Leonard S. Schleifer, a neurologist and assistant professor at Columbia University, founded Regeneron in 1988 with the goal of
using gene technology to regenerate neurons.
This standard addresses health and safety requirements, regulating the sale of food produced
using gene technology, other than additives and processing aids.
Division 1 of this Standard sets out the permission and conditions for the sale and use of foods produced
using gene technology.
Division 2 of this Standard specifies the labelling and other information requirements for foods produced
using gene technology.
Not exact matches
The treatment (which involves injecting people with modified viruses carrying the CRISPR
technology that will go in and repair the faulty DNA) can be injected directly into the retina and, in this case,
used to delete the portion of the CEP290
gene that's responsible for the disease.
BOSTON, April 20 (Reuters)- Alnylam Pharmaceuticals Inc said on Friday that Dicerna Pharmaceuticals Inc will pay it $ 25 million in cash and stock to resolve a lawsuit claiming it stole trade secrets about
gene - silencing
technology used to develop drug treatments.
Editas, a startup based in Cambridge and founded in November 2013, wants to eventually
use the
technology to treat disease by coming up with therapies that can modify faulty disease - causing
genes.
For example, researchers could
use the
technology to replace a disease - causing mutated
gene with a healthy one.
The group's guidance follows calls for various bans on
use of the
technology known as CRISPR - Cas9, which has quickly become the preferred method of
gene editing in research labs because of its ease of
use compared with older techniques.
Well, one startup is seeking to take a very different approach: Exonics Therapeutics, which has secured $ 5 million in seed funding from CureDuchenne Ventures to see if the revolutionary new CRISPR - Cas - 9
gene - editing
technology can be
used to target the root genetic deficiency at the heart of the disease.
Companies are also finding that
using M&A to acquire R&D capabilities is an effective way to build positions in emerging
technologies such as
gene therapy and biosimilars.
By invalidating key parts of Myriad's patents, the court has removed a bar that prevented labs
using new
technology from developing and selling broader one - time tests that search for all known cancer risks, including the BRCA
genes, geneticists said.
But, as journalist Steve Connor reports, the reference to editing was intentional: «Scientists have
used the genome - editing
technology to cure adult laboratory mice of an inherited liver disease by correcting a single «letter» of the genetic alphabet which had been mutated in a vital
gene involved in liver metabolism.»
Before the products from these varieties can be
used, they will need approval from the Office of the
Gene Technology Regulator, which ensures GM plants are safe for humans and the environment and from Food Standards Australia and New Zealand which regulates food safety.
Using gene - sequencing
technology, researchers established that the precise segment of the pup's DNA «switched on» by the act of grooming was the part that controlled the future function of the hippocampus, which processes stress hormones.
BETTER BABIES If CRISPR / Cas9 or other
gene - editing
technologies are ever approved for
use in human embryos, parents may one day feel as if they have to
use genetic enhancements to give their children the best life possible.
Dr. Giedd's research team seeks to
use cutting edge
technologies to explore the relationship between
genes, brain and behavior in healthy development and in neuropsychiatric disorders of childhood onset.
«I fully support the reproductive
use of
gene - editing
technology for the prevention and elimination of serious genetic diseases,» Green said at the symposium.
A day after a critical patent ruling on the
gene - editing
technology called CRISPR, researchers gathered at the 2017 AAAS Annual Meeting to discuss the
technology's future ethical and regulatory concerns surrounding its broader
use.
It also may be possible in the future to repair the
gene mutation
using gene - editing
technology, which the investigators were able to do in the laboratory dish, he added.
«We spent half a dozen years trying to target the beta globin
gene using the old
technology,» he noted, adding that within one week of trying CRISPR, they had an editing tool that worked much better.
Brains of individuals who died with Huntington's, Parkinson's or no neurological condition were analyzed
using sequencing
technology that provides a data readout of the activity of all
genes in the genome.
Lu's team will extract immune cells called T cells from the blood of the enrolled patients, and then
use CRISPR — Cas9
technology — which pairs a molecular guide able to identify specific genetic sequences on a chromosome with an enzyme that can snip the chromosome at that spot — to knock out a
gene in the cells.
To identify
genes involved in the patterning of adult structures, Gal4 - UAS (upstream activating site)
technology was
used to visualize patterns of
gene expression directly in living flies.
In 1993, between the first and second years of his MBA program, Kreiner interned at Affymetrix, a then - new company that
used technology from the semiconductor industry to analyze vast numbers of
genes.
