Sentences with phrase «using zebrafish»

The afternoon session began with from Zurich student Ishani Banik (SWISS2) who presented her ongoing work using zebrafish melanoma models to perform in vivo screening of functional novel oncogenic driver mutations.

One postdoc in Peterson's lab, for example, is using zebrafish to study opioid addiction, trying to identify genes that heighten drug - seeking behavior and thus could be useful targets for helping human addicts.

Using a zebrafish model of DFNB63, we show that the auditory and vestibular phenotypes are due to a lack of mechanotransduction (MET) in Tomt - deficient hair cells.

UT Health SA Newsroom: Surprising finding using zebrafish model explains how recurring cancer may resist treatment

The range of studies using zebrafish is expanding and so it is anticipated that fish will be adopted more and more by researchers in other fields.

The findings, using zebrafish, may have implications for future treatments for the two conditions.

Using a zebrafish embryo xenograft model we also demonstrated that anti-CD90 monoclonal antibodies decreased the viability and metastatic potential of insulinoma cells, suggesting that anti-CD90 monoclonals form a potential novel adjutant therapeutic modality.

Before coming to Columbia she worked as a technician in Leonard Zon's lab at Harvard Medical School using zebrafish as a model for investigating the molecular mechanisms of hematopoietic stem cell differentiation and self renewal.

13:55 - 14:15 Roger Olsson, Lund University, Dept. of Experimental Medical Science Using zebrafish larvae in phenotypic CNS drug discovery and toxicology evaluation

In The Bateson Centre we are identifying genes involved in arteriogenesis using zebrafish embryos.

The researchers are using the zebrafish to study how heart tissue regenerates because the fish have what they called an «amazing capacity» to regenerate the form and function of almost any of their body parts.

He will be working under the direction of Drs. Robert D'Amato and Mehrdad Khajavi, using zebrafish to study angiogenesis.

Using zebrafish as a model system, the researchers exposed the fish embryos to seven different types of TAML activators.

«We are also exploring the possibility of using zebrafish to identify potential drugs that could alleviate pathologies caused by loss of Jagged function,» adds Dong.

This approach opens new avenues for research into memory using zebrafish as model organism,» concludes Dr. Okamoto.

According to Monk and Ackerman, possible future work includes using the zebrafish model system as a drug - screening tool to search for small molecules that may flip that switch.

Using zebrafish, they developed the first animal model for the oligoneural subtype of CNS - PNET.

Yin is using zebrafish to study the regeneration of heart tissue because of the amazing capacity of these common aquarium fish to regenerate the form and function of almost any body part, including heart, bone, skin and blood vessels, regardless of their age.

In the study, the researchers used zebrafish lines that had been selected to be bolder by breeding fish that stayed still for a maximum of 50 seconds after being introduced into new surroundings, while shy fish — those that stayed still for more than 3 minutes when dropped into a new area — were bred to create a shy line.

His lab is continuing to use the zebrafish as a model organism, but Junker also sees great potential in applying the technique to human organoids.

We will continue to use the zebrafish to develop transgenic models.

Dr. Lyons and his team used zebrafish to study the formation of myelin sheaths by oligodendrocytes because this laboratory animal is transparent at early stages of its development, which allows investigators to directly observe cells within the organism.

Tobin also uses zebrafish to study bacteria closely related to those that cause tuberculosis, and findings from this model have been applied to understanding human disease.

The researchers will use their zebrafish model system to search for new therapeutics that could block drug - seeking behavior.

They are aiming to reduce the number of mice used by at least 90 per cent and ultimately use zebrafish to completely replace the use of mice.

«We use zebrafish to study Alagille syndrome because these vertebrates allow us to use experimental approaches that aren't possible with other disease models,» says Duc Dong, Ph.D., assistant professor in the Human Genetics Program at SBP and senior author of the paper.

«Our research used zebrafish to focus on one aspect of this system — how the enterocyte cells inside our intestines respond to a high - fat meal.»

Rieger used zebrafish larvae to model peripheral neuropathy because the embryos develop rapidly and because the larval fish are translucent, making them ideal for studying the progression of nerve degeneration in live animals.

Currently there are at least 600 laboratories around the world that use zebrafish.

We use the zebrafish model to study β - cell development due to the small size and optical transparency of its embryos / larvae, as well as the ease of the genetic and chemical - genetic manipulations, including the ability to conduct large - scale small molecule screens.

Leprosy hijacks our immune system, turning an important repair mechanism into one that causes potentially irreparable damage to our nerve cells, according to new research that uses zebrafish to study the disease.

We use the zebrafish retina as our main model.

At the Bateson Centre at the University of Sheffield, biologists and hospital doctors have teamed up to use zebrafish embryos to learn more about human diseases.

This RegMedNet Podcast talks to Sandra Rieger (MDI Biological Laboratory; Bar Harbor, ME, USA) about how the Rieger lab uses zebrafish as a model to study wound healing mechanisms and nerve regeneration in peripheral neuropathy.

My laboratory uses the zebrafish to elucidate the genetic circuitry that controls regeneration of two organ systems in response to injury: the adult heart and the caudal fin appendage.

We use the zebrafish model to identify genes and mechanisms that regulate normal heart development, function and regeneration, and that can contribute to cardiac diseases in humans.

Whitehead Member Hazel Sive, who collaborated with Bartel and his lab members on the Cell paper, uses zebrafish to study brain development and genetic mutations linked to autism.

His group uses the zebrafish (Danio rerio) as a model system to study various processes.

Not exact matches

Baier's experiments used adult fish, whereas most zebrafish screens use larvae.

Baier plans to use larval stages but he admits it is not clear yet whether the larval zebrafish will react in the same way as the adult mutants.

In a study appearing in the journal Integrative Biology, the researchers used this technology to identify materials that can efficiently deliver RNA to zebrafish and also to rodents.

Zebrafish are commonly used to model human diseases, in part because their larvae are transparent, making it easy to see the effects of genetic mutations or drugs.

In the study, Burdine and two graduate students Jose Pelliccia and Granton Jindal used CRISPR / Cas9 gene editing to remove Vg1, known as Gdf3 in zebrafish.

Last year, researchers used calcium ions to record the neurons firing in a zebrafish embryo.

Already, researchers have used CRISPR / Cas9 to edit genes in human cells grown in lab dishes, monkeys (SN: 3/8/14, p. 7), dogs (SN: 11/28/15, p. 16), mice and pigs (SN: 11/14/15, p. 6), yeast, fruit flies, the worm Caenorhabditis elegans, zebrafish, tobacco and rice.

Using embryos of zebrafish, which was selected for its rapid development and optical transparency, they could show that the mechanical properties of the tissue change along the body axis, facilitating the extension of the body at its posterior end.

Zebrafish larvae a few days old are frequently used in toxicology tests — e.g. to study the behavioural effects of drugs — in order to avoid experiments in mammals.

Different types of studies use different stand - ins: Flies for genetics; zebrafish for early development; rats and mice and monkeys for cancer, neuroscience and more.

Furgeson and his colleagues said that zebrafish could be used to identify «nanomaterial characteristics that afford minimal or no toxicity and guide more rational designs of materials on the nanoscale.»

«Zebrafish could have a unique niche [in cancer treatment],» says Leonard Zon of Harvard Medical School in Boston, who has used the fish for more than a decade to study how cancer develops.