Sentences with phrase «using gene signatures»

His troubles also led to an Institute of Medicine report that faulted Duke's oversight and found broad problems in the cancer field with using gene signatures and other biomarkers to guide treatment.

Not exact matches

The researchers constructed a signature for type 2 diabetes based on 50 genes, then used publically available expression datasets to screen 3,852 compounds for drugs that potentially reverse disease.

Those trials have since been halted, but the Institute of Medicine is setting up a panel to study clinical use of these gene signatures.

More than two decades ago, in one of the first papers using gene sequences to find signatures of natural selection, scientists hypothesized that a molecular change in an enzyme gave the Drosophila melanogaster fruit fly species its superior ability to metabolize alcohol.

Using support vector machine recursive feature elimination, the researchers identified three gene expression signatures that predicted therapy responses.

When the team looked at what gene signatures the RORγt - dependent ILCs expressed, they found high expression of major histocompatibility complex class II (MHCII) protein, which some cells use to display foreign proteins to the immune system and directly interact with T cells.

Today, The New York Times reports that on Sunday Duke decided to halt enrollment in three clinical trials in which Potti and Duke's Joseph Nevins were using gene - expression signatures to predict a patient's response to chemotherapy.

«If we knock out, one by one, a wide range of genes of known function, and analyze proteins, metabolites and lipids, using the technology that Josh's group has developed, the data provide a «signature» for what each protein is doing.

Other biomarkers and genetic signatures are being used in an effort to predict the aggressiveness of an individual patient's prostate cancer, «but the current information doesn't make it possible for their gene signature to be an actual target for precision medicine targeted therapy,» Ellis explained.

Using «marker assisted breeding» that tracks the signature of water - efficiency genes, he has been able to accelerate the breeding of new drought tolerant chickpea varieties.

A team led by Pablo Tamayo and Jill Mesirov of the Broad Institute and University of California, San Diego, and Broad bioinformatician Arthur Liberzon, has generated «hallmark» gene sets from the Molecular Signatures Database (MSigDB), one of the most comprehensive and widely used databases for gene set enrichment analysis.

Using advanced high - throughput technology, the laboratory has developed gene signature profiles to help predict disease recurrence and response to medical therapies.

In the lead profile, Jansson represented those researchers investigating such diseases by using omics technologies - uncovering the DNA sequences, expressed genes, and metabolite signatures used to reveal links to microbial functions in the gut.

Next, they extracted the DNA from developing and mature heart cells, using an advanced gene - sequencing technique called ChIP - seq that lets scientists «see» the epigenetic signatures written in the DNA.

(b) Network constructed as in a using genes from the salmon, tan, blue and black modules all enriched for genes in the meditation signature.

In order to perform gene expression signal deconvolution we applied CIBERSORT35 v1.04 and the LM22 gene signature to all blood samples, using gene RPKMs, with default parameters, deconvoluting the signal into 22 different cell types.

In addition to the GSEA oncogenic signature database, we used the KEGG (Kyoto Encyclopedia of Genes and Genomes) database and published breast cancer metastasis data sets.

The cancer biology predictors were developed by taking gene lists from prominent papers in the literature and using them to generate signatures of tumor biology / microenvironment deregulation.

Intriguingly, our hBCSGs are mostly unrelated to cell cycle / mitosis genes and are distinct from the prognostic signatures currently used for stratifying BC patients.

LUMC offers an extended multiplex transcriptome profiling assay (dcRT - MLPA) for monitoring innate, adaptive and inflammatory immune - response signalling gene signatures, which can be used to evaluate and improve immunisation strategies.

Paris Descartes APHP and INSERM Poster # / Location: 4546 / Section 25, Board 1 Hyperlink: http://www.abstractsonline.com/pp8/#!/4562/presentation/7648 The tumor inflammation signature (TIS) and other gene expression signatures, simultaneously analyzed using the IO 360 panel, predict clinical benefit of anti-PD1 treatment (nivolumab and pembrolizumab) in «real life» patients with various cancer types, including NSCLC.

Here we compared the methane production between runnel and polygonal ponds using stable isotope ratios, 14C signatures, and investigated potential methanogenic communities through high - throughput sequencing archaeal 16S rRNA genes.