Sentences with phrase «using genomic approaches»

As part of Plant Biology research at CSHL, scientists are using genomic approaches to understand everything from plant evolution to how plants grow, develop, and reproduce.

Areas of focus include: understanding how tumour - reactive T cells and B cells promote patient survival in cancer; defining the effects of standard treatments on tumor immunity; and using genomic approaches to identify novel tumour mutations that can serve as target antigens for immunotherapy.

Sarah and collaborators at OUCRU are also using a genomic approach to identify protective mechanisms of immunity to severe malaria as part of MalariaGEN Consortial Projects 1 and 2.

We are currently quantifying the genetic variability of this gene as well as other closely linked genes using a genomic approach.

Using genomics approaches, Dr. Nobrega has identified the gene IRX3 as the strongest association to polygenic obesity in humans, and characterized the mechanisms by which mutations altering the expression of a gene called TCF7L2 also represent the strongest genetic link to type 2 diabetes in humans.

Using a genomics approach, the lab is investigating the regulatory mechanisms behind accumulation of this important compound in different tomato varieties.

I primarily use genomic approaches to address these, and over the last few years my group has used large - scale population genomics to identify the global origin and routes of spread of many human and animal pathogens.

Not exact matches

But now «the approach can be reset using the bacterial and human genomic data,» says immunologist Steven Schutzer of the University of Medicine and Dentistry of New Jersey.

Castoe and his team used a similar genomic approach to understand gene flow in two closely related species of western rattlesnakes with an intertwined genetic history.

«Depending on the research questions, it may also be important to define the appropriate strategy to use, either whole - genome sequencing or just targeting some genomic regions with a gene baiting approach,» says Besnard.

«Using innovative data normalization and gene selection approaches, we combined the statistical power of multiple genomic studies and masked their variability and batch effects to identify robust early diagnostic biomarkers of pancreatic cancer,» said first author Manoj Bhasin, PhD, Co-Director of BIDMC's Genomics, Proteomics, Bioinformatics and Systems Biology Center and Assistant Professor of Medicine at HMS.

The researchers received another surprise when they used recently developed genomic approaches to compare the expression of genes related to calcification in coccolithophores grown under current and future seawater conditions.

To overcome the extreme genomic complexity, the team used new long - read sequencing technology that boosted the quality of the genome sequence obtained by more than one hundred fold over standard short - read approaches.

The work is the first time that a large - scale functional genomic approach has been used to systematically examine how bacteria can gain capabilities that improve their ability to colonize living organisms, in this case mice.

«While previous molecular studies have provided simple snapshots of the gene transcript variations that are associated with the exposure of insects to natural and synthetic chemicals, the genomics approaches used in this study offer a significantly more complex perspective on the biochemical and physiological processes occurring in plant - insect interactions,» Schuler said.

By analyzing the role of PPARγ in dendritic cells using molecular, genomic, and pharmacologic approaches, we identified genes and gene networks regulated by this receptor.

Identification of new pathological biomarkers for monogenic diseases using a functional genomic approach.

His group also uses novel genomics approaches to identify genes related to flavor and disease resistance.

Glass and his Venter Institute colleagues are now using synthetic biology and synthetic genomics approaches developed at the JCVI to create cells and organelles with redesigned genomes to make microbes that can produce biofuels, pharmaceuticals, and industrially valuable molecules.

2012 In this thesis, I investigate the genetics of neuropsychiatric disorders by analysing large data sets derived from high - throughput experiments, using novel comparative genomics approaches.

Chory and her team run a vertically integrated program, using genetics, genomics, cell biology, x-ray crystallography, biochemistry and ecological approaches.

The Parasite Genomics group uses comparative and functional genomics approaches to investigate the biology of helminths and protozoan parasites.

Currently, we are exploring several environmental samples retrieved from allover the world - ranging from hydrothermal vents in Japan to hot springs in Yellowstone National Park and New Zealand — for the presence of novel archaeal (and bacterial) lineages using cultivation - independent approaches, such as metagenomics and single cell genomics.

Disa will work on the genomic exploration of «microbial dark matter», focusing on new archaeal lineages and viruses, using both lab - and bioionformatics - based approaches.

He studies rare disease mutations and common heritable traits and disorders, such as fear - learning and autism, using mouse models as well as genomic and bioinformatic approaches.

To achieve these goals, his group uses a variety of organisms and experimental approaches, including mouse transgenesis, ES and TS cell culture, chick embryology, and comparative genomics.

She implemented these approaches in Bioconductor, an open source software program used with high - throughput genomic data.

