Sentences with phrase «using molecular approaches»

In this study, we used a molecular approach to identify...

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«Using a new approach of combining molecular identification of the SPIKE gene and conventional breeding, we have developed rice, with the SPIKE gene, that has higher yield when compared with an equivalent rice without the gene,» Dr. Kobayashi said.

In a recent publication in ACS Nano, Reilly and Ingber developed this method by combining computer animation software approaches from the entertainment industry with rigorous molecular dynamics simulation tools commonly used in biological research.

In the future, studies are aimed at using novel molecular approaches to selectively delete AMPK in specific brain regions associated with nicotine dependence to better understand the functional role of this protein in addiction.

By using a combination of advanced genetics, molecular approaches, and microscopy techniques, they found that this signaling pathway is used in the adult brain in a completely novel way.

«We think we can use our molecular, rational design approaches to make a better flu vaccine for people who really need it,» says study leader Andrew Pekosz, PhD, an associate professor in the Department of Molecular Microbiology and Immunology at the Bloomberg School of Publimolecular, rational design approaches to make a better flu vaccine for people who really need it,» says study leader Andrew Pekosz, PhD, an associate professor in the Department of Molecular Microbiology and Immunology at the Bloomberg School of PubliMolecular Microbiology and Immunology at the Bloomberg School of Public Health.

Earlier, for his Ph.D., he used his physics training to study biological interactions at the molecular resolution — but for his postdoc he changed approaches dramatically, turning to cell biology and applying his skills to the development of high - resolution functional imaging of DNA transcription in living cells.

The advantage of Novavax's approach is that a vaccine can be made rapidly and in high volume, compared with the egg - based approach that's used today, says Ted Ross, an associate professor of microbiology and molecular genetics at the University of Pittsburgh's Center for Vaccine Research (CVR).

Molecular biologist Venter recently used this approach to create what he calls the first synthetic organism.

UCLA chemists and molecular biologists have for the first time used a «structure - based» approach to drug design to identify compounds with the potential to delay or treat Alzheimer's disease, and possibly Parkinson's, Lou Gehrig's disease and other degenerative disorders.

A team of chemists from the University of Wisconsin - Madison has introduced a new fuel cell catalyst approach that uses a molecular catalyst system instead of solid catalysts.

We've used modern molecular approaches to characterize the vaginal microbiome and link specific bacteria to HIV acquisition risk in young women living in Sub-Saharan Africa, where HIV is most profound,» says first author Christina Gosmann, a postdoctoral research fellow at the Ragon Institute of MGH, MIT and Harvard.

In a study published July 15 in ACS Central Science, a team of chemists from the University of Wisconsin - Madison introduces a new approach that uses a molecular catalyst system instead of solid catalysts.

Gilbert and colleagues took students and their teachers into the field and used inquiry - based learning to teach molecular and field approaches to ecology, as well as foster an international pipeline to ecological research.

A biologist, Schaal was among the first plant scientists to use molecular biology - based approaches to understand evolutionary processes in plants and she has worked to advance understanding of plants» molecular systems and population genetics.

Dr. Lu's team used a biochemical approach combined with MRI to detect molecular changes that signal micrometastases.

His laboratory uses a multidisciplinary approach encompassing systems biology, molecular pharmacology, biochemistry / proteomics, cell and structural biology, and computation / bioinformatics.

While various molecular biology techniques were initially used to identify and validate epigenetics enzymes and their substrates, novel approaches are now available to perform pharmacological characterization of histone - modifying enzymes.

His current research uses a variety of molecular, biochemical, and genetic approaches to study the basic biology of mesenchymal stem cells (MSCs).

There are ongoing studies which focus on the discovery of molecular biomarkers of the VSV - ZEBOV vaccine in healthy individuals using omics - based technologies in combination with a systems biology approach,» says Ali Harandi.

The researchers Fabrício Carvalho and Fernando Mantelatto from the Laboratory of Bioecology and Crustacean Systematics at University of São Paulo and Célio Magalhães from Instituto Nacional de Pesquisas da Amazônia therefore used a combined molecular and morphological approach aiming to resolve this issue.

The new approach makes use of molecular fragments administered alongside antimicrobial agents.

In this study, the researchers used molecular, cell biological, in vivo genetic and bioinformatics approaches to identify the EGFR ligand amphiregulin as a physiological substrate, and demonstrate a role for iRhoms in amphiregulin - EGFR - dependent wound healing.

To resolve the picture of the chemosensory array, Schulten and his colleagues used molecular dynamic flexible fitting, a computer modeling approach Schulten's lab developed at Illinois.

She was accepted as a doctoral student there and began a research career in which she was among the first plant scientists to use molecular biology - based approaches to understand evolutionary processes in plants.

