Sentences with phrase «using zebrafish model»

Using a zebrafish model of DFNB63, we show that the auditory and vestibular phenotypes are due to a lack of mechanotransduction (MET) in Tomt - deficient hair cells.

UT Health SA Newsroom: Surprising finding using zebrafish model explains how recurring cancer may resist treatment

According to Monk and Ackerman, possible future work includes using the zebrafish model system as a drug - screening tool to search for small molecules that may flip that switch.

The researchers will use their zebrafish model system to search for new therapeutics that could block drug - seeking behavior.

We use the zebrafish model to study β - cell development due to the small size and optical transparency of its embryos / larvae, as well as the ease of the genetic and chemical - genetic manipulations, including the ability to conduct large - scale small molecule screens.

We use the zebrafish model to identify genes and mechanisms that regulate normal heart development, function and regeneration, and that can contribute to cardiac diseases in humans.

Not exact matches

Zebrafish are commonly used to model human diseases, in part because their larvae are transparent, making it easy to see the effects of genetic mutations or drugs.

Research in the laboratory of Rebecca Wingert, the Gallagher Family Associate Professor of Adult Stem Cell Research in the Department of Biological Sciences at the University of Notre Dame, has confirmed the key role of a certain small molecule in the development of kidney structures in zebrafish, a widely used model for human kidneys.

«Using models such as zebrafish and neonatal mice that regenerate their hearts naturally, we can begin to identify important molecules that enhance heart repair,» said Ellen Lien, PhD, of The Saban Research Institute of Children's Hospital Los Angeles.

For this reason, the zebrafish is now used as a model organism by scientists around the globe.

His lab is continuing to use the zebrafish as a model organism, but Junker also sees great potential in applying the technique to human organoids.

We will continue to use the zebrafish to develop transgenic models.

Using zebrafish, they developed the first animal model for the oligoneural subtype of CNS - PNET.

Tobin also uses zebrafish to study bacteria closely related to those that cause tuberculosis, and findings from this model have been applied to understanding human disease.

We have been using cell culture models and zebrafish as an assay to determine the effects of BMP on signaling, but we also want to be able to understand what the effect of the mutation is in the tissue and organ systems.

The study, published Feb. 16 in PLOS Biology, made use of a mutant zebrafish strain that models human Hirschsprung disease, which is caused by loss of the gut neurons that coordinate gut contractions.

The next steps for the research group are to use what they have learned from this zebrafish model of gut inflammation to design better probiotics to treat intestinal inflammation.

But overall, the resulting toxicity of the wastewater due to its silver content was negligible to zebrafish embryos — a model animal used in toxicity studies.

Bossé explained that the zebrafish model is scalable and could be used to rapidly screen through thousands of compounds.

Using genetic models in a variety of organisms — yeast, nematodes, fruit flies, zebrafish — PLab aims to identify candidate treatment compounds for each disease, which can then be refined and taken to the clinic with partner companies.

The zebrafish is used as a model organism for research into the embryonic development of vertebrates.

«Epilepsy drug discovered in fish model shows promise in small pediatric clinical trial: Research suggests zebrafish models may be efficient resource for identifying drugs for clinical use.»

This approach opens new avenues for research into memory using zebrafish as model organism,» concludes Dr. Okamoto.

«We use zebrafish to study Alagille syndrome because these vertebrates allow us to use experimental approaches that aren't possible with other disease models,» says Duc Dong, Ph.D., assistant professor in the Human Genetics Program at SBP and senior author of the paper.

Researchers have pursued alternative therapies for TB using a variety of animal models, including the zebrafish found in many pet stores and household aquariums.

Using zebrafish as a model system, the researchers exposed the fish embryos to seven different types of TAML activators.

Zebrafish (pictured above) are often used as a model for studying vertebrate development.

«We tested a drug currently used for cancer treatment (vorinostat (Zolinza)-RRB- and found that it reduced average daily seizures in zebrafish and mouse models by 60 per cent,» says Kurrasch.

