Sentences with phrase «using whole genome sequencing»

The agency noticed an increase in one rare DNA fingerprint of listeria popping up in the system in August, and, using whole genome sequencing technology, discovered that four other DNA fingerprints were also closely related genetically and possibly connected to infections that were reported five years ago.

Kp isolated from screening swabs and clinical diagnostic samples were characterized using whole genome sequencing and combined with epidemiological data to identify likely transmission events.

They are also looking for genes, that contribute to cancer progression using whole genome sequencing or a method called exome sequencing which they developed with Greg Hannon to look at mutations in the regions of the genome that code for proteins.

Using whole genome sequencing, the researchers discovered 228 different strains of E. coli in this collection.

Now, in a series of recent studies, scientists at the University of Missouri are using whole genome sequencing through the 99 Lives Cat Genome Sequencing Consortium to identify genetic variants that cause rare diseases, such as progressive retinal atrophy and Niemann - Pick type 1, a fatal disorder in domestic cats.

To confirm and strengthen the findings, Zwick and his team are currently performing an independent study of individuals with Down syndrome, using whole genome sequencing to further delineate alterations in genes that perturb heart development in children.

Using whole genome sequencing technology, researchers from The Netherlands have now succeeded in determining that at least 6.5 % of de novo mutations occur during the development of the child (post-zygotic) rather than from the germline of a parent.

«Researchers who aren't using whole genome sequencing to find off - target effects may be missing potentially important mutations,» Dr. Tsang says.

We carried out detailed genetic studies and used whole genome sequencing to look at every part of the DNA at diagnosis, and every part of the DNA at relapse,» says Dr. Dick.

In another study representing the first time precision medicine has been applied to feline health, Lyons and her team used whole genome sequencing and the 99 Lives consortium to identify a lysosomal disorder in a 36 - week - old silver tabby kitten that was referred to the MU Veterinary Health Center.

The team used whole genome sequencing techniques to compare the genetic information from the TB bacteria of each patient.

The St. Jude study is apparently the first to use whole genome sequencing to explore the contribution of genetics to lifetime cancer risk in survivors.

Further, we intend to use whole genome sequencing data from Leonardo's remains to better understand his extraordinary talents and visual acuity through genetic associations.

Now, as technologies have further evolved, the Broad's Center for Common Disease Genomics, together with other NHGRI centers, will seek to use whole genome sequencing to create a comprehensive catalog of the genetic variation associated with disease.

We are eager to use whole genome sequencing to identify the mutations responsible for other heritable canine diseases.

Not exact matches

«We hope our findings will encourage others to use whole - genome sequencing as a method to determine all the off - target effects of their CRISPR techniques and study different versions for the safest, most accurate editing,» Dr. Tsang says.

Using advanced sequencing technologies, University of Oklahoma anthropologists demonstrate that human DNA can be significantly enriched from dental calculus (calcified dental plaque) enabling the reconstruction of whole mitochondrial genomes for maternal ancestry analysis — an alternative to skeletal remains in ancient DNA investigations of human ancestry.

Whole - genome sequencing was used to study the differences in some of the major ethnolinguistic groups in the country.

Two study aims were to use novel whole - genome sequence data to (1) study possible correlations between language groups and genetic clustering, and (2) investigate the ancestral compositions of these individuals, including maternal and paternal lineages.

«Studies like the current one involving rhabdomyosarcoma are giving us a close - up look at the way cancer evolves in response to treatment,» said study co-author Richard K. Wilson, Ph.D., director of The Genome Institute at Washington University School of Medicine in St. Louis, where scientists have extensive expertise analyzing tumor recurrence using whole - genome sequeGenome Institute at Washington University School of Medicine in St. Louis, where scientists have extensive expertise analyzing tumor recurrence using whole - genome sequegenome sequencing.

Hur added, «To investigate whether Cpf1 had off - target effects, we performed whole genome sequencing using genomic DNA isolated from one Foxn1 mutant mouse and its wild - type sibling.

With more work, the technique could be used to sequence millions of longer DNA strands in parallel, slashing the cost of sequencing a whole mammalian genome.

They digested human genomic DNA using Cas9 nucleases in a test tube, which was then subjected by whole genome sequencing.

«Depending on the research questions, it may also be important to define the appropriate strategy to use, either whole - genome sequencing or just targeting some genomic regions with a gene baiting approach,» says Besnard.

Biofilm samples were frozen onsite, and subsequently processed and carried forward to pair - ended 150bp read length whole - genome sequencing (WGS) shotgun using Illumina HiSeq - 4000.

Users upload a patient's whole genome or exome sequence via a web - based interface, and the sequence is analyzed and filtered using various computational tools and databases of disease - causing mutations.

The research groups then examined the landscape of the pancreatic cancer epigenome using a combination of stains on patient tissues, direct examination of the proteins that wrap DNA and whole - genome sequencing of the detected epigenetic changes to map precisely where they were located.

Described in the January 7th issue of Neuron, the technique uses «deep,» highly sensitive whole - genome sequencing of single neurons and a new technology that identifies inserted bits of DNA caused by retrotransposons, one of several kinds of so - called somatic mutations that can arise as the brain develops.

Whole genome sequencing (WGS), which is the process of determining an organism's complete DNA sequence, can be used to identify DNA anomalies that cause disease.

Gardy's team used whole - genome sequencing to track the outbreak, an approach they pioneered four years ago when analyzing TB outbreaks.

The use of whole genome sequencing enables researchers to accurately distinguish between tumour types with different treatment strategies.

The study was performed using single stem cells cultivated to provide sufficient DNA for whole genome sequencing.

Using high - throughput sequencing of whole genomes will also be key in finding other kinds of genetic variation involved in autism, Grice explained.

Using whole - genome sequencing, they looked at rare genetic variants in modern - day British populations and compared them with variants in the DNA of 10 ancient skeletons.

This is one of the first population genomics analyses to use high - coverage whole - genome sequencing in pigs, each individual has been sequenced more than 20-fold depth with the genome coverage of 95 %.

In this study, researchers collected a Chinese alligator sample from Changxing Yinjiabian Chinese Alligator Nature Reserve (Zhejiang Province, China) and sequenced its genome using a whole - genome shotgun strategy.

Using technologies like whole genome or whole exome (the protein - coding portion of the genome) sequencing requires specialized equipment and advanced data analysis and is still relatively expensive.

Whole - genome fetal sequencing is still years away from being used in the real world.

Researchers investigated the glycophorin area of the genome in more detail than before using new whole - genome sequence data from 765 volunteers in the Gambia, Burkina Faso, Cameroon and Tanzania.

«The use of whole genome sequencing and the sheer number of samples we collected gave us a detailed picture of how the var gene repertoire changes continuously within red blood cells.»

Prenatal whole - genome sequencing will provide volumes of information beyond the currently available tests for genetic disorders such as Down's syndrome or Tay - Sachs disease — assays that parents now use to decide how to respond to a pregnancy.

Using a technique called whole - genome random sequencing, a TIGR team mapped the entire two - million - gene sequence of Thermotoga maritima, a bacterium first plucked from hot geothermal springs in Vulcano, Italy.

Using «homologous recombination,» CRISPR can also be used to insert new DNA sequences or even whole genes into the genome in a precise way.

Together with the French gene sequencing center Genoscope, in the Paris suburb of Evry, Celera will perform the initial sequencing using the «whole - genome shotgun» approach it unleashed on the human genome.

Using whole exome sequencing (a next generation test to analyze the exons or coding regions of thousands of genes simultaneously) conducted at the Baylor College of Medicine Human Genome Sequencing Center, the researchers identified CLP1 mutations in two unrelated families with thesequencing (a next generation test to analyze the exons or coding regions of thousands of genes simultaneously) conducted at the Baylor College of Medicine Human Genome Sequencing Center, the researchers identified CLP1 mutations in two unrelated families with theSequencing Center, the researchers identified CLP1 mutations in two unrelated families with the disorder.

In this study, researchers sequenced the whole genome of an Amur tiger, also known as the Siberian tiger, and assembled it using BGI self - developed software SOAPdenovo.

Using whole - genome sequencing, they found that immune cells needed this «key» to become specialised T helper cells.

They then comprehensively analyzed the changes in the whole genome and epigenome using next generation deep sequencing.

NJ trees were constructed for the whole - genome SNP set using the ape R package46 using distance matrices based on the metric of sequence divergence from Gronau et al. 25.

With the availability of genome sequences from representative species in whole phyla, rigorous quantitative measurements of genetic distance based on DNA sequence divergence has been used to test existing evolutionary trees and to re-classify organisms in all kingdoms.