Next, the scientists removed the Duchenne mutations in the iPS cells
using a
gene editing platform they developed that
uses the CRISPR / Cas9
technology.
The scientists then scanned the samples
using microarray
technology, which cuts genetic material into segments to provide a snapshot of which
genes are active and which are asleep inside the cells.
Using the genomic
technologies he's learned at the IGB, Woolbright hopes to develop a research program that investigates climate - driven changes in species interactions at the
gene level.
A team of researchers at the University of Central Florida is
using breakthrough
gene - editing
technology to develop a new screening tool for Parkinson's disease, a debilitating degenerative disorder of the nervous system.
The
technology has been developed in recent years in fruit flies, mosquitoes and other organisms,
using CRISPR
gene editing.
Immune cells called CAR - T cells have already been engineered
using other
gene - editing
technologies.
To do this, they created a cellular model of Werner syndrome by
using a cutting - edge
gene - editing
technology to delete WRN
gene in human stem cells.
For his part, Collins, who has led NIH since 2009 and been kept on by the Trump administration, pointed to an array of promising NIH activities, including the development of new
technologies to provide insights into human brain circuitry and function through the Brain Research through Advancing Innovative Neuroethologies (BRAIN initiative) and the
use of the
gene - editing tool CRISPR - Cas9 to correct mutations and clear the way to develop and test a «curative therapy» for the first molecular disease: sickle cell disease.
Using a novel combination of
technologies, including trio exome sequencing of patient / parental DNA and genetic studies in the tiny larvae of zebrafish, the EuroEPINOMICS RES consortium found that mutations in the
gene CHD2 are responsible for a subset of epilepsy patients with symptoms similar to Dravet syndrome — a severe form of childhood epilepsy that is in many patients resistant to currently available anti-epileptic drugs.
Ultimately, this week's discourse will lead to a consensus statement providing some guidance on how to approach
using this and older
gene editing
technologies such as zinc finger nucleases and enzymes called transcription activator - like effector nucleases, or TALENs.
Both companies are also exploring RNA interference (RNAi)
technology — the
use of RNA molecules to inhibit
gene expression — to prevent plant diseases.
He
used a molecular
technology called ribo - tag that allowed him to find out which
genes were being made into proteins by astrocytes.
Today, biologists from Oregon report in Nature that they have had unprecedented successes
using that
gene - editing
technology to alter early - stage, viable human embryos.
In the case of CHD2, scientists collaborating with the EuroEPINOMICS RES consortium
used antisense
technology to rapidly generate zebrafish larvae with a partial loss of function of this
gene, and were then able to detect epileptic seizures in these animals
using electrographic analysis (this method is very similar to electroencephalography, or EEG, which is
used to analyze seizures in humans).
With the state - of - the - art DNA sequencing
technology used in this study, they will be able to pinpoint the exact mistake in each patient's SS - related
genes.
Last year, another group
used TALENs, an older
gene - editing
technology, to create two cows without horns, but this is the first time CRISPR has been reported to insert a
gene in cattle.
In the second stage of the study, the researchers
used another version of the
gene - probe
technology, called «quantitative PCR,» which yielded the vaginal concentrations of each of the 20 species in every sample, and linked it to HIV risk.
GenInfo is well organized and easy to «browse,» whether you need the new statement on cloning from the Human Genome Organization or the new Swedish law concerning the
use of
gene technology on human beings.
Using iPS cell
technology, the scientists found that only cells harboring the FOP
gene mutation would respond to Activin - A by significantly increasing their BMP signaling.
«What we
used to do in years, we can now achieve in months,» said
gene researcher and immunologist Klaus Rajewsky, indicating the power of this new genome - editing
technology.
Last year, another group
used TALENs, an older
gene - editing
technology, to create two cows without horns, but this is the first time scientists have reported
using CRISPR to insert a
gene in cattle.
«With this breakthrough we now have a working
technology whereby anyone can pass on their
genes to a child by
using just a few skin cells,» he says.
Using a powerful genetic
technology called RNA - seq, these experiments revealed a nearly comprehensive list of all the
genes, including some not previously identified, that guide the development of taste cells.
NIH scientists then searched for disease - causing
genes using next - generation DNA sequencing,
technology that allows researchers to sequence DNA quickly and economically.
«However, our new approach
uses cutting - edge DNA sequencing
technology to precisely measure the effects of thousands of sequences on
gene activity at the same time.»