Sentences with phrase «vaccine candidates use»
Other Ebola vaccine candidates use vector viruses to ferry a single Ebola protein, a surface antigen, to prime the immune system.
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Some newer vaccine candidates use harmless viruses such as modified adenoviruses to deliver genes that encode immunizing viral proteins.
Wang and collaborators designed a vaccine candidate using an HIV protein fragment linked to a sugar group.
«Vaccine candidate using genetically engineered malaria parasite developed.»
Not exact matches
«In addition, this platform can be used to develop safe vaccine candidates for other flaviviruses such as Zika virus, where pregnant women are the target group for vaccination.»
Attempts at using live dengue viruses to develop a dengue fever vaccine have often led to an imbalance in immunity to the four dengue serotypes — for instance, one recent candidate had lower efficacy against serotype 2.
By contrast, the new Zika candidate vaccine uses tiny strands of RNA that hold the genetic codes for making viral proteins.
The new candidate vaccine is the first to show such potent and long - lasting protection without the use of a live virus.
While no dengue vaccine has yet been approved for general use, several candidates are in clinical development.
That includes tracking the myriad flu strains circulating globally each year in animals and using the data to help develop candidate vaccine viruses.
The Pilot Bioproduction Facility headed by Dr. Kenneth H. Eckels, produced small batches of vaccine candidates that were used for the preclinical studies and is currently manufacturing a vaccine lot for use in initial human clinical studies.
Our team proposes using the strains containing all the identified evolutionary markers as vaccine candidates for upcoming influenza seasons,» Kainov continues.
Candidate vaccines against Ebola or malaria — one of which recently received an important stamp of approval in Europe — should definitely be used if they are safe and effective, he says, but they could lead to more virulent pathogens.
The researchers theorize that vaccinating camels could reduce the risk of MERS - CoV transmission to people and other camels; NIAID and others are supporting research to develop candidate vaccines for potential use in people and camels.
Finally, Kurtis and colleagues used the antibody to develop a vaccine candidate that they gave to mice infected with a particularly lethal form of malaria.
«Six years ago we began using these samples to identify novel vaccine candidates and now it's coming full circle.
For influenza we offer the ferret model, the «gold standard» for infections with human influenza viruses, which will be used to assess the efficacy of vaccine candidates.
These assays can be used to address the qualitative and quantitative properties of vaccine candidates by analysing (i) the vaccine candidate itself and (ii) antigen - specific immune responses in the serum of patients or immunised animals.
The integrated production platform aims to produce and purify these proteins using a combination of engineered microbial cell factories and flexible approaches for purification to accommodate different vaccines and future candidates.
The objective of the current proposal is to fully characterize an additional vaccine candidate, Clone 10 using the infrastructure and expertise of the Center for International Health Research at Rhode Island Hospital / Brown University and the University of Rhode Island.
One potential use of the vaccine candidate Stamatatos is developing would be to combine it with this or other vaccine candidates, adding to the effect of each.
The availability of a new and improved P. cynomolgi reference genome sequence will enable in - depth studies of this widely used model parasite, including investigations into dormant stages and the selection of new drug targets and vaccine candidates.
We discovered PfSEA - 1 using our whole proteome differential screening method in a search for new vaccine candidates for pediatric falciparum malaria.
In parallel, scientists with the P5 have been developing, analyzing and selecting protein components of the vaccine candidates for use in planned studies.
Research Trials The HVTN also plans to test other HIV vaccine regimens in Southern Africa in a parallel research track using multiple vaccine candidates.
«This isn't the first time that one of the ebolavirus candidate vaccines has been used to try to prevent infection following accidental exposure.
A report of the complete genome sequence of Neisseria meningitidis — the bacteria responsible for meningitis and septicemia — is actually accompanied by a report describing how scientists used the data to find vaccine candidates for groups B N. meningitidis.
Here we report the use of a liposomal vaccine for the generation of a monoclonal antibody with particular characteristics that makes it a valuable tool for fundamental studies as well as a candidate antibody for diagnostic and therapeutic applications.
Picking vaccine candidates from the entire repertoire of genes for an organism «will probably be the only approach used to find vaccines in the future, because the technique is so powerful and so fast,» says Rappuoli.
2015 — Began a new Ebola vaccine study in Abuja, Nigeria, using a monovalent chimpanzee adenovirus Type 3 (ChAd3) candidate developed at the NIAID and being developed by GlaxoSmithKline (GSK), the study sponsor.
Although the efficacy in the Thai study was not high enough to warrant the vaccine's use as a public health tool, the results are helping scientists develop more effective HIV vaccine candidates.
In 2010, we formally demonstrated ADE by developing a mouse mode of ADE - mediated disease, and we began to dissect the contribution of humoral vs. cellular immune components in dengue vaccine - mediated protection using model vaccine candidates as tools to probe the mechanisms by which the vaccine - induced immune responses in mice contribute to protection vs. ADE.
Preclinical studies of vaccine candidates have typically shown post-infection virologic control, but protection against acquisition of infection has previously only been reported using less rigorous viral challenges.
Set of basic assays to address a vaccine candidate antigens size, purity, quantity assembly status (multimers and / or aggregates), and integrity using analytical PAGE, SEC, FPLC / HPLC methods.
TBVAC2020 uses standardised, head - to - head models for the screening of promising vaccine candidates in independent laboratories.
Among other things, it features articles on new developments in HIV cure research, recent studies that show promise but also possible pitfalls of using adenovirus vectors in HIV vaccine candidates, and the funding crisis at the Global Fund to Fight AIDS, Tuberculosis and Malaria.
The Delta VP30 technology has been approved by the National Institutes of Health for use under Biosafety Level 2 conditions and has been utilized safely for a decade to study the basic biology of the virus, identify potential antiviral compound candidates, and make the whole - virus vaccine.
To compile a more comprehensive library of recombinant proteins representing the repertoire of P. falciparum merozoite extracellular proteins for systematic vaccine and functional studies, genome - wide expression profiling was used to identify additional candidates.
IAVI launched the Neutralizing Antibody Consortium (NAC) in 2002 to study the molecular structure and biochemistry of known broadly neutralizing antibodies and to use this information to design (reverse engineer) potentially powerful AIDS vaccine candidates.
In January 2006, VaxGen granted to GSID a worldwide license to research, develop, manufacture, register, use, market, import, offer for sale, and sell its HIV vaccine candidates, including the AIDSVAX B / E vaccine.
VXGN has other potentially valuable assets, including a «a state - of - the - art biopharmaceutical manufacturing facility with a 1,000 - liter bioreactor that can be used to make cell culture or microbial biologic products» and rights to specified percentages of future net sales relating to its anthrax vaccine product candidate and related technology.
VXGN has other potentially valuable assets, including a «state - of - the - art biopharmaceutical manufacturing facility with a 1,000 - liter bioreactor that can be used to make cell culture or microbial biologic products» and rights to specified percentages of future net sales relating to its anthrax vaccine product candidate and related technology.
Dr. Ben Stading, a veterinarian, public health specialist and PhD candidate at the University of Wisconsin — Madison, is investigating the use of topical delivery of vaccines in a gel or paste that bats will ingest when grooming themselves.