Sentences with phrase «using phages»

There is considerable interest in using phages as diagnostics and therapeutics of multi-drug resistant (MDR) bacteria.

For example, the food industry is already using these phages to destroy pathogens in food products by natural methods.

But using the phages, Nugen and his colleagues skipped this step and found the cells within a few hours.

Fischetti and his colleagues used a phage - encoded molecule to identify a bacterial target enzyme called 2 - epimerase, which is used by Bacillus anthracis to synthesize an essential cell wall structure.

In 1998, Sulakvelidze helped found the biotech company Intralytix, which has successfully devised a number of food safety products, including a spray that uses phages to eradicate Listeria, Salmonella and E. coli in foods before they reach stores.

John suggested to Fred that he use the phage as the training wheels for learning how to sequence DNA.

Another student who was using phage - display technology to identify new molecular markers in ovarian cancer attended a clinic in gynecologic oncology once a week throughout her dissertation research.

Phil Ross: There was a novel way back, written by Sinclair Lewis, I think Arrowsmith, where — this is in the 1920s before antibiotics were invented — where his scientist hero tries to use phages to... as a way of killing up bacteria to save people's lives, and that was an actual research project, which has come back now that bacteria are in many cases immune to antibiotics.

Together with CSL we embarked on a collaborative project aiming to identify novel antibodies to target melanoma cells using phage display technology.

After the last coffee break Emmanuelle Charpentier (Umeå University, Sweden) entered the scene and shared her knowledge about how to use phages (viruses that target bacteria) for genome engineering via CRISPRs.

Young worked with fellow researchers across the country to use phage treatment to save the life of Dr. Tom Patterson, a professor at UC San Diego School of Medicine, who while on a trip to Egypt became infected with a multi-resistant strain of Acinetobacter baumannii, a deadly pathogen.

: Also — We can also use phages, too.

Dr. Justin Marchegiani: Also — We can also use phages, too.

Not exact matches

It's developing a machine - learning algorithm that uses data from the genomes of both phages and bacteria.

As a result, phage therapy is now used only for the sickest patients, as a treatment of last resort.

Eventually, Merril sees an AI app being used in hospitals in combination with a dispensing system that could identify the most effective phage or combination of phages and distribute a vial to treat a patient within minutes.

AmpliPhi and Adaptive Phage Therapeutics have successfully treated more than two dozen patients with life - threatening conditions and are currently treating a few others under an emergency use authorization granted by the US Food and Drug Administration.

The company currently uses a lab test that takes a minimum of eight hours, and sometimes up to a day or two, to get a readout of what phage or phages will work best against a particular strain of bacteria.

For now, Adaptive Phage Therapeutics plans to use the AI system at its Maryland office to determine the best course of treatment for a patient, choose the right phage from its collection, and send the phage to the hospPhage Therapeutics plans to use the AI system at its Maryland office to determine the best course of treatment for a patient, choose the right phage from its collection, and send the phage to the hospphage from its collection, and send the phage to the hospphage to the hospital.

Phages identify and grab bacteria using proteins on their leglike tail fibers, which form a strong bond with compounds on the bacterial cell surface.

Once the phages latched onto the bacteria, researchers could use a magnet to round the bacteria up even before the bacteria ruptured and announced their presence.

The researchers embedded phages into soluble «sugar glasses» or films made with pullulan, a polysaccharide used to prolong the shelf life of fruits and eggs; trehalose, a sugar used as stabilizing agent in freeze drying; or a combination of two substances.

This is good news, because phage could be used as alternative treatment when antibiotics become resistant to pathogenic bacteria.

«Phage have been used as an alternative to antibiotics for decades in eastern European countries, particularly for treatment of urinary tract infections,» said corresponding author Catherine Putonti, PhD, Associate Professor of Bioinformatics, Loyola University, Chicago.

We use viruses called phages that infect bacteria but not human cells.

So - called phage therapy is widely used in Eastern Europe and is currently undergoing one U.S. clinical trial.

Somehow, the tiny phages sneaked in and overpowered the much larger cholera cells, using a big chunk of this stolen immune system.

Phages are still routinely used in Eastern Europe and, more recently, in Asia.

Leverentz says that her preliminary tests indicate phages may even find use one day in sanitizing counters, cutting boards, and kitchen utensils.

And thats one reason that we use a cocktail of different ones, she says — because its unlikely the bugs will quickly develop resistance to more than one phage.

Phages were used for more than 75 years as therapy in Eastern Europe, but they fell out of favour in the western world when antibiotics were discovered.

She explained that phages outnumber their bacterial prey by a factor of 10 to 1, and that they have been proposed as the agents of change in recipients of faecal microbiota transplantations used to treat resistant or recurring bowel disease.

A new technique of direct binding of radioactive DNA was used to screen a complementary DNA expression library from the BJAB cell line in lambda gt11 phage to derive molecular cDNA clones representing a putative B lymphocyte - specific octamer binding protein.

CRISPR - Cas normally uses its recorded sequences to detect and cut the DNA of incoming phages.

And then, using data collected by other scientists on three predator - prey pairs — mink - muskrat, gyrfalcon - rock ptarmigan and phage - Vibrio cholerae — they show how their theory could explain unexpected population cycles.

Some phages break out using an enzyme that digests the cell wall.

But Hatfull says there are plenty of other, yet - unstudied phages whose strategies could be adapted for use in antibiotics.

The work was published recently in the journal Applied and Environmental Microbiology and is part of the PhD thesis with international mention by Joan Colom Comas entitled «Studies of the Molecular features of Three Salmonella Phages for Use in Phage Therapy and of Encapsulation Methodologies to Improve Oral Phage Administration.»

To overcome these limitations, researchers developed a nanoencapsulation system using liposome capsules and applied them to the three aforementioned virulent bacteriophages in order to compare the effects of liposome - encapsulated phages and nonencapsulated phages on the concentration of Salmonella in model broiler chickens experimentally contaminated with the bacteria.

Using this new method, however, the scientists were able to simply reprogram such integrative phages so that they become interesting again for antibacterial applications.

The methodology developed allows encapsulating bacteriophages of different sizes and morphologies, demonstrates the advantages of using encapsulated bacteriophages for oral phage therapy and, moreover, the nanometric size allows adding it to potable water and fodder.

Nevertheless, in this research two limitations were observed in the use of orally administered bacteriophages: the reduced stability of the phages in extremely acid environments, such as the stomach, and short residence time in the intestinal tract.

The technology developed could be applied to bacteriophages with different morphologies to be used in phage therapy, in both animals and humans.

«To solve this problem, we borrowed a tool from phages themselves: the enzymes these viruses use to break apart a phage - infected cell to release their progeny,» says Douglas Deutsch, a graduate student in the lab.

The CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) system was originally discovered by dairy industry researchers seeking to prevent phages, the viruses that infect bacteria, from ruining the cultures used to make cheese and yogurt.

Bacteria incorporate small bits of DNA from phages into their CRISPR region and use that information to fight off the phages by chewing up their DNA.

Since current phagehunting procedures of Mycobacterium phages all use identical plating conditions, we would like to explore alternative phagehunting procedures to determine if that affects the type of phages isolated.

With the use of careful phage isolation procedures and environmental samples from various locations, such as alternative media usage and modified plaque - picking methods, we isolated potentially novel phages.

These phage libraries have tremendous diversity, so you can use them to find very unique antibody protein sequences that target specific molecules within disease pathways,» says Coyle.

Around the same time that transgenic mice began to be used to produce human antibodies, scientists also started employing a genomic technology called phage display to build massive libraries of human antibody genes that could be screened quickly.»