Sentences with phrase «using human adenoviruses»

Despite their popularity — several HIV vaccines are in development using human adenoviruses — the approach has a significant drawback.

Not exact matches

Adenovirus 5 has 50 or so known relatives that infect humans and so in principle could also be used as a basis for vaccines, as could one from a chimpanzee.

Chimp adenovirus vaccines may have an edge over those that use the human version, shown here in an electron micrograph (hexagon shapes).

We used the Virochip, a microarray designed to detect all viruses, to identify a new species of adenovirus (TMAdV, or titi monkey adenovirus) that caused a deadly outbreak in a colony of New World titi monkeys at the California National Primate Research Center (CNPRC), and also infected a human researcher.

Adenovirus PCR was performed on a TMAdV - positive clinical sample, a TMAdV culture, and a human adenovirus B culture (as a positive control) using an additional 5 pairs of primers, according to previously published protocols [26], [27], [28] Three of the 5 primer pairs, designed to detect human respiratory adenoviruses B, C, and E, failed to amplify TAdenovirus PCR was performed on a TMAdV - positive clinical sample, a TMAdV culture, and a human adenovirus B culture (as a positive control) using an additional 5 pairs of primers, according to previously published protocols [26], [27], [28] Three of the 5 primer pairs, designed to detect human respiratory adenoviruses B, C, and E, failed to amplify Tadenovirus B culture (as a positive control) using an additional 5 pairs of primers, according to previously published protocols [26], [27], [28] Three of the 5 primer pairs, designed to detect human respiratory adenoviruses B, C, and E, failed to amplify TMAdV [27].

Second, our results show that PCR assays for human adenoviruses in common use are capable of detecting TMAdV.

A defective adenovirus (one that can not grow or cause adenovirus infections in humans) is sometimes used as a vector in HIV vaccines.

Additional experiments using RNA isolated from stocks of viruses from different virus families showed no cross reactivity of the assay with influenza A virus, influenza B virus, rhinovirus, human coronaviruses 229E, OC43, and NL63, and adenovirus (data not shown).