Sentences with phrase «using human cancer cell»

Using human cancer cell lines helps, but the crucial interplay between the cancers and their host environments is absent.

In studies using human cancer cell lines, a new, never - described compound known as BMH - 21 destroyed this critical communication pathway.

(NaturalHealth365) Consumers already concerned about vaccine dangers are likely to find little reassurance in recent reports that Food and Drug Administration (FDA) officials are giving vaccine manufacturers the green light to use human cancer cells to produce future vaccines.

Not exact matches

Available epidemiologic studies in humans have «not shown clear evidence of a relationship between cell phone use and cancer,» according to the National Cancer Institute, although this remains a topic of debate among researcancer,» according to the National Cancer Institute, although this remains a topic of debate among researCancer Institute, although this remains a topic of debate among researchers.

This technique has been used, as Arnold reports, to trace the progress of cancers, advance our understanding of obesity and diabetes, and prove that brain cells continue to form through a human being's lifetime.

Using the modified system, human melanoma and breast cancers as well as mouse melanoma cells were diagnosed with greater ease and efficiency.

Using this biosensor in highly invasive breast cancer cells taken from rodents and humans, the Einstein team discovered that when an individual invadopodium forms and is actively degrading the ECM, its Rac1 levels are low; on the other hand, elevated Rac1 levels coincide with the invadopodium's disappearance.

A DEVICE that filters cancer cells from human blood using sound could help to identify tumour cells that have spread.

The stem cells, derived from human umbilical cord - blood and coaxed into an embryonic - like state, were grown without the conventional use of viruses, which can mutate genes and initiate cancers, according to the scientists.

Using both fruit fly and human lung cancer cell lines, researchers targeted two of the most common genetic mutations associated with NSCLC — Ras and PTEN (P13K).

Human chondrosarcoma HCS - 2 / 8 cells, which are a type of benign bone cancer cells, can be used to investigate how optimization of culture conditions could improve the synthesis of cartilage - specific molecules.»

To see whether cancer stem cell renewal involves a chain of events similar to that used by embryonic stem cells, and whether the process was affected by oxygen levels, Semenza and graduate student Chuanzhao Zhang focused their studies on two human breast cancer cell lines that responded to low oxygen by ramping up production of the protein ALKBH5, which removes methyl groups from mRNAs.

Exploiting the same pre-clinical model used for their studies, the researchers are testing the efficacy of this kind of drug candidates against cancer stem cells, and the possibility of identifying combination regimens with standard chemotherapies with minimized toxic effects, with the perspective of their possible application for the treatment of human breast cancer.

Using in vitro, or test tube, experiments, the researchers applied these chemicals to human cancer cells to measure changes of estrogen receptor - and androgen receptor - target genes and transcriptional activity.

In research published in BioMetals, UJ3 is shown to be as effective against human esophageal cancer cells, as a widely - used chemotherapy drug in use today.

The use of bone marrow - derived stem cells is well established in the treatment of human cancer patients, and veterinary applications for bone marrow - and adipose - derived stem cells are being evaluated.

A team of researchers in Germany and Denmark led by Steven Johnsen, Professor at the University Medical Center Göttingen, Germany, used human prostate cancer cell lines and depleted them of the DNA - binding protein CHD1.

By using molecular genetic tools to reduce the amount of PC in human lung cancer cells, the team observed decreased cell growth, a compromised ability to form colonies in soft agar (a gelatinous material specifically used to grow bacteria and other cells), and a reduced rate of tumor growth in mice.

In preclinical experiments using human prostate cancer cell lines, Fu's team showed that increased PLK1 expression activated an oncogene known as c - RAF, which has previously been shown to play a role in regulating cell growth and division.

In the lab, the scientific team used an approach that combined functional RNAi analysis with gene expression analysis in breast cancer - derived cell lines and in human breast cancers replicated in mice.

Over the past two years, investigators from the Perelman School of Medicine at the University of Pennsylvania have reported results from a human trial in GBM using chimeric antigen receptor (CAR) T cell therapy, through which patients» own T cells were engineered to track down and kill cancer cells that express a tumor - specific protein known as EGFRvIII.

The existence of cancer stem cells has already been reported in a number of human cancers, explains Professor Jacobsen, but previous findings have remained controversial since the lab tests used to establish the identity of cancer stem cells have been shown to be unreliable and, in any case, do not reflect the «real situation» in an intact tumour in a patient.

«If further studies validate that these processes are critical in human breast cancers,» Koshy notes, «the possibility exists that agents that favorably modify the biophysical properties of the extracellular matrix, or that target the receptors and signaling molecules associated with how cells sense this matrix, could be used as a new avenue for the prevention or treatment of breast cancers.»

The transplantation of isolated human hematopoietic stem cells is used in the treatment of anemia, immune deficiencies and other diseases, including cancer.

In human medicine EGFR is frequently used as the target of cancer immunotherapy because many cancer cells bear this receptor on their surface.

The results of this original study are highly relevant to other human diseases that dependent on genome instability, such as fungal infection or cancer, and open new venues for anti-leishmanial drug discovery using host - directed strategies that target the parasite's metabolic dependence on the host cell, thus preventing the adaptive evolution of drug resistant parasites.