Our main goal in this project is to use NGS in identification of genetic causes of rare / ultrarare early - onset neurologic diseases, integrating «omics» platforms with systematic approaches to enrich and redefine phenotypic ontology in these conditions, allowing a comprehensive analysis of genomic data.

«Especially in older individuals, but probably in all individuals, a good practice would be to... screen your iPSCs beforehand using a genomic or genetic approach so that you can screen out lines that might have a pathogenic variant,» Torkamani said.

The lab's goal is to develop computational approaches to study phenotype - genotype associations using the power of comparative and evolutionary genomics, followed by experimental verifications.

Steve's research focuses on polyploid crops where he uses genomics and bioinformatics approaches to examine chromatin structure and the effect it has on gene regulation.

We use various approaches including genetics, genomics and cell biology to study gene functions in normal development and disease such as cancer.

«Our goal is to use comparative genomics approaches to fill in gaps in our understanding of how plant reproduction works and to define the aspects of the mechanisms we've discovered so far that are either ancient or new innovations.»

Supervises wet lab, building amplicon, genomic and metagenomic libraries using various approaches to sequence on variety of platforms (illumina as well as PacBio) to study the understanding of the relationship between the microbiome and metabolic diseases.

Using the oral microbial community as a model system, we are applying functional genomic approaches including Stable Isotope Probing (SIP), metatrascriptomics and directed single cell genomic approaches to enable us to overcome this limitation.

In particular, I have initiated a team approach that is identifying and studying recurrent, treatment - refractory cancers in our clinics using these approaches as a component of evidence - based diagnostic medicine, seeking to better understand the genomic drivers in these cancers and to identify novel treatment approaches that target them, in hopes of obtaining durable responses.

Our team designed a mixed - methods approach, utilizing quantitative surveys and qualitative methods, to examine preferences and motivations of physicians and patients enrolled, evaluate the flow and utilization of genomic information within the clinical interactions, and assess understanding, behavior, medical consequences and healthcare costs associated with the use of WGS in these models of medical practice.

We are investigating these and other allied questions using evolutionary genomic approaches, by performing comparative analyses of plant genomes, transcriptomes and proteomes.

The NHGRI Intramural Health Disparities Postdoctoral Fellowship is intended to provide promising recent doctoral graduates the opportunity to use genetic and genomic approaches to advance the growing area of health disparities research.

The Cancer Genome Atlas is using genomic, transcriptomic, and epigenomic measurements of cancer cells, coupled with computational approaches and rich clinical data, to understand the dysfunctions that underline the onset, progression, and spread of cancer.

His research focuses on the use of genomic approaches to uncover the functional impact of human genetic variation, and especially its role in causing severe Mendelian diseases.

Economic Modeling: Our economic modeling core, led by Dr. Ann Wu, uses a variety of modeling approaches to project the medical and financial consequences of genomic medicine, including the use of pharmacogenomic testing to inform medication choices and the use of sequencing as an adjunct to standard newborn screening.

This section invites manuscripts describing (a) Linkage, association, substitution or positional mapping and epigenetic studies in any species; (b) Validation studies of candidate genes using genetically - engineered mutant model organisms; (c) Studies focused on epistatis and gene - environment interactions; (d) Analysis of the functional implications of genomic sequence variation and aim to attach physiological or pharmacogenomic relevance to alterations in genes or proteins; (e) Studies of DNA copy number variants, non-coding RNA, genome deletions, insertions, duplications and other single nucleotide polymorphisms and their relevance to physiology or pharmacology in humans or model organisms, in vitro or in vivo; and (f) Theoretical approaches to analysis of sequence variation.

Using integrated bioinformatics and genomics approaches to understand important traits of agricultural crops.

We use a combination of conditional mouse models, primary cell culture (human and mouse), live microscopy, highthroughput genomics and proteomics approaches, and basic molecular biology.

In this first - of - a-kind survey, researchers used a forward - looking approach to screen the genes that produce tyrosine kinases — reasoning that somewhere in this genomic landscape they might encounter novel mutations that spur colon cancer and other types of cancer.

Using a comprehensive integration of genomic and molecular approaches we will determine the biochemical context in which AR signaling drives breast cancer tumorigenesis.

Multiple genomics approaches are used to explore cancer biology.

As part of an ongoing functional genomic screening approach, we have been using microarray analysis and next generation sequencing to identify mouse genes that are specifically expressed in meiosis, and are likely involved in aspects of chromosome biology that are required for meiotic ploidy reduction.

We apply personalised functional genomics to study diseases in patient - derived cells using systematic and targeted approaches to unravel mechanisms and discover novel treatments (see video).