Tobin, who helped to develop the zebrafish as a model of TB, decided to use the system to study the blood vessels associated with granulomas.

By screening commercially available drugs currently being used for other diseases, researchers found vorinostat to be an effective anti-seizure drug in zebrafish and mouse models.

In addition, the significant number (> 1000) novel models that came from RNA - Seq that were absent from the zebrafish cDNAs suggests that the deep sequencing offered by RNA - Seq can be used to expand the gene annotation of even well - studied model organisms.

Zebrafish can be used as a model to understand what biological effects result from these genetic mutations.

The objective is to support innovative projects dedicated to the development and the study of rare disease models using small animals (mouse model excepted) such as zebrafish, drosophila, nematode, rat and rabbit.

He has made fundamental contributions to our understanding of vertebrate developmental biology and microRNA - based gene regulation using the model organism zebrafish.

Rieger used zebrafish larvae to model peripheral neuropathy because the embryos develop rapidly and because the larval fish are translucent, making them ideal for studying the progression of nerve degeneration in live animals.

CELPHEDIA WP1 workgroup gathers experts using CRISPR / Cas9 system in various animal models including mouse, rat, zebrafish and drosophila.

At the Erasmus Medical Center in Rotterdam, the Netherlands, researchers have investigated this movement disorder using a PARK15 (an atypical early - onset parkinsonism) zebrafish model and DanioVision.

Zebrafish have only been used as a model organism by a lot of labs in the last 15 years or so.

The main focus is to understand how cell biology drives morphogenesis using vertebrate eye formation as a model and zebrafish as main experimental organism.

In order to test whether isradipine, minocycline, and rasagiline could protect or restore locomotor functioning after treatment with 6 - OHDA (a well - known model for Parkinson's), the zebrafish larvae were tested using DanioVision.

We use the zebrafish retina as our main model.

Before coming to Columbia she worked as a technician in Leonard Zon's lab at Harvard Medical School using zebrafish as a model for investigating the molecular mechanisms of hematopoietic stem cell differentiation and self renewal.

In particular we are interested to unravel the mechanisms that ensure the maintenance of the apical membrane when exposed to physical stress, e. g. during morphogenesis of epithelial tissues, or when exposed to light stress in photoreceptor cells, using Drosophila and zebrafish as model organisms.

Using a zebrafish embryo xenograft model we also demonstrated that anti-CD90 monoclonal antibodies decreased the viability and metastatic potential of insulinoma cells, suggesting that anti-CD90 monoclonals form a potential novel adjutant therapeutic modality.

This RegMedNet Podcast talks to Sandra Rieger (MDI Biological Laboratory; Bar Harbor, ME, USA) about how the Rieger lab uses zebrafish as a model to study wound healing mechanisms and nerve regeneration in peripheral neuropathy.

To do that we will activate the pathway in adults of this zebrafish model using gene manipulation techniques, then test the health of eye cells.

Enriched by the rapid evolution of these technologies, TEFOR - TACGene has developed a solid expertise in the design, production and use of TALE - N and CRISPR / Cas9 systems, both for its own research projects in cultured cells and in collaboration, in many model organisms, including the rat, zebrafish, Drosophila, and Xenopus as part of the National Infrastructure in Biology and Health TEFOR supported by Investissement d'Avenir programme (2012 - 2019).

Instead of focusing on marine animals, they use animal models such as freshwater zebrafish, salamanders, fruit flies and nematode worms that share many of their genes with humans.

On the other hand, the present research work shows a confirmatory evidence of the potential of kahweol to inhibit in vivo angiogenesis, by using another completely independent model system, namely, that of genetically modified zebrafish.

For example, the zebrafish, a common aquarium specimen, possesses the remarkable ability to rapidly replace damaged and lost body parts including limbs, heart, and nervous system, making it an ideal model for defining the genetic mechanisms of regeneration and healing and for identifying drug candidates for use in regenerative medicine.