The goal of the first experiment was to see whether lncRNAs are differentially expressed in prostate cancer by measuring total RNA from prostate cancer cell lines and normal epithelial prostatic cells using NCode human ncRNA array and SurePrint G3 human lncRNA microarrays.

This means that these devices have the potential to be used in the human body in the future in applications such as drug delivery and locating cancer cells.

The human genome contains around 20,000 genes, by refining CRISPR - Cas9 technology and using it to screen the leukemia genome the team uncovered a catalogue of approximately 500 genes that are essential for cancer cell survival, including more than 200 genes for which drugs could be designed.

They have also used AAV gene editing to introduce naturally occurring cancer - causing mutations into the endogenous allele of the STAG2 tumor suppressor in human cells -LRB-

They have also used AAV gene editing to introduce naturally occurring cancer - causing mutations into the endogenous allele of the STAG2 tumor suppressor in human cells (Kim et al, 2016).

Nagrath, who directs Rice's Laboratory for Systems Biology of Human Diseases, found that some cancer cells are capable of using these information packets as a source of energy to fuel tumor growth.

Many human enzymes use the metal to catalyze important reactions, but cancer cells seem to need it more than healthy cells.

The analysis of doxorubicin resistance in human breast cancer cells using antibody microarrays.

We chose this model because 1) it more closely recapitulates features of human pancreatic cancer than do s.c. - implanted tumors, 2) it can be used in immunocompetent mice to permit assessment of immune responses, and 3) the cells grow in vivo with predictable kinetics (34).

The critical roles of tumor - initiating cells and the lymph node stromal microenvironment in human colorectal cancer extranodal metastasis using a unique humanized orthotopic mouse model.

seek to identify the mutational processes underlying mutational signatures found in cancers, characterise the mutational processes operating in normal cells, use phylogenetic analyses of somatic mutations in humans to explore cellular lineages during embryonic development

We use 3D stem cell («organoid») cultures from mice and humans to examine occurrence, level and molecular causes of CIN in cancer (Video 2).

The study used three cell types: human motor neurons derived from induced pluripotent stem cells, rat cortical cultures, and human breast cancer cells.

Using cutting - edge techniques enabled by next - generation sequencing, the authors generated complete methylome maps at single nucleotide resolution in a low - passage breast cancer cell line and normal breast tissue (primary human mammary epithelial cells).

The answers they have discovered so far reveal critical information about gene regulation; specifically, that cells are used to record the positional identity in human tissues, and that the «perturbation,» the disturbance, of such programs plays a major role in cancer progression, especially in metastasis, whereby cancer cells spread to other parts of the body.

And we can also use what we know about the genetics of the human cancer to make mutations in normal cells, and see how different mutations drive invasion.»

A major focus of their current cancer research is using animal, cell - based, molecular, and biophysical approaches to investigate the role of HIF - 1 in vascular and lymphatic metastasis of human breast cancer.

Conditions for hypoxia / reoxygenation cycles were optimized using two human metastatic breast cancer cell lines (MDA - MB 231 and BCM2).

• Patients must have adequate coagulation (international normalized ratio (INR) or prothrombin time (PT), partial thromboplastin time (PTT) ≤ 1.5 times ULN) • Adequate liver function (total bilirubin ≤ 1.5 times the ULN, alanine aminotransferase (ALT) and aspartate aminotransferase (AST) ≤ 2.5 times ULN Exclusion Criteria: • Presence of active / uncontrolled central nervous system involvement • History of clinically significant cardiac disease; uncontrolled hypertension • Left ventricular ejection fraction (LVEF) < 45 % • Allogeneic stem cell transplant within 100 days before first dose of study drug • Known history of human immunodeficiency virus (HIV) infection • Chronic or active hepatitis B or C, requiring antiviral therapy • Evidence of history of bleeding disorder, dialysis, or coexisting cancer that is distinct in primary site or histology from the cancer evaluated in this study • Serious, uncontrolled infection • Unresolved chronic toxicity > grade 1 from prior therapy • Use of strong CYP3A4 inhibitors or strong inducers within 7 days prior to the start of study treatment and for the duration of the study

51) Drost, J., van Boxtel, R., Blokzijl, F., Mizutani, T., Sasaki, N., Sasselli, V., de Ligt, J., Behjati, S., Grolleman, J.E., van Wezel, T., Nik - Zainal, S., Kuiper, R.P., Cuppen, E., and Clevers, H. Use of CRISPR - modified human stem cell organoids to study the origin of mutational signatures in cancer.

Using RNA interference (RNAi), first author Richard Possemato targeted these genes in human breast cancer cells implanted in mice.

I was trying to understand how pancreatic cancer spreads (metastasises) to lymph nodes, using human cells and mice to model the process in the lab.

canSAR contains information on the entire human proteome — the protein equivalent of the human genome - as well as linking to information on more than 1,000 cancer cells lines, used by researchers to study the effect of new drugs in the lab.

The first UK license for CRISPR / Cas9 use in editing genes in human embryos was granted in 2016, xvii and CRISPR - edited cells to treat lung cancer were administered in the world's first human trials for the technique by a Chinese group in late 2016.