Sentences with phrase «using human and mouse»

Scientists publishing in Nature Communications report that they have developed a mini working replica of the female reproductive tract using human and mouse tissue.

Not exact matches

It has been predicted already that by 2020, we will be using gesture control on computers to stop us using our mouse and keypad, and that there will be a rise in robotics carrying out human work in an office environment.

Currently SQZ is developing its technology further using mouse models and human blood experiments to understand its mechanisms of action more fully.

Of course, there is still a long way to go before this particular method will be tested on humans (it was tested on mice), and an even longer way to go before it'll be used in medical therapies (if it ever will translate into therapies), but one thing is becoming clear: We need not compromise our moral principles and rush into government - funded embryo - destructive research.

The researchers used specially born and raised mice having no gut microbes of their own, that then receive a transplant of 14 bacteria that normally grow in the human gut.

Data from experiments on phytic acid using mice and other rodents can not be applied to humans.

Hassles such as buying paper towels or searching for the perfect used car that used to require legwork, human interaction, and possibly even wearing pants can now be done with a click of a mouse from one's own living room.

Mice ranged in age from a few months to almost three years, monkeys from less than one year to 30 years, and humans from age zero to 86 years (cord blood was used to represent age zero).

He and some colleagues are already attempting to use human organoids to plug stomach holes in mice.

Shukla and colleagues discovered that a small drug molecule called BX795, which is sold to labs for use in experiments, helped clear HSV - 1 infection in cultured human corneal cells, in donated human corneas, and in the corneas of mice infected with HSV - 1.

The behavioral tests used here modeled one dimension of the disease — an inability to experience pleasure from normal activities — but not others, such as stress and anxiety, and probably tap into different brain mechanisms in mice than in humans, he says.

Duke scientists have shown that it's possible to pick out key changes in the genetic code between chimpanzees and humans and then visualize their respective contributions to early brain development by using mouse embryos.

Like the Rosetta Stone that scholars used to decode hieroglyphics, researchers trained the algorithm with more than 4,600 T cell receptors and then used it to correctly assign 81 percent of the human T cells and 78 percent of mouse T cells to one of 10 different viral epitopes.

Dr Luis Pedro Coelho, commented: «These findings suggest that dogs could be a better model for nutrition studies than pigs or mice and we could potentially use data from dogs to study the impact of diet on gut microbiota in humans, and humans could be a good model to study the nutrition of dogs.

Using the modified system, human melanoma and breast cancers as well as mouse melanoma cells were diagnosed with greater ease and efficiency.

«The mouse is one of the most utilised models for studying human biology and we use it for creating models of human illnesses and testing new drugs and therapies.

But it was another three decades before Klassen — who has used retinal progenitor cells to restore vision in mice, cats, dogs and pigs — could conduct human trials involving retinitis pigmentosa.

The UT Southwestern group had previously used CRISPR - Cas9, the original gene - editing system, to correct the Duchenne defect in a mouse model of the disease and in human cells.

Senior author Madhav Dhodapkar, M.D., the Arthur H. and Isabel Bunker Professor of Medicine and Immunobiology, and chief of Hematology, said the study, using tissue and blood samples from humans and mice, shows that chronic stimulation of the immune system by lipids made in the context of inflammation underlies the origins of at least a third of all myeloma cases.

Many universities and pharmaceutical companies are engaged in research and development using genetically modified mice that have certain genes manipulated to reproduce human diseases.

Part of the problem, he says, is that the incidence of many human chronic diseases rises with age, yet many researchers prefer using young mice because of the pressures of being published and getting funding.

Professor Chayama and his research group used mice with «humanized» livers, and injected them with human blood.

Using the new gene - editing enzyme CRISPR - Cpf1, researchers at UT Southwestern Medical Center have successfully corrected Duchenne muscular dystrophy in human cells and mice in the lab.

Currently, Deng's laboratory is conducting additional preclinical studies using the human - derived stem cells from Down syndrome patients and mouse models to determine whether cellular and behavioral abnormalities can be improved with minocycline therapy and other candidate drugs.

