Not exact matches
Empliciti will be
used in combination with two other drugs to treat
patients with multiple
myeloma who have received one to three prior courses of medication.
Researchers
used tissue and blood samples to show that the gammopathy (a precursor to
myeloma) in both mice and
patients with Gaucher disease is triggered by specific lipids, and that the antibodies made by tumor cells in nearly a third of
myeloma patients are directed against such lipids.
Whether investigating fat cells, immunotherapy or
use of the CRISPR - Cas 9 gene - editing tool, which a federal panel recently approved for a select number of
patients suffering from three types of cancers, including multiple
myeloma, approaches beyond attacking cancer cells are needed in the fight against many cancers.
Researchers at MIT have now shown that they can
use a new type of measurement to predict how drugs will affect cancer cells taken from multiple -
myeloma patients.
Results from a clinical trial investigating a new T cell receptor (TCR) therapy that
uses a person's own immune system to recognize and destroy cancer cells demonstrated a clinical response in 80 percent of multiple
myeloma patients with advanced disease after undergoing autologous stem cell transplants (ASCT).
«Despite current drugs and
use of bone marrow transplantation, multiple
myeloma is still incurable, and almost all
patients eventually relapse,» says co-principal investigator and multiple
myeloma specialist Craig Hofmeister, MD, MPH, assistant professor of medicine and a member of the OSUCCC — James Translational Therapeutics Program.
Plerixafor has been approved by the FDA as the first small - molecule CXCR4 antagonist for
use in combination with granulocyte - colony stimulating factor (GCSF) to mobilize hematopoietic stem cells to the bloodstream for collection and subsequent autologous transplantation in
patients with non-Hodgkin's lymphoma and multiple
myeloma.
Instead, newer trials have suggested that the
use of minimal residual disease (MRD) status may be a valid surrogate outcomes for survival in
patients with
myeloma who achieved CR.