Three studies diagnosed diabetes from a 75 - g
oral -
glucose -
tolerance test (6, 21, 23), 3 from fasting plasma
glucose concentrations (11, 22, 24), and one study
used postload or fasting
glucose concentrations (10).
Compared to ad libitum fed controls, rodents maintained on IER (100 % ER / alternate days) for periods of 12 to 24 weeks typically exhibit lower post-treatment levels of fasting
glucose 14, 16, 17, 29 and insulin.16, 17, 29
Using this particular IER protocol, Jiang et al28 have also demonstrated an increase in oral glucose tolerance and tissue insulin sensitivity (measured using a hyperinsulinemic - euglycemic clamp) after four weeks in healthy
Using this particular IER protocol, Jiang et al28 have also demonstrated an increase in
oral glucose tolerance and tissue insulin sensitivity (measured
using a hyperinsulinemic - euglycemic clamp) after four weeks in healthy
using a hyperinsulinemic - euglycemic clamp) after four weeks in healthy rats.