Sentences with phrase «using laboratory mice»

Using laboratory mouse models of inflammatory and neuropathic pain, they showed that the antibody can target the Nav1.7 channel and reduce the pain sensation in these mice.

Not exact matches

But, as journalist Steve Connor reports, the reference to editing was intentional: «Scientists have used the genome - editing technology to cure adult laboratory mice of an inherited liver disease by correcting a single «letter» of the genetic alphabet which had been mutated in a vital gene involved in liver metabolism.»

This study identifies myomerger as a fundmentally required protein for muscle development using cell culture and laboratory mouse models.

The result is a repulsive effect, which was used by Yuanming Liu and colleagues at the Jet Propulsion Laboratory in Pasadena, California, to lift a young mouse weighing 10 grams.

Aside from a food intake in laboratory mice that's about 40 percent fewer calories than normal, however, it's been found that another way to activate this pathway is with rapamycin, which appears to have a significant impact even when used late in life.

Currently, Deng's laboratory is conducting additional preclinical studies using the human - derived stem cells from Down syndrome patients and mouse models to determine whether cellular and behavioral abnormalities can be improved with minocycline therapy and other candidate drugs.

Now, in a new study using laboratory - grown cells and mice, Johns Hopkins scientists report that a method they used to track metabolic pathways heavily favored by cancer cells provides scientific evidence for combining anti-cancer drugs, including one in a nanoparticle format developed at Johns Hopkins, that specifically target those pathways.

Using the supercomputers at Almaden and Lawrence Livermore National Laboratory, the group simulated networks that crudely approximated the brains of mice, rats, cats and humans.

In this study, published in the October 31 issue of the Proceedings of the National Academy of Sciences, Sudhir Yadav PhD, a neuroimmunology post-doctoral fellow in the laboratories of Drs. Kouichi Ito, associate professor of neurology, and Suhayl Dhib - Jalbut, professor and chair of neurology, tested mice that were engineered to have a pre-disposition for MS. Because mice would not normally develop MS, researchers used MS - associated risk genes from real patients to genetically engineer mice for this study.

Most animal studies of the disease are conducted with laboratory mice that have been genetically engineered and bred to model ALS, but for this research, investigators used rats with ALS because they more accurately portray the disease's variable course in humans.

Critics postulated that mouse DNA was floating in the air in the laboratories, or lying in wait in the chemical reagents used to find the virus, or sitting at the bottoms of test tubes used to collect blood specimens.

In 2005, Rudolf Jaenisch's laboratory at Whitehead reported preliminary success with this strategy, using mouse cells.

The scientists are able to use tissue not only from laboratory mouse models, but also from human patients.

The laboratory's Oncology Preclinical Services team, which offers preclinical efficacy studies using PDX and other models, including humanized (hu)- NSG mice, is also under his direction.

In the Rutgers study, Zong and lead author Ji - An Pan, a scientist in his laboratory, looked at liver and heart damage in laboratory mice and found that the mice in which the TRIM21 gene was inactivated suffered little heart or liver damage when put through the same laboratory procedures used to produce tissue damage in mice with the gene.

For example, it could be used to image neurons in living mice by combining the Raman scattering technique with existing methods in which tiny windows are implanted in the brains and spinal cords of laboratory animals.

Prusiner, together with Fred Cohen and his colleagues, also at UCSF, and Ruth Gabizon at Hadassah University Hospital in Israel, used human prions to infect a special strain of laboratory mice.

Researchers in the Cedars - Sinai Samuel Oschin Comprehensive Cancer Institute eradicated solid tumors in laboratory mice using a novel combination of two targeted agents.

Even small children might be surprised to discover that their representatives in Washington no longer consider rats, mice, and birds used in laboratory experiments to be animals, or at least animals worthy of protection.

Now, the Laboratory of Malaria Immunology Team at the Immunology Frontier Research Center (IFReC), Osaka University, headed by Professor Cevayir COBAN, have used mouse malaria models to show that robust immune activation and invasion of parasite by - products into the bone marrow during and after malaria infection leads to an adverse balance in bone homeostasis - a process usually tightly controlled - by bone forming osteoblasts and bone resorbing osteoclasts.

Laboratory mouse models are commonly used to study A-T; however, mice with A-T do not experience the more debilitating effects that humans do.

«The mutation prevention system maintained antibiotic sensitivity not only in E. coli strains cultured in standard laboratory conditions but also in bacteria that were used to colonize the gastrointestinal tract of gnotobiotic mice.

The researchers note that more work and evaluation is needed for definitive results, and they hope to improve and expand upon the method of using natural microbiomes in laboratory mice.

That's because most studies on single human brain cells use dead rather than living tissue, and many others rely on cells from common laboratory animals, especially mice.

C57BL / 6 wild - type mice (The Jackson Laboratory, 000664; n = 8) were used as an additional control for comparison purposes, but were not included in any statistical analyses.

About 25 million mice are used in laboratories around the world to test new drugs and new notions about the biochemical machinery of living organisms.

But while most PDX mice are used as general models of human cancer in the laboratory, others seek to use them as Fiebig originally hoped — as avatars to guide customized patient care.

Since Dolly, several university laboratories and companies have used various modifications of the nuclear transfer technique to produce cloned mammals, including cows, pigs, monkeys, mice and Noah.

Researchers in China have discovered how to use mouse stem cells to grow mouse sperm in laboratory settings.

Caribou granted The Jackson Laboratory (JAX) non-exclusive, worldwide rights to use Caribou's CRISPR - Cas9 intellectual property to create genetically engineered mice for research purposes in 2016.

Finally, Dr. Goldenring's laboratory is also investigating the role of Rab25 as a tumor suppressor in the colon using the Rab25 - / -; Smad3 + / - mouse model, which develops spontaneous invasive distal colon cancers.

In the Finkbeiner laboratory, Linsley uses time - lapse imaging of neurons in culture, within organotypic mouse brain slices, and within live zebrafish to uncover the mechanisms in neurodegeneration that lead to neuronal death.

Yasuaki Tamura, working with colleagues in the laboratory of Pramod Srivastava, demonstrates that tumor - derived heat shock protein - peptide vaccines can be used to treat a wide array of pre-existing tumors in mice.

In the paper, published May 6, 2015 in Nature, the scientists report using these new stem cells to develop the first reliable method for integrating human stem cells into nonviable mouse embryos in a laboratory dish in such a way that the human cells began to differentiate into early - stage tissues.

Using cell culture and laboratory mouse experiments, the researchers showed that the enzyme, aldose reductase, is essential to a process known as goblet cell metaplasia that is seen in both asthma and COPD.

A team of Chinese and American researchers led by Dr. Ji - jing Pang of the Eye Hospital, School of Ophthalmology and Optometry, Wenzhou Medical College, Wenzhou, PR China, and including Jackson Laboratory scientist Bo Chang, M.D., used gene therapy to restore cone function in the retinas of the B6 (A)- Rpe65rd12 / J (005379) mouse, a model of Leber congenital amaurosis — even if the disease has progressed for three months (Li et al. 2011; Pang et al. 2005).

In his laboratory mice, Dr. Ding has now used chemical reprogramming to turn fibroblasts into neural «precursor» cells with the potential to become new oligodendrocytes.

Researchers at the MDI Biological Laboratory have been using animal models beyond the well - known laboratory mouse foLaboratory have been using animal models beyond the well - known laboratory mouse folaboratory mouse for decades.

U.S. Senators Susan Collins and Angus King, Congressman Bruce Poliquin, LePage administration Senior Policy Advisor John Butera and Ellsworth Mayor Robert Crosthwaite were on hand to launch the new facility, which is the first step in the Laboratory's long - range plan to gradually migrate mouse production (except for the research mice used by JAX scientists) from Bar Harbor to Ellsworth, freeing up space in Bar Harbor to expand research and education programs.

In 2012 she joined the laboratory of Dr. D.L. Konotyiannis at BSRC AL.Fleming, Greece as postdoctoral scientist, where she worked on the study of the RNA Binding Protein HuR during intestinal and lung inflammation and cancer, using inducible, KO and Tg mouse models and xenografts.

Akassoglou's laboratory uses mouse models of blood - driven neural inflammation and autoimmunity to explore further the role of fibrinogen in MS, and she is now pursuing similar lines of investigation on other neurological diseases.

The Jackson Laboratory's Rare and Orphan Disease Center in Bar Harbor is creating mouse models with Talia's very rare genetic disorder in the hopes that scientists can use the mice to find a treatment for the disorder.

The study focused on embryonal rhabdomyosarcoma caused by mutations in the Sonic Hedgehog signaling pathway and used a mouse model developed in Hatley's laboratory.

Procedures involving mice were approved and performed following the guidelines of the Institutional Animal Care and Use Committee (IACUC) of Duke University Division of Laboratory Animal Resources (DLAR).

Laboratory Animal Genetic Services (LAGS) provides MD Anderson investigators with cost - effective, customized genome scans using polymorphic genetic markers to support rapid congenic line development and background strain characterization for mice and rats.

These unique 3 - D reconstructions of mouse olfactory cells, which govern the sense of smell, were obtained using X-ray imaging tools at the Department of Energy's Lawrence Berkeley National Laboratory (Berkeley Lab).

Another recent study from Xiao - Jiang Li's laboratory at Emory University used a similar (but not exactly the same) technique to remove huntingtin in mice at 2, 4, and 8 months of age.

In my laboratory, we use mouse models to investigate HSC function, disease development and in vivo mutagenesis.

Food and liquid intake measurements are recorded using patented algorithmic load cell technology as applied to behavioral research models of laboratory mice, rats and NHPs.

The dual appointment allows him to conduct experiments that compare genetic programming in the highly regenerative animals used as models at the MDI Biological Laboratory with genetic programming in neonatal and adult mice.