Sentences with phrase «using small molecules»

The scientists report that the next step is to identify this cell - to cell signal and attempt to block it using small molecules.

Then for postdoctoral research I moved to Yale University, where I worked in a lab that looked at all kinds of different disease areas using the approaches of a field called chemical biology, which is using small molecules — chemicals — to probe biological systems in the hopes of developing compounds that could be new drugs.

Schreiber is a world leader in chemistry, using small molecules as probes in uncovering biological functions.

With the invention, development, and commercialization of biologics, we moved from a blanket approach (treating many diseases using small molecules) to the use of more specific biologics with fewer off - target effects.

We found that link using small molecules, which means that we now have the tools in hand to suppress what cancer has coopted.

To make the findings more relevant to patients, they are also examining direct cellular conversion strategies using small molecules and other non-viral methods.

«This study is the first to show that we can successfully manipulate genome engineering using small molecules.

«Eventually you have to replace those genes with small molecules, with proteins, with whatever,» says Ding, who is working on cellular reprogramming methods that use small molecules, rather than viruses.

In a novel animal study design that mimicked human clinical trials, researchers at University of California, San Diego School of Medicine report that long - term treatment using a small molecule drug that reduces activity of the brain's stress circuitry significantly reduces Alzheimer's disease (AD) neuropathology and prevents onset of cognitive impairment in a mouse model of the neurodegenerative condition.

«Our findings for this study provide important starting points for using small molecule imaging techniques to explore MAO - B further at the organism level, and in fact, opens up future prospects for non-invasive imaging - based diagnostic applications,» said Dr Li Lin, the first author of the paper and a post-doctoral fellow in Prof Yao's lab.

By using a small molecule called 2 - bromo - palmitate (2BP) that inhibits these palmitate - adding enzymes, the researchers surmise that cancer patients might be able to one day make their cells more sensitive to cancer - fighting EGFR inhibitors.

The OHSU team discovered a way to use small molecules that enter cells, fix the misfolded proteins and allow the proteins to move to the correct place and function normally again.

UIC researchers, led by Asrar Malik, Schweppe Family Distinguished Professor and head of pharmacology, found they could trigger the cell - tightening mechanism in mice using a small molecule, called Fg4497.

Probing the catalytic functions of Bub1 kinase using the small molecule inhibitors BAY - 320 and BAY - 524.

«Instead of taking skin cells back to their stem cell - like beginnings, we used small molecules to take them only part way,» explains Dr. Ding.

Writing in the February 23 issue of Nature, the team revealed they had once again used small molecules to effect a near - complete cellular transformation.

Recently, Shaw's lab showed that using a small molecule to target one of the pathways that cells use to synthesize fat can starve cancer cells of the building blocks they need to grow.

«Using a small molecule to significantly boost and overcome limitations of the TRAIL pathway appears to be a promising way to address difficult to treat cancers using a safe mechanism already used in those with a normal effective immune system.

In 1996, Schreiber used small molecules to characterize the molecular nature of histone deacetylases (HDACs) for the first time — before this work, HDAC proteins had not been successfully isolated.

Using a small molecule such as a siderophore against bacterial infections is itself a novel approach, Mobley notes.

Bacteria use small molecule chemicals to mediate these interactions and the genetic information required for their production is typically encoded in one physical location of the bacterial chromosome, in biosynthetic gene clusters (BGCs).

«The idea of using a small molecule, like auxin, to rescue a protein - protein interaction is new in the pharmaceutical industry,» says Zheng.

To this end, we made use of two widely used small molecule inhibitors, PD98059 and SB203580.

The investigations are frequently combined with large scale perturbation methods, including gene - based (RNAi, miss - expression of wild type and mutant genes) and chemical approaches using small molecule libraries.

Chemical genomics involves interrogating cancer biology using small molecule probes.

The researchers used a small molecule called 2 - deoxyglucose, or 2DG, to block glucose metabolism and produce a ketogenic state in rats.

Not exact matches

Breakthrough: IBM has simulated the electronic structure of a small molecule, using a seven - qubit quantum computer.

«We could apply the strategy used in this study to quickly identify and design small molecule drugs for other RNA - associated diseases,» explained study first author Sai Velagapudi, a research associate in the Disney lab.

In their ACS Central Science study, Disney and his colleagues used DNA sequencing to evaluate thousands of small molecules as potential drug candidates.

To use fructose for energy, the body needs to convert it into another type of simple sugar called glucose or into other smaller molecules.

«We have discovered a small molecule compound that shows a profound and prolonged effect on autism - like social deficits without obvious side effects, while many currently used compounds for treating a variety of psychiatric diseases have failed to exhibit the therapeutic efficacy for this core symptom of autism,» said Zhen Yan, PhD, professor in the Department of Physiology and Biophysics in the Jacobs School of Medicine and Biomedical Sciences at UB, and senior author on the paper.

Shukla and colleagues discovered that a small drug molecule called BX795, which is sold to labs for use in experiments, helped clear HSV - 1 infection in cultured human corneal cells, in donated human corneas, and in the corneas of mice infected with HSV - 1.

«Most of what we are all doing with liquid biopsies is dealing with very small numbers [of molecules], so using a poor sample extraction or nonoptimized kit can really get rid of a lot of the signal,» she says.

«We are very excited about the prospect of using these more physiologically relevant cell - based models for gene and small molecule drug discoveries,» says Dr. Andrew Liu, Assistant Professor of Biology at the University of Memphis.

These models are amenable to high throughput drug screening and could be used to find promising small molecules to resynchronize or help body clocks function normally.

Still eager to make an MIS - like contraceptive for all women that is cheap and easy to use, perhaps as a pill, the researchers are searching libraries of small molecules to find one that mimics the action of MIS.

Using small - molecule inhibitors to eliminate the activity of the proteins produced by the bird - specific, median signaling zone in chicken embryos, the researchers were able to induce the ancestral molecular activity and the ancestral anatomy.

«Two big advantages to the small - molecule catalysts we've developed are that they are very general — they can work on many different amino acid and peptide structures — and they are very easy to use.

Using computer simulations to predict which drug candidates offer the greatest potential has thus far not been very reliable, because both small drug - like molecules and the amino acids of proteins vary so much in their chemistry.

One of the most important early applications will be to study the chemistry of small molecules or simple reactions, by using quantum computers to simulate the quantum mechanics of chemical systems.

Already, large companies such as DuPont are harnessing synthetic biology, and small companies «are being built around the idea of using organisms, designing organisms, using tools of synthetic biology to make molecules that can't be produced any other way,» Glass says.

Alpha and beta amylase enzymes found in malted barley (also found in your mouth and small intestine) are used to break down the starch present in the kernel into maltose and maltotriose, which are chains of two or three linear glucose molecules, respectively.

Unpublished results from the researchers hint that significantly fewer anomalies are seen in iPS cells created via virus - free reprogramming strategies, such as ones that use proteins or small - molecule drugs.

Focusing on antibiotics that have been used to counter infectious disease of humans, Walsh provides an up - to - date analysis of how these small molecules interfere with crucial processes in bacteria.

Our team is currently developing methods that can be used to screen small molecule inhibitors of EDD1 and also looking into how the regulation of TIP60 levels can be translated into therapeutic advances for the treatment of viral - mediated cancers such as cervical cancer.

We don't need to use a cocktail of small molecules, growth factors or other supplements to create a population of bone cells from human pluripotent stem cells like induced pluripotent stem cells,» Varghese said.

NMR, meanwhile, allows researchers to study biological molecules in a solution, such as water — but its use has generally been limited to relatively small proteins.

They demonstrated that their machine could build 14 different classes of small molecules, including ones with difficult - to - manufacture ring structures, all using the same automated building - block assembly.

Down the line, they hope their investigations will lead surgeons to use global small molecule urinalysis as an adjunct to the standard radiologic workup of patients with incidental adrenalomas.

Everything from cells to cedar trees is knit together using a myriad of weaker links between small molecules.