Sentences with phrase «using human oocytes»
Outline title: «First live birth using human oocytes reconstituted by spindle nuclear transfer for mitochondrial DNA mutation causing Leigh syndrome» by J. Zhang et al. published in outline form by the American Society of Reproductive Medicine's Fertility and Sterility journal website.
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Mindful of public sensitivities, Daley opted to pursue experiments using what he considers the least controversial human materials to create new nonpresidential stem cell lines — poor quality embryos and oocytes that, in his words, «otherwise would have been disposed of as medical waste.»
To do this, they used a nanotemplate of known stoichiometry (the human Glycine receptor expressed in Xenopus oocytes) and studied several fluorescent proteins to see the percentage of proteins that was photoactivated.
«The idea will be to obtain oocytes and discarded embryos from IVF treatments in order to test this technology using human samples.»
«The use of nonhuman oocytes for SCNT is currently the only ethically justifiable option given the large numbers of eggs required to derive cloned human stem cell lines,» he said.
While many important developments impacted the field, two that garnered significant public, political and scientific attention in 2016 were the proliferation of clinics using unproven stem cell «therapies,» and the steps forward in therapeutic modification of human oocytes (unfertilized eggs) through a process called mitochondrial replacement therapy (MRT).
As outlined below, we used a microfluidic quantitative PCR (qPCR) system to elucidate the gene expression profiles of individual human oocytes and small numbers of cumulus cells using a combination of a large number of samples and targets [12], and then extended our studies via the use of parthenogenesis, in conjunction with gene expression profiling, as a functional assay of cytoplasmic maturation of oocytes.
Ms. Roxland concurrently served as the Special Advisor to the Commissioner of Health on Stem Cell Research Ethics, where she spearheaded creation of state - wide rules on embryonic stem cell protocols, human - animal chimera research, compensation of women who donate their oocytes to stem cell research, informed consent processes, re-contact for return of research results and incidental findings, and downstream uses of biological samples.