Already, researchers have used CRISPR / Cas9 to edit genes in human cells grown in lab dishes, monkeys (SN: 3/8/14, p. 7), dogs (SN: 11/28/15, p. 16), mice and pigs (SN: 11/14/15, p. 6), yeast, fruit flies, the worm Caenorhabditis elegans, zebrafish, tobacco and rice.

While mouse models have traditionally been used in studying the genetic disorder, Deng said the animal model is inadequate because the human brain is more complicated, and much of that complexity arises from astroglia cells, the star - shaped cells that play an important role in the physical structure of the brain as well as in the transmission of nerve impulses.

In the current work, they used a new variation of the gene - editing system to repair the defect in both a mouse model and in human cells.

In their study, Stephanie Cherqui, PhD, associate professor in the UC San Diego School of Medicine Department of Pediatrics, and colleagues used a transgenic mouse model that expresses two mutant human FXN transgenes, and exhibits the resulting progressive neurological degeneration and muscle weakness.

Anatomical examination of human and mouse eyes was used to determine the effect of the laser on the sensitive light - detecting retina.

HeLa allowed researchers to study polio, measles, papilloma virus (HPV), HIV and tuberculosis; it was used to create the first human - mouse cell hybrid, and even sent into space.

Using the supercomputers at Almaden and Lawrence Livermore National Laboratory, the group simulated networks that crudely approximated the brains of mice, rats, cats and humans.

All animals use the same enzyme to create the same methylation mark as a signal for gene repression, and her colleagues who study epigenetics in mice and humans are excited about the new findings, Strome said.

Using a mouse model of HSV - 1 as well as autopsied samples of human adult and fetal tissues, investigators from Dartmouth College's Geisel School of Medicine found that antibodies against HSV - 1 produced by adult women or female mice could travel to the nervous systems of their yet unborn babies, preventing the development and spread of infection during birth.

The mice were examined with ultrasound echocardiography before and after the three - month treatment period — using metrics closely paralleling those used in humans.

Microbeads coated in a human egg protein work as a contraceptive in mice and could also be used to select the best sperm for IVF

They injected the particles directly into mice with an experimental human brain cancer, and into the brains of healthy mice for use as comparison.

Since the current work was done in mice, O'Leary and Zembrzycki want to confirm the link in humans by using brain scans to measure the natural variation in the neocortical areas and search for potential links to disease.

If the drug is deemed safe and the role of Oprl1 in humans mimics that seen in mice, Ressler would move toward testing how it could be used to prevent PTSD.

The researchers used «humanized mice,» which have had their immune systems replaced with human immune system cells, thymus tissue and bone marrow.

The group has already started tweaking human iPS cells using the same genes that Saitou pinpointed as being important in mouse germ - cell development, but both Saitou and Hayashi know that human signalling networks are different from those in mice.

The results obtained by Afsaneh Gaillard's team and that Pierre Vanderhaeghen at the Institute of Interdisciplinary Research in Human and Molecular Biology show, for the first time, using mice, that pluripotent stem cells differentiated into cortical neurons make it possible to reestablish damaged adult cortical circuits, both neuroanatomically and functionally.

«These two studies highlight the value of using an integrated multi-systems approach — including fruit flies, mice, and human cells — to discover mechanisms underlying disease processes.»

Most animal studies of the disease are conducted with laboratory mice that have been genetically engineered and bred to model ALS, but for this research, investigators used rats with ALS because they more accurately portray the disease's variable course in humans.

Starting in the mid-2000s, Yoshiki Sasai's team at the RIKEN Center for Developmental Biology in Kobe, Japan, demonstrated how to grow brainlike structures using embryonic stem cells, first from mice and then humans.

IVF has long been used in humans, mice and other mammals.

But little is known about the early developmental stages of human gametes — owing to the sensitivity of working with human tissue — and most work in this area has been conducted using mice.

We can use clues from similarities with the mouse and human genomes.

The dosages used in human executions are, in some cases, lower by body weight than the dosages that would kill only 50 percent of mice and from which monkeys have been able to successfully recover.

Researchers developed a new type of cell transplantation to treat mice mimicking a rare lung disease that one day could be used to treat this and other human lung diseases caused by dysfunctional immune cells.

In the new study, Lipton and his colleagues used human stem cell and mouse models to show exactly how SNO can trigger cell death in Parkinson's disease.