One hypothesis we are exploring is that in
utero HIV - 1 exposure alters the TCR repertoire in infants and leaved a durable imprint on the developing immune system.
One avenue of our translational research aims to determine the impact of in
utero HIV - 1 exposure on infant immunity to vaccinations and co-infections by dissecting the infant immune repertoire present at birth in the context of maternal HIV - 1 infection and how the infant T cell repertoire changes following early life exposures compared to infants born to the HIV - 1 uninfected women of similar socio - economic status.
Not exact matches
Nearly 40 % involved
HIV / AIDS, followed by, in descending order: developmental biology; eye development and disease; other infectious diseases like hepatitis C; miscellaneous; and in
utero diseases, toxic exposures, and congenital conditions.
What component of this increased risk is due to being born into an
HIV - affected household, and how much is due to immunologic modeling in
utero is the subject of continued research in the LVIP lab.