Gijs van der Schot, a Ph.D. student in the Department of Cell and Molecular Biology at Uppsala, will describe the researchers» new approach to imaging during the AVS 62nd International Symposium & Exhibition, held Oct. 18 - 23 in San Jose, Calif. «The X-ray laser we use for our work, the LCLS, is a fascinating machine — because of the physical principles behind it and the precise engineering of its parts — that produces very bright and ultra-short pulses,» he said.

Li takes an unconventional approach in his research and applies molecular genetics, such as the use of DNA, to the field of organizational psychology.

«While previous molecular studies have provided simple snapshots of the gene transcript variations that are associated with the exposure of insects to natural and synthetic chemicals, the genomics approaches used in this study offer a significantly more complex perspective on the biochemical and physiological processes occurring in plant - insect interactions,» Schuler said.

Muzykantov, who has developed other approaches for using red blood cells as molecular vehicles, says the significance of the new method «exceeds just drug delivery.»

The project, which brings together physical oceanographers, marine biologists, imaging specialists, molecular biologists, bioinformaticists and modelers, uses what it calls a «holistic» and «study it all» approach, analyzing many species at once using a variety of methods, many of them automated.

His group has pioneered the use of transcriptomics and — more recently — metabolomics approaches for stress signaling applications with relevance to molecular toxicology.

Daniel Packwood, Junior Associate Professor at Kyoto University's Institute for Integrated Cell - Material Sciences (iCeMS), is improving methods for constructing tiny «nanomaterials» using a «bottom - up» approach called «molecular self - assembly.»

«This «molecular can - opener» approach — using a drug known to have a useful action without exactly knowing why — allowed us to examine and understand an underlying pathogenesis of bipolar disorder,» said Snyder.

Using this approach, these investigators found that nodes (genes) with high connectivity tend to have lower levels of change in expression than peripheral nodes, consistent with the notion that disease ‐ causing genes are typically not central hubs in a molecular module.

The structural information is used for the rational design and development of small molecular inhibitors in combination with chemical biology approaches.

«Many current approaches use nanoparticles to deliver RNAi drugs into cells,» said Steven F. Dowdy, PhD, professor in the Department of Cellular and Molecular Medicine and the study's principal investigator.

Using a combination of molecular biology, biochemical and novel multi-dimensional digital imaging approaches we study in real - time complex multi dimensional signal integration during the interaction of T cells with live antigen - presenting cells.

By analyzing the role of PPARγ in dendritic cells using molecular, genomic, and pharmacologic approaches, we identified genes and gene networks regulated by this receptor.

Claire is currently a PhD candidate in the Molecular and Cellular Biology Program at the University of Washington, where she studies the patterning and development of the nervous system, using genetic and bioinformatic approaches.

Researchers aim to answer these questions using cutting - edge electron microscopy techniques in combination with molecular and biochemical approaches.

Dr. Sonntag studies this concept on the molecular and cellular level using a translational research approach that integrates the analysis of human material, such as postmortem brains, primary cell systems, and neural cell populations generated from patients» - or healthy individuals» - derived induced pluripotent stem cells (iPSC), or induced neurons (iNs), in combination with molecular, biochemistry, and lentivirus - mediated gene - engineering technologies.

The hypothesis was tested using an integrative approach at the isolated organ, cellular and molecular levels, in a longitudinal study in rats.

A large variety of methods is used including genetic, molecular and cytogenetic techniques, fluorescence in situ hybridisation and DNA «combing», as well as high throughput sequencing approaches such as DNA - seq for mutation landscape analyses, RNA - seq for transcriptome analyses and ChIP - seq mapping of chromatin - associated proteins and their genome - wide modulation in response to DNA damages.

Key climate - relevant biogeochemical processes such as calcification, primary production and nitrogen fixation are investigated using a large array of techniques, ranging from molecular tools to physiological and ecological approaches.

Mike Alexander, Alex Laskin, Yuri Desyaterik, and John Ortega, who work at DOE's Environmental Molecular Sciences Laboratory (EMSL) at PNNL and Xiao - ying Yu of PNNL's Atmospheric Science and Global Change Division, collected an extensive set of measurements of aerosol mass, size distribution, composition, and particle morphology using an array of in - situ techniques and aerosol sampling approaches.

Contributions that use cellular and molecular approaches to shed light on mechanisms of physiological control at higher levels of organization also appear regularly.

Using single - molecule imaging, super-resolution microscopy and various biophysical and molecular approaches she will explore how gene expression in living cells works.»

11:30 Maximilian Menger: Excited state gradients in polarizable QM / MM models: an induced dipole formulation 11:50 Alireza Marefat Khah: Molecular gradients of polarizable Embedded RI - CC2 12:10 Daniele Loco: A QM / MM approach using the AMOEBA polarizable embedding: from ground state energies to electronic excitations

In an interdisciplinary approach, the team will first systematically identify genes that are required for this differentiation process - information which will then be used to investigate their molecular mode of action, their targets, and if and how they interact with each other.

The subsequent pharmacophore approaches used for further molecular - size reduction led to the identification of cyclic pentapeptides containing these indispensable amino acids.