene important for fitness, or to add new transgenes.

When coupled with the use of a gene drive naturally occurring in mice, this technique could ensure that all non-native mice on an infested island can be reached to affect an all - male - population unable to reproduce.