Sentences with phrase «using young mice»

Part of the problem, he says, is that the incidence of many human chronic diseases rises with age, yet many researchers prefer using young mice because of the pressures of being published and getting funding.

Since most grants are usually only for a four - to five - year period, using younger mice is not only less expensive, but it avoids the delay of waiting for an animal to age.

Not exact matches

Call me unambitious but I will always say the league cup is not worth the hassle, its I Micky mouse cup that should only be used to test young players I didn't want us to win it against Chelsea or Birmingham I fact I was partly cheering for the bromies we should be focusing on the league and maybe the F.A cup.

They began by adding one of three commonly used sweeteners — saccharin, sucralose or aspartame — to the drinking water of healthy young mice.

The result is a repulsive effect, which was used by Yuanming Liu and colleagues at the Jet Propulsion Laboratory in Pasadena, California, to lift a young mouse weighing 10 grams.

Using a surgical technique called parabiosis to join the circulatory system of a young mouse with that of an old one, the researchers studied the effects of young blood on elderly cells, and vice versa.

To answer this question, Ding decided to use a cousin of the Flock house virus — Nodamura virus — that is lethal to young mice.

This visual abstract represents the findings of Thevaranjan et al. who, using young and old germ - free and conventional mice, demonstrate that age - related microbiota changes drive intestinal permeability, age - associated inflammation, and decreased macrophage function.

Changes in muscle repair with aging were determined by injecting the old mice and young mice (neither group exercised) with snake venom commonly used to induce muscle injury in rodent studies.

Samantha de Silva and colleagues used a viral vector to express a light sensitive protein, melanopsin, in the residual retinal cells in mice which were blind from retinitis pigmentosa, the most common cause of blindness in young people.

The researchers harvested satellite cells from both healthy and injured muscle tissue of young mice and from healthy tissue of old mice; extracted these cells» DNA with the histone coatings intact; and used tagged antibodies targeting the different kinds of marks to find which spots on those histones were flagged with either «stop» or «go» signals.

Bottom Line: Young mice that received molecularly targeted therapies used to treat brain cancer in human patients sustained cognitive and behavioral deficits, but the deficits were largely reversible through environmental stimulation and physical exercise.

Using a technique called parabiosis, in which the vascular systems of two mice are surgically connected, Villeda's lab had previously discovered that infusing old mice with the blood of younger mice leads to brain rejuvenation, including improvements in learning and memory, while infusions of old blood cause premature brain aging in young mice.

To find out if the loss of Tet2 in aging could directly cause cognitive decline, the researchers used a technique called RNAi to block Tet2 activity in the hippocampi of young adult mice.

Using young and aged transgenic mice and human - derived induced pluripotent stem cells, she will examine the effect of Alzheimer's - related mutations on translation and protein expression.

Defining the range of pathogens susceptible to ifitm3 restriction using a knockout mouse model Everitt A. R., Clare S., McDonald J. U., Kane L., Harcourt K., Ahras M., Lall A., Hale C., Rodgers A., Young D. B., Haque A., Billker O., Tregoning J. S., Dougan G., Kellam P. Plos one, 2013 8 (11): e80723.

The mice used by Plessy et al. were younger than used here and their tissue was collected by laser capture microdissection which could result in incomplete sampling of the whole epithelium.

Greater running distance in the 2 - to 3 - month - old mice may partially explain these data, but the solo - housed wild - type mice used to test solo - versus group - housing (Fig. 5) ran similar distances as the young mice, yet did not show any increase in brain progranulin levels.

Using a surgical technique, the researchers introduced an experimental demyelinating injury in the spinal cord of an old mouse, creating small areas of myelin loss, and then exposed those areas to cells found the blood of a young mouse.

To compliment these behavioral outputs, we additionally performed Serial Two - Photon whole brain imaging and analysis of the distribution, size and density of Aβ - plaques in young and aged AD mice using the TissueCyte ® imaging platform.

We used extracellular field potential recordings to study BST, short - term plasticity (PTP, post-tetanic potentiation; PPF, paired - pulse facilitation) and long - term potentiation (LTP) at the Schaffer collateral - CA1 pyramidal cell synapses in young and old rTg4510 (2 - 3 and 6 - 7 month old) and old APP / PS1 mice (8 - 10 month old).

We here studied, in intact young and aged adult mice, drinking - water (1μM) estradiol effects on both retention and organizational components of hippocampus - dependent memory, using a radial - maze task of everyday - like memory.

The mice used in all these the studies were treated with memantine from a very young age, and we don't know what would happen if the mice received it only after they got sick - which is how most human patients are treated.

We explored how aging affects transcriptional dynamics using single - cell RNA sequencing of unstimulated and stimulated naïve and effector memory CD4 (+) T cells from young and old mice from two divergent species.

Scientists were able to identify the influence caused by factors unique to the blood of young mice, which could ultimately be used as treatments for age - related neurodegenerative disorders.

(G and H) Muscle fibers were automatically identified on H&E - stained sections of quadriceps femoris muscle of the 16 - month (G; young control, n = 786 muscle fibers from 5 mice; vehicle, n = 534 muscle fibers from 6 mice; rapamycin, n = 600 muscle fibers from 8 mice) and 25 - month (H; young control, n = 330 muscle fibers from 6 mice; vehicle, n = 741 muscle fibers from 4 mice; rapamycin, n = 1,371 muscle fibers from 5 mice) cohorts using image segmentation and analysis software.

«The use of antibiotics in young children might lead to a higher risk of obesity, and two new studies, one on mice and one on humans, conclude that changes of the intestinal bacteria caused by antibiotics could be responsible.

These US history for children color pages make great mouse practice activities for younger children but can also be used with older children beginning to learn how to read.

These US history figures coloring pages make great mouse practice activities for younger children but can also be used with older children beginning to learn how to read.

These Religious Jewish Passover coloring pages make great mouse practice activities for younger children but can also be used with older children beginning to learn how to read.

These Black History coloring pages make great mouse practice activities for younger children but can also be used with older children beginning to learn how to read.

These Revolutionary War Coloring Sheets make great mouse practice activities for younger children but can also be used with older children beginning to learn how to read.

These Revolutionary War coloring pages make great mouse practice activities for younger children but can also be used with older children beginning to learn how to read.

These Religious Christian Easter coloring pages make great mouse practice activities for younger children but can also be used with older children beginning to learn how to read.

These Hanukkah coloring pages make great mouse practice activities for younger children but can also be used with older children beginning to learn how to read.

These US History coloring pages make great mouse practice activities for younger children but can also be used with older children beginning to learn how to read.

These Groundhogs Day coloring pages make great mouse practice activities for younger children but can also be used with older children beginning to learn how to read.

These St. Patrick's Day coloring pages make great mouse practice activiWindsocks for younger children but can also be used with older children beginning to learn how to read.

These Valentine's Day coloring pages make great mouse practice activities for younger children but can also be used with older children beginning to learn how to read.

These winter coloring pages make great mouse practice activities for younger children but can also be used with older children beginning to learn how to read.

These Arbor Day coloring pages make great mouse practice activities for younger children but can also be used with older children beginning to learn how to read.

These Christmas reading games make great mouse practice activities for younger children but can also be used with older children beginning to learn how to read.

These Delaware coloring pages make great mouse practice activities for younger children but can also be used with older children beginning to learn how to read.

These Rhode Island coloring pages make great mouse practice activities for younger children but can also be used with older children beginning to learn how to read.

These President Chester Arthur coloring pages make great mouse practice activities for younger children but can also be used with older children beginning to learn how to read.

These President Bill Clinton coloring pages make great mouse practice activities for younger children but can also be used with older children beginning to learn how to read.

These President Andrew Jackson coloring pages make great mouse practice activities for younger children but can also be used with older children beginning to learn how to read.

These Kansas coloring pages make great mouse practice activities for younger children but can also be used with older children beginning to learn how to read.

These President Woodrow Wilson coloring pages make great mouse practice activities for younger children but can also be used with older children beginning to learn how to read.

These Colorado coloring pages make great mouse practice activities for younger children but can also be used with older children beginning to learn how to read.