Using human cancer cell lines helps, but the crucial interplay between the cancers and their host environments is absent.
In studies
using human cancer cell lines, a new, never - described compound known as BMH - 21 destroyed this critical communication pathway.
Not exact matches
Using both fruit fly and
human lung
cancer cell lines, researchers targeted two of the most common genetic mutations associated with NSCLC — Ras and PTEN (P13K).
To see whether
cancer stem
cell renewal involves a chain of events similar to that
used by embryonic stem
cells, and whether the process was affected by oxygen levels, Semenza and graduate student Chuanzhao Zhang focused their studies on two
human breast
cancer cell lines that responded to low oxygen by ramping up production of the protein ALKBH5, which removes methyl groups from mRNAs.
A team of researchers in Germany and Denmark led by Steven Johnsen, Professor at the University Medical Center Göttingen, Germany,
used human prostate
cancer cell lines and depleted them of the DNA - binding protein CHD1.
In preclinical experiments
using human prostate
cancer cell lines, Fu's team showed that increased PLK1 expression activated an oncogene known as c - RAF, which has previously been shown to play a role in regulating
cell growth and division.
In the lab, the scientific team
used an approach that combined functional RNAi analysis with gene expression analysis in breast
cancer - derived
cell lines and in
human breast
cancers replicated in mice.
The goal of the first experiment was to see whether lncRNAs are differentially expressed in prostate
cancer by measuring total RNA from prostate
cancer cell lines and normal epithelial prostatic
cells using NCode
human ncRNA array and SurePrint G3
human lncRNA microarrays.
Using cutting - edge techniques enabled by next - generation sequencing, the authors generated complete methylome maps at single nucleotide resolution in a low - passage breast
cancer cell line and normal breast tissue (primary
human mammary epithelial
cells).
Conditions for hypoxia / reoxygenation cycles were optimized
using two
human metastatic breast
cancer cell lines (MDA - MB 231 and BCM2).
canSAR contains information on the entire
human proteome — the protein equivalent of the
human genome - as well as linking to information on more than 1,000
cancer cells lines,
used by researchers to study the effect of new drugs